ISSN:
1573-6830
Keywords:
interleukin-1β
;
interleukin-1 receptor antagonist
;
immobilization stress
;
reverse transcription–polymerase chain reaction
;
brain
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract 1. Interleukin-1 receptor antagonist (IL-1Ra), as well as the interleukin-1β (IL-1β) gene response to immobilization stress (IMS), was examined in the rat brain. The reverse transcription–polymerase chain reaction was employed to determine mRNA levels. 2. IL-1β and IL-1Ra mRNA levels peaked at approximately 0.5 and 2–4 hr, respectively. The maximum mRNA levels of IL-1β were 15-fold higher than pre-IMS levels, whereas those of IL-1Ra were 250-fold higher in the hypothalamus. 3. After the biosynthesis of IL-1β has peaked, IL-1Ra may contribute to attenuation of the IL-1 activity which has been enhanced by IMS.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026319107528
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