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  • 1
    Electronic Resource
    Electronic Resource
    The relationship between the QT interval and plasma amiodarone concentration in patients on long-term therapy (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 115-118 
    Details
    ISSN: 1432-1041
    Keywords: amiodarone ; antiarrhythmic drug ; QT interval ; blood level monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied 27 patients on long-term treatment (6–60 months) with amiodarone (dose range 350 mg per week to 2800 mg per week) to ascertain whether the corrected QT interval could predict plasma amiodarone or plasma desethylamiodarone concentration. The patients were assessed on three or four occasions one month apart. There were positive correlations for Δ% QTc and plasma amiodarone and Δ% QTc and plasma desethylamiodarone. There was approximately a four-fold variation for Δ% QTc and plasma amiodarone. This variation was not accounted for by between-occasion variation in the QTc interval, as the coefficient of variation was 2.1%. In six of the patients Δ% QTc either decreased or did not change. Δ% QTc is not a reliable predictor of plasma amiodarone concentration in the individual patient over time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544553
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    INCREASE IN HAEMATOCRIT IN BORDERLINE HYPERTENSIVE MEN (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 21 (1994), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Haematologic parameters were measured in untreated borderline hypertensive (BHT) men, and weight and age matched with normotensive men to determine whether previously described increased haematocrit (Hct) in established hypertension is evident in borderline hypertension.2. Haematocrit was significantly increased in BHT men (mean 0.46, s.d. 0.032) compared with normotensive men (mean 0.43, s.d. 0.014) and correlated significantly with mean arterial pressure in this group (r = 0.67, P= 0.036) independent of weight.3. The correlation of blood pressure with Hct in BHT men supports the concept that increased Hct may contribute to increased blood viscosity and thus to raised arterial pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1994.tb02533.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    TRANSMEMBRANEIN VITRO AND IN VIVO SODIUM-LITHIUM COUNTERTRANSPORT IN NEW ZEALAND MAORI (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 20 (1993), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Erythrocytic sodium-lithium (Na-Li) countertransport (CT) was measured in normotensive Maori and non-Maori by in vitro and in vivo methods to determine its relationship to erythrocytic hypernatraemia previously identified in Maori.2. In vivo and in vitro CT rates were correlated within race and were similar between races. Countertransport rate was correlated with erythrocytic sodium concentration only in Maori.3. The findings suggest the possibility of a genetically determined alteration in CT stoichiometry in Maori.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1993.tb01685.x
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    Paper (German National Licenses)
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