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  • 1
    Electronic Resource
    Electronic Resource
    AMINO ACID UPTAKE AND INCORPORATION INTO MACROMOLECULES OF PERIPHERAL NERVES (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The uptake and incorporation of various isotopically labelled amino acids by the amphibian peripheral nerve were analysed within 5 to 24 hr after intraperitoneal injection. Amino acid was accumulated rapidly by nerve and some was incorporated into macromolecules. Nerve separated by transection from its cell bodies showed similar accumulation and incorporation. The uptake by nerve was found to be as high as that for brain and liver. A substantial amount of the isotope was recovered in the protein fraction of peripheral nerve. A lesser, but significant, amount was isolated with aminoacyl-tRNA. The contribution of specific amino acids to the nucleic acid and lipid fractions was also assessed. Finally, the significance of our findings in the understanding of nerve metabolism is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb05981.x
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  • 2
    Electronic Resource
    Electronic Resource
    ‘Merit’, ‘Preferential’or ‘Diversity-Based’Selection: Effect of Information Frame and Informant Gender on the Public's Views on Preferential Treatment in Selection (1996)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of selection and assessment 4 (1996), S. 0 
    Details
    ISSN: 1468-2389
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: The study examined (1) the public's reactions to the philosophical justifications for merit vs. preferential selection, and (2) the effect of information frame (i.e. ‘merit’, ‘preferential’and ‘diversity’frames) and informant gender on people's views on preferential selection. Results show that in general the public supported merit selection and opposed the preferential practice and that their reactions to the justifications for a selection practice determined the level of support for (or opposition to) that practice. In addition, people's support for merit selection was weakened under the preferential-frame-female-informant condition; their opposition to preferential selection was also reduced when a male informant advocated the advantages of the preferential practice by using the term diversity-based selection instead of preferential selection. Results were discussed in the context of the social influence literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-2389.1996.tb00042.x
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  • 3
    Electronic Resource
    Electronic Resource
    Severe anaphylactoid reaction to hydroxyethyl starch (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 45 (1990), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case is presented of a severe anaphylactoid reaction to hydroxyethyl starch solution that occurred peri-operatively and required extended intensive management of the resultant bronchospasm and hypotension. Subsequent intradermal injection of hetastarch produced a delayed positive response, suggestive of a complement-mediated mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1990.tb14883.x
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  • 4
    Electronic Resource
    Electronic Resource
    Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit (1999)
    Oxford : Blackwell Science Ltd
    Anaesthesia 54 (1999), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dexmedetomidine, a highly selective and potent α2-adrenergic agonist, has a potentially useful role as a sedative agent in patients requiring intensive care. As part of a larger European multicentre trial, a total of 119 postoperative cardiac and general surgical patients requiring ventilation and sedation in an intensive care unit were enrolled in four centres in the United Kingdom. One hundred and five patients were randomly allocated to receive either dexmedetomidine or placebo with rescue sedation and analgesia provided by midazolam and morphine, respectively. Compared with the control group, intubated patients receiving dexmedetomidine required 80% less midazolam [mean 4.9 (5.8) μg.kg−1.h−1 vs. 23.7 (27.5) μg.kg−1.h−1, p 〈 0.0001], and 50% less morphine [11.2 (13.4) μg.kg−1.h−1 vs. 21.5 (19.4) μg.kg−1.h−1,p = 0.0006]. Cardiovascular effects and adverse events could be predicted from the known properties of alpha-2 agonists. In conclusion, dexmedetomidine is a useful agent for the provision of postoperative analgesia and sedation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.1999.01114.x
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  • 5
    Electronic Resource
    Electronic Resource
    New Procedures for the Preparation of Complexes of Ribosomes with Polyuridylic Acid* (1967)
    s.l. : American Chemical Society
    Biochemistry 6 (1967), S. 2678-2685 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00861a006
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  • 6
    Electronic Resource
    Electronic Resource
    Messenger RNA: An Evaluation (1966)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 35 (1966), S. 195-230 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bi.35.070166.001211
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  • 7
    Electronic Resource
    Electronic Resource
    Butterfly Ecology (1975)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Ecology, Evolution, and Systematics 6 (1975), S. 365-395 
    Details
    ISSN: 0066-4162
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.es.06.110175.002053
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  • 8
    Electronic Resource
    Electronic Resource
    The diffusion of small ions through phospholipid bilayers (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 7218-7226 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The passage of the alkali metals Li, Na, K, Rb, and Cs through saturated phosphatidylcholine membranes has been measured using particle induced gamma ray and x-ray emission to observe the ions. Simultaneous measurements of these five cations has not been possible with more traditional methods involving ion specific electrodes or radioactive tracers. To the authors' knowledge this is the first time this technique has been used in lipid bilayer research. The ion leakage was determined for an incubation period of 30 min at several temperatures which spanned the bilayer melting temperature. The dependence of this permeability on temperature, acyl chain length, and ion size is described theoretically in terms of the density fluctuations in the bilayer. A leakage rate which depends on the mass of the ion was observed. This dependence shows that the heavier the ion the faster it diffuses out of the vesicle. The effect of this selectivity is shown to be most pronounced near the melting temperature of the lipid. Moreover, this size dependence suggests that the permeating entity is a hydrated ion, rather than a naked ion or a neutral, bound ion pair.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.452323
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  • 9
    Electronic Resource
    Electronic Resource
    Extended freeze-dried Mycobacterium bovis Bacillus Calmette–Guérin induces the release of interleukin-12 but not tumour necrosis factor-α by alveolar macrophages, both in vitro and in vivo (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Airway hyper-responsiveness (AHR), chronic airway inflammation and predominance of the T helper type-2 (Th2; IL-4, IL-5, IL-13) over the Th1 (IL-2, IFN-γ) immune response are hallmarks of asthma. Alveolar macrophages (AM) are the most numerous cells in the airway lumen, where they represent the first immune cell population encountered by inhaled antigens. AM act as antigen-presenting cells (APC) and they release various soluble mediators and enzymes. AM thus play a prominent role in the modulation of the local immunity in airways. In allergic airways, AM have been implicated in the pathogenesis of inflammation by promoting the Th2 versus the Th1 cytokine patterns.Objectives Infections with attenuated bacteria or challenges with bacterial products may involve AM. Such stimuli have been shown to potentially restore the Th1/Th2 balance in asthmatic airways, but they also induce the release of inflammatory mediators. We investigated the response of AM when stimulated by two preparations of non-proliferating Bacillus Calmette–Guérin (BCG).Methods We evaluated the cytokine production by AM from BP2 and C57BL/6 mice when cultured with heat-killed (HK) and extended freeze-dried (EFD) BCG. We then investigated in vivo the release of soluble factors in the airway lumen of mice after instillation of these BCG preparations. Finally, we studied the profile of cytokine transcripts in the lung of mice pre-treated with BCG and then challenged with ovalbumin (OVA).Results HK BCG induced the production of both TNF-α and IL-12, and did not prevent high levels of Th2 cytokine transcripts. In contrast, EFD BCG induced a response dominated by the production of IL-12, with no later over-expression of Th2 cytokine transcripts.Conclusion Our results show that EFD BCG induce the release of the Th1-promoting cytokine IL-12 by AM, without the deleterious effects of HK BCG. These data suggest that EFD BCG may be considered as a potential novel treatment to restore the Th1/Th2 imbalance in asthma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01612.x
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  • 10
    Electronic Resource
    Electronic Resource
    APPLICANT AGE AND SELECTION INTERVIEW DECISIONS: EFFECT OF INFORMATION EXPOSURE ON AGE DISCRIMINATION IN PERSONNEL SELECTION (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Personnel psychology 42 (1989), S. 0 
    Details
    ISSN: 1744-6570
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Notes: Two research questions pertaining to the applicant age bias effect were addressed in this study: the effect of age-related information exposure on selection decisions and the issue of between-sample generalizability with reference to the age bias effect. Manager and student selectors made selection decisions after viewing one videotape of a simulated selection interview of either an old or a young job applicant. Before viewing the interview tape, half of each subject group was given an item of age-related information and the other half was given neutral information. The results showed that, under the neutral information condition, managers preferred hiring the young applicant for the low-status job, and students favored the old candidate for the high-status position. Under the age-related information condition, managers shifted to favoring the old candidate for the low-status job, and students preferred the young applicant for both the low- and high-status positions. Age discrimination in selection decisions and the lack of external validity of student results in selection research are then discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-6570.1989.tb01554.x
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