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  • 1
    Electronic Resource
    Electronic Resource
    Human serum albumin-benzo[a]pyrene anti-diol epoxide adduct structure elucidation by fluorescence line narrowing spectroscopy (1992)
    s.l. : American Chemical Society
    Chemical research in toxicology 5 (1992), S. 71-76 
    Details
    ISSN: 1520-5010
    Source: ACS Legacy Archives
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/tx00025a012
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  • 2
    Electronic Resource
    Electronic Resource
    A viable alternative to surgical vacuum aspiration: repeated doses of intravaginal misoprostol over 9 hours for medical termination of pregnancies up to eight weeks (2003)
    Oxford, UK : Blackwell Science Ltd
    BJOG 110 (2003), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To study the efficacy of repeated doses of vaginal misoprostol over 9 hours in a day care setting for terminating pregnancies up to eight weeks of gestation.Design An open, single arm prospective study conducted between January 2000 and December 2001.Setting Fertility Control Clinic, National University Hospital, Singapore.Population One hundred and fifty pregnant women with an unwanted pregnancy up to eight weeks of gestation requesting medical abortion.Methods The women were given an initial dose of 800 μg of vaginal misoprostol. A further dose of 400 μg was repeated every 3 hours for a maximum of three doses.Main outcome measures The complete abortion rate defined as successful cases that did not require vacuum aspiration.Results The complete abortion rate was 84.7% and 96.0% at 15 days and 43 days after initial administration of vaginal misoprostol. The mean interval between first dose of misoprostol and the onset of expulsion of products of conception (SD) was 8.1 hours (6.3). The mean and the median percentage changes in the serum β-hCG levels at day 15 as compared with pre-abortion levels were statistically significant (P 〈 0.001) and were a good predictor of the likely outcome of the medical abortion. The mean duration of bleeding (SD) was 11.7 days (4.7) and the mean duration between the onset of procedure and the return of normal menstruation (SD) was 35.5 days (5.7). There was no significant change in haemoglobin concentration. Lower abdominal pain, fever (〉38.0°C) and diarrhoea were the most common side effects.Conclusions This regimen of repeated doses of vaginal misoprostol every 3 hours over a period of 9 hours, in keeping with the plasma level and pharmacokinetic of misoprostol administered vaginally, is an effective method of medical abortion that approaches the efficacy of surgical vacuum aspiration. The regimen would offer a suitable option for women requesting termination of pregnancy up to eight weeks of gestation in countries where mifespristone is and will never be made available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-0528.2003.02225.x
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  • 3
    Electronic Resource
    Electronic Resource
    A comparative study using two dose regimens (200 μg or 400 μg) of vaginal misoprostol for pre-operative cervical dilatation in first trimester nulliparae (1998)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 105 (1998), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine the optimal dosage and dosing interval for the use of misoprostol administered vaginally for pre-operative cervical dilatation.Design Prospective double-blind randomised study.Setting Fertility Control Centre, National University Hospital, Singapore.Methods Women were randomly allocated to either the 200 μg or the 400 μg misoprostol group. Vacuum aspiration was performed at either three or four hours after the insertion of misoprostol tablets. Using Hegar's dilatator, degree of cervical dilatation before operation was measured. Other parameters assessed included the amount of additional dilatation required (if it was 〈 Hegar 8), pre-operative and intra-operative blood loss, and associated side effects.Results For the 200 μg misoprostol group, only seven (23.3%) achieved a dilatation of ≥ 8 mm compared with 29 women (96.7%) in the 400 μg misoprostol group. The odds ratio was 95.3 (95% CI 10.9–830.9) for 400 pg misoprostol for successful pre-operative cervical dilatation of ≥ 8 mm. The mean cervical dilatation for 400 μg and 200 μg misoprostol was 8.2 mm and 6.4 mm, respectively (P 〈 0.001). The use of 400 pg misoprostol with an evacuation interval of three hours appears to be the optimal dosage and evacuation time interval. Increasing the time interval beyond three hours did not confer any additional advantage on the rate of successful cervical dilatation but was instead associated with an increase in side effects such as vaginal bleeding, lower abdominal pain and the appearance of products of conception at the cervical os. However, besides vaginal bleeding, no significant differences in the frequency of these side effects were demonstrated.Conclusion This first report on the comparison of differing dosages and time intervals to determine the optimal dosage treatment schedule shows that the vaginal application of 400 μg misoprostol for at least three hours is optimal for pre-operative cervical dilatation before vacuum aspiration in first trimester nulliparae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1998.tb10126.x
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  • 4
    Electronic Resource
    Electronic Resource
    Vaginal misoprostol for pre-abortion cervical priming: is there an optimal evacuation time interval? (1999)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 106 (1999), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine the optimal evacuation time interval in the use of vaginal misoprostol for cervical priming before first trimester termination of pregnancy.Design Prospective double-blind randomised study.Setting Fertility Control Centre, National University Hospital, Singapore.Methods Sixty healthy nulliparous women requesting legal termination of pregnancy between 6 and 11 weeks of gestation were randomly allocated to either the 400 pg or 600 μg misoprostol group. Vacuum aspiration was performed after three hours in the 400 pg group and at the end of two hours in the women given 600 μg misoprostol. Using Hegar's dilator, degree of cervical dilatation before operation was measured. Other parameters assessed included the amount of additional dilatation required (if 〈 Hegar 8), pre-operative and intra-operative blood loss, and associated side effects.Results For the 600 pg group, only five women (16.7%) achieved a cervical dilatation of 2.8 nun, compared with 28 women (93.3%) in the 400 μg group. Using the 400 μg misoprostol group as a baseline, the odds ratio was 0.014 (95% CI 0.003–0.080) for 600 pg for successful pre-operative cervical dilatation of 2.8 mm. The mean cervical dilatation for 400 and 600 μg misoprostol was 8.1 mm and 6.6 mm, respectively (P 〈 0.001). Despite the shorter evacuation time interval of two hours, the 600 μg dose was associated with an increase in side effects such as vaginal bleeding, abdominal pain and a fever of 〉 38.°C. However, other than abdominal pain, no significant differences in the frequency of these side effects were shown.Conclusion Use of 400 μg misoprostol with a minimal evacuation time interval of three hours still appears the optimal dosage and evacuation time for cervical priming before fiist trimester termination of pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1999.tb08241.x
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  • 5
    Electronic Resource
    Electronic Resource
    Enantiospecificity of Covalent Adduct Formation by Benzo[a]pyrene anti-Diol Epoxide with Human Serum Albumin (1994)
    s.l. : American Chemical Society
    Chemical research in toxicology 7 (1994), S. 829-835 
    Details
    ISSN: 1520-5010
    Source: ACS Legacy Archives
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/tx00042a017
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  • 6
    Electronic Resource
    Electronic Resource
    Characterization of benzo[a]pyrene anti-diol epoxide adducts to human histones (1994)
    s.l. : American Chemical Society
    Chemical research in toxicology 7 (1994), S. 134-138 
    Details
    ISSN: 1520-5010
    Source: ACS Legacy Archives
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/tx00038a004
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  • 7
    Electronic Resource
    Electronic Resource
    Titrimetric determination of xanthates with ICN and BrCN (1974)
    Springer
    Microchimica acta 62 (1974), S. 801-814 
    Details
    ISSN: 1436-5073
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Methyl-, Äthyl,i-Propyl-, Allyl-,n-Butyl-,t-Butyl-,i-Amyl-, Cyklohexyl und Benzylxanthate des Kaliums wurden durch Titration mit Jod- und Bromcyanid in wäßrigem Medium bei pH 5,0–5,4 und in Acetonitril, Äthanol, Äthanol-Tetrachlormethan (1∶1) bzw. in Äthylacetat bestimmt. Diese Titrationen erfolgten visuell bzw. potentiometrisch. Die Xanthate reagieren mit diesen Oxydationsmitteln im Molarverhältnis 2∶1 zu Dixanthogen. Die potentiometrische Titration von Bromcyan mit Xanthaten ist im Gegensatz zu anderen Reduktionsmitteln in wäßrigem Medium möglich auch ohne Anwesenheit von Jodid, das bei visueller Titration in Ermangelung eines spezifischen Indikators zugesetzt werden muß. Die Titrationen sind rasch, einfach, genau und reversibel. Sie eignen sich in wäßriger Phase und in Acetonitril zur Bestimmung von nur 1 mg.
    Notes: Summary Methyl, ethyl,iso-propyl, allyl,n-butyl,t-butyl,iso-amyl, cyclohexyl and benzyl xanthates of potassium have been determined by titrating with iodine and bromine cyanides in aqueous medium at pH 5.0–5.4 and in acetonitrile, ethanol, 1 ∶ 1 ethanol-carbon tetrachloride mixture and ethyl acetate media visually and/or potentiometrically. The xanthates react in the molar ratio 2 ∶ 1 with these oxidants and are oxidised to dixanthogen. The potentiometric titrations of BrCN with xanthates, unlike with other reductants, are possible in aqueous medium even in absence of iodide which has to be added in visual titrations because of a lack of some specific indicator. The titrations are rapid, simple, accurate and reversible and as little as 1 mg can be determined in aqueous or acetonitrile medium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01218299
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  • 8
    Electronic Resource
    Electronic Resource
    Structure, solvatochromism, and solvation of trans-[CoIII(cyclam)(NCS)2](NCS) and the structure of [CoII(Me4cyclam) (NCS)]2[Co(NCS)4]MeOH (1999)
    Springer
    Transition metal chemistry 24 (1999), S. 355-361 
    Details
    ISSN: 1572-901X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The structures of trans-[CoIII(cyclam)(NCS)2](NCS) and of [CoII(Me4cyclam)(NCS)]2[Co(NCS)4]·MeOH have been established by X-ray diffraction methods. The solvatochromic behavior of the trans-[Co(cyclam)(NCS)2]+ cation in several binary aqueous solvent mixtures is reported. Transfer chemical potentials for this complex from H2O into MeOH-H2O mixtures have been established from solubility measurements on its thiocyanate salt. The solvatochromic behavior of this cation is discussed in the context of other solvatochromic inorganic complexes; its transfer chemical potentials are discussed in relation to those of other cobalt(III) complexes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006941200261
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  • 9
    Electronic Resource
    Electronic Resource
    Solubilities and solvation of bis-(2,2′-bipyridyl)- and bis-(1,10-phenanthroline)dicyanoiron(II) in alcohols (1994)
    Springer
    Transition metal chemistry 19 (1994), S. 113-114 
    Details
    ISSN: 1572-901X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Solubilities of bis-(2,2′-bipyridyl)- and bis-(1,10-phenanthroline)dicyanoiron(II) are reported for a range of primary aliphatic alcohols, from MeOH to 1-decanol. The established trends are compared with those for other solutes, and for the title compounds in H2O-alcohol solvent mixtures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00166283
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  • 10
    Electronic Resource
    Electronic Resource
    Absorption coefficients for the 727 nm band of methane at 77 K determined by intracavity laser spectroscopy (1996)
    Springer
    Astrophysics and space science 236 (1996), S. 97-109 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Methane spectral features in the visible to near-IR region are prominent in the spectra of the outer planets but laboratory data for the appropriate methane conditions are required to interpret the observational data. By use of the intracavity laser spectroscopy technique, a moderately high resolution (≥500,000) absorption spectrum of the 727 nm band of methane at 77 K is obtained. The methane absorption bands in the visible to near-IR region are very weak, but intracavity laser spectroscopy provides sufficient sensitivity to perform the measurements and to extract quantitative data for methane at low temperatures. Absorption coefficients are determined and are reported as averages at one Å intervals throughout the region 7127–7420 Å. By integrating over the band, an intensity of 753 cm−1 km−1 am−1 is obtained. The results compare well with previous low resolution measurements on methane at room temperature, with gas phase results calculated using the absorption spectrum of liquid methane, and with absorption coefficients derived from methane features observed in the spectra of the outer planets and Titan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644324
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