ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Exposure to Low Doses of Solar-Simulated Radiation Induces an Increase in the Myeloid Subtype of Blood Dendritic Cells (2004)

Narbutt, J. ; Skibinska, M. ; Lesiak, A. ; [et al.]

Oxford, UK; Malden, USA : Blackwell Science Ltd

Scandinavian journal of immunology 60 (2004), S. 0

add to mindlist on the mindlist

Details

ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Exposure to ultraviolet radiation causes alterations of cutaneous and systemic immunity. The aim of our study was to assess the influence of low doses of solar-simulated radiation (SSR) on the phenotypes of blood dendritic cells (BDC). Healthy volunteers (94) were irradiated with a dose of 1.2 SED (standard erythema dose) of SSR for 2, 10 or 30 consecutive days. Blood samples were taken before the first exposure and 24 h after final exposure. The three main subsets of BDC were distinguished by flow cytometry: BDCA-2+/CD123+/HLA-DR+ (plasmacytoid, PDC) and two myeloid subtypes BDCA-1+/CD11c+/HLA-DR+ (MDC1) and BDCA-3+/CD32–/HLA-DR+ (MDC2). The percentage of total DC was elevated in all groups by the UV exposure and was significantly increased after 2 and 30 days of irradiation (P = 0.006 and P = 0.018, respectively). A particularly distinct increase was observed in the percentage of the MDC1 after 2 and 30 days (P = 0.022 and P 〈 0.0001, respectively). The MDC2 showed an increase after 10 days and a subsequent significant decrease after 30 days of irradiation (P = 0.031). A significant increase in PDC was found after 2 days of irradiation (P = 0.0006). Exposure to SSR induced an increase in the percentage of BDC in healthy human individuals, especially apparent in the MDC1 subtype.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.0300-9475.2004.01489.x

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

New synthetic route to 9α-hydroxy-4-androsten-3,17-dione (1989)

Uszycka-Horawa, T. ; Skibińska, M. ; Jakubowski, W.

Berlin : Wiley-Blackwell

Acta Biotechnologica 9 (1989), S. 447-451

add to mindlist on the mindlist

Details

ISSN: 0138-4988

Keywords: Life Sciences ; Life Sciences (general)

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Process Engineering, Biotechnology, Nutrition Technology

Notes: The new synthesis of 9α-hydroxy-4-androsten-3,17-dione from hydrocortisone is described. The six-step reaction sequence involved degradation of the side chain, dehydration, ketals formation, reduction of the α-epoxide to 9α-hydroxyderivative and ketal groups cleavage. The overall yield is about 12%. Physico-chemical data of two new compounds were determined.

Additional Material: 1 Ill.