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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 19 (1986), S. 2291-2294 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 106 (1984), S. 6155-6161 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 56 (1984), S. 1773-1777 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 12 (1977), S. 451-456 
    ISSN: 1432-1041
    Keywords: Bioavailability ; carbamazepine ; elimination ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The time-courses of plasma carbamazepine concentrations were followed in six apparently healthy adult subjects who, at different times, took single oral drug doses of 200, 400, 500, 600, 700, 800 and 900 mg. There were some suggestions of impaired bioavailability of the drug when given in tablet form. The following values were obtained for various pharmacokinetic parameters:k abs =0.176±0.209 h−1;k=0.0203±0.0055 h−1; T1/2=37.5±13.1 h; VD=0.825±0.1041 · kg−1; Clearance=0.0163±0.0061 l · kg−1. The elimination rate constant showed a statistically significant increase with increasing drug dose. This may help explain the clinical observation that the rate of rise of steady state plasma carbamazepine concentrations tends to decrease with dose increase in patients taking carbamazepine alone.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 23 (1971), S. 221-228 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary No infallible preoperative method exists to predict accurately a patient's tolerance to unilateral carotid artery ligation. It has recently been hypothesized that the magnitude of increase in contralateral carotid artery flow resulting from trial compression of the ipsilateral common carotid artery might be of value in determining the result of permanent ligation. The purpose of this study is to evaluate three factors which might influence the contralateral flow increase: the carotid sinus reflex, the vertebro-basilar artery circulation, and the degree of anastomotic crossover in the anterior part of the circle of Willis. The effects of these three factors were studied in the following situations: (1) Before and after ablation of the ipsilateral carotid sinus in eight dogs (by cutting the ninth and tenth cranial nerves); (2) Before and after ligation of both vertebral arteries in three dogs: (3) Before and after separation of the anterior circle of Willis by clipping an anterior cerebral artery in two monkeys.Results: (1) Carotid sinus denervation had no effect in three dogs, diminished the increase by an average of 25% in three dogs, and enhanced the increase by an average of 50% in two dogs: (2) Bilateral vertebral artery ligation enhanced the increase in all three dogs by an average of 66%; (3) Separation of the anterior circle of Willis caused a diminution of the increase in both monkeys by an average of 66%; (4) There was no relationship between the degree of contralateral flow increase and 1. systemic blood pressure, 2. contralateral flow prior to occlusion, or 3. ipsilateral flow prior to occlusion.Conclusions: (1) In the experimental situation, the carotid sinus reflex is not consistently responsible for the contralateral carotid flow increase; (2) The observations on the vertebral artery occlusion and monkey studies lend support to the concept that if a contiguous vascular bed is removed from access to carotid blood, the flow through the system will decrease, and vice versa. The data are placed into clinical perspective.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 49 (1984), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Casein, casein-starch, casein-sucrose, and casein-glucose mixtures were heated under conditions modeling storage, autoclaving, baking/broiling and charring (37–300°C). Losses in total and chemically available lysine content were measured by fluorodinitrobenzene (FDNB) and dye-binding methods. The lysine and arginine content decreased up to 99%. Changes in amino acid profiles were accompanied by the appearance of at least five new ninhydrin-positive compounds. The relative potencies of the three carbohydrates effecting these changes were different at the four temperatures studied. The available lysine contents of the samples measured by the two independent methods were identical within experimental error. The results show different susceptibilities of casein to heat- induced damage in the presence of different carbohydrates.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 49 (1984), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A lithium acetate-dimethyl sulfoxide ninhydrin reagent was shown to be useful for reaction of amino groups in a series of structurally diverse food proteins and flours of variable lysine content. The proteins were bovine serum albumin, casein, hemoglobin, lactalbumin, lysozyme, soybean protein, soybean trypsin inhibitor, trypsin, and wheat gluten. The flours were barley, high lysine corn, high protein rice, lima bean, nonfat dry milk, rice, soy, and wheat. The ninhydrin-reactive lysine content of these proteins varied from 63-109% of the theoretical values. This variation needs to be taken into account in possible applications of the ninhydrin reaction to food proteins.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 10 (1983), S. 0 
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Mechanical attachments used to improve retention of overdentures have their limitations. With the recent development of the cobalt-samarium magnet an alternative method of achieving increased overdenture retention is offered. The most suitable form of magnet appears to be of a reverse split pole design with a ferromagnetic disc or keeper which will ensure a closed magnetic field. Clinical techniques involve conventional endodontic therapy, and the basic method of overdenture construction can be followed with only minor modification.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 115 (1996), S. 0 
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: This report documents the difficulty breeders have experienced in combining resistance to Cercospora leaf spot (causal agent Cercospora beticola Sacc.) with high yield in sugarbeet (Beta vulgaris L.). Forty commercial hybrids, all recommended for Cercospora-threat areas, were grown in a Cercospora-free and a diseased (inoculated) environment in 1991 and 1992. A 2.9 Mg/ha decrease in root yield associated with each increment increase in susceptibility confirmed that under a severe epiphytotic (1991) Cercospora resistance provided substantial protection. Under less-severe disease conditions (1992) there was no apparent relationship between yield and resistance, suggesting that the benefits of resistance were similar to the yield potential sacrificed to obtain the resistance. In the absence of the disease, root yields increased 2.7 Mg/ha for each increment of increased susceptibility. There was no evidence of association between sucrose concentration and resistance in the Cercospora-free environment. Despite the limited efforts and/or success in developing resistant commercial hybrids, the demonstrated ability of Cercospora to produce fungicide-resistant strains and the possibility that effective fungicides will not be available provide incentives to seek genetic resistance through breeding efforts.
    Type of Medium: Electronic Resource
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