Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Book
    Book
    Physiologie : mit 88 Tabellen ; plus CD-ROM mit Prüfungsfragen und allen Abbildungen (2004)
    München :Urban & Fischer,
    Details
    Title: Physiologie : mit 88 Tabellen ; plus CD-ROM mit Prüfungsfragen und allen Abbildungen
    Contributer: Deetjen, P. , Speckmann, E. J. , Hescheler, J.
    Edition: 4., vollst. überarb. Aufl.
    Publisher: München :Urban & Fischer,
    Year of publication: 2004
    Pages: XII, 888 S. : , 550 farb. Abb., 80 farb. Tab. +
    ISBN: 3-437-41317-1
    Type of Medium: Book
    Language: German
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    ZIB Catalog
    Zuse Institute Berlin get availability status
  • 2
    Electronic Resource
    Electronic Resource
    Actions of pentylenetetrazol (PTZ) on CA3 neurons in hippocampal slices of guinea pigs (1986)
    Springer
    Experimental brain research 64 (1986), S. 94-104 
    Details
    ISSN: 1432-1106
    Keywords: Hippocampal slices ; CA3 neurons ; Pentylenetetrazol ; Paroxysmal hyperpolarizations ; Paroxysmal depolarizations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The actions of the convulsant drug pentylenetetrazol (PTZ) were studied on CA3 neurons of hippocampal slices (300–400 μm thick). In 9 out of 109 neurons, epileptic reactions were elicited during a single application of PTZ. After repeated applications of PTZ, 53 neurons showed periodic paroxysmal activity. They developed according to the following sequence: (i) Paroxysmal hyperpolarizations, (ii) burst activity, and (iii) typical paroxysmal depolarization shifts (PDS). The rate of occurrence was about 8/min. Paroxysmal hyper- and depolarizations appeared synchronously in pairs of neurons. The developmental sequence occurred in reverse during washing. After the onset of paroxysmal activity, bursts and PDS persisted if PTZ concentration in tissue ranged between about 2 and 10 mmol/l. When this range was exceeded in either direction, epileptic activity was abolished at a calcium concentration of 2.75 mmol/l. Decreasing and increasing the calcium concentration shifted the epileptogenic concentration range to lower and higher levels, respectively. It is concluded that repetition of PTZ application alters membrane properties of neurons and thus leads to paroxysmal events triggered by synaptic processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238204
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Melatonin reduces low-Mg2+ epileptiform activity in human temporal slices (1995)
    Springer
    Experimental brain research 107 (1995), S. 321-325 
    Details
    ISSN: 1432-1106
    Keywords: Epilepsy ; Melatonin ; Low Mg2+ ; Epileptiform field potentials ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Scizure susceptibility waxes and wanes in an apparently circadian manner in many epileptic patients. Fluctuations of melatonin concentration with highest levels during the night and lowest levels in the early morning could be involved in this phenomenon. Therefore, the action of melatonin on epileptic activity was tested. The experiments were carried out on human temporal neocortical slices cut from tissue resected for surgical treatment of epilepsy. Autoradiographic studies were performed on parallel slices with 100–120 pmol 2-[125I]iodomelatonin/l in the absence or presence of unlabelled melatonin. High-affinity binding sites of melatonin could be demonstrated in layers II–V of the temporal cortex. The binding was saturable, specific and occurred with low capacity. In electrophysiological studies, epileptiform field potentials were elicited by omission of Mg2+ from the superfusate and recorded from layers II–V. The frequency of occurrence of epileptiform field potentials was reduced to 0.5 of the initial value with application of melatonin (10 and 100 nmol/l) in each case. This effect was reversible upon washing. The findings favour the hypothesis that melatonin depresses epileptiform neuronal activity through specific neocortical receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230052
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Cortico-spinal connections in the rat. I. Monosynaptic and polysynaptic responses of cervical motoneurons to epicortical stimulation (1977)
    Springer
    Experimental brain research 28 (1977), S. 385-404 
    Details
    ISSN: 1432-1106
    Keywords: Cortico-spinal connections in the rat ; Cortical motor areas ; Fast cortico-spinal fibres ; Cervical motoneurons ; Monosynaptic EPSP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In rats the fast cortico-spinal pathway and its linkage to motoneurons of the distal portions of the forelimbs were examined by electrophysiological techniques: 1. Unilateral epicortical stimulation with a single pulse led to “flick”-like movements of corresponding muscle groups in the ipsi- and contralateral limbs. The effective stimulation points of the forelimbs were localized in fronto-central areas, those of the hindlimbs in centroparietal regions of the cortex. 2. After a single epicortical stimulus a cord dorsum potential appeared in all cervical, thoracal and lumbar segments, the early part of which could be shown to reflect the activity of fast cortico-spinal fibres conducting with a velocity of 60 m/s. The sites of origin of the cortical-spinal fibres mapped by antidromic stimulation exceeded the cortical regions determined as motor areas by orthodromic stimulation in parietal and occipital direction. 3. Single stimuli applied to the ipsi- and contralateral cortical surface caused a sequence of EPSP in all studied cervical motoneurons of the distal forearm. In nearly half of the impaled neurons the first EPSP was monosynaptic. Postsynaptic reactions following ipsi- and contralateral epicortical stimulation did not show significant differences both in flexor and extensor motoneurons. A minimum increase of the stimulus intensity beyond threshold level of the first EPSP led to action potentials in the early part of the synaptic response. The results demonstrate that in non-primates, showing skilled movements of the hand and digits, a powerful direct cortico-motoneuronal connection exists which is of predominant functional significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235718
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Cortico-spinal connections in the rat. II. Oligosynaptic and polysynaptic responses of lumbar motoneurons to epicortical stimulation (1977)
    Springer
    Experimental brain research 28 (1977), S. 405-420 
    Details
    ISSN: 1432-1106
    Keywords: Cortico-spinal connections in the rat ; Lumbar motoneurons ; Oligosynaptic EPSP ; Oligosynaptic IPSP ; High frequency stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In rats the connections between cerebral cortex and lumbar motoneurons were studied by intracellular recording techniques: 1. After a single stimulus applied to the surface of the ipsi- and contralateral motor cortex (Elger et al., 1977) a sequence of postsynaptic potentials occurred consisting in an early and in a late component. 2. The early component of the postsynaptic response most often represented EPSP mediated by a pathway in which two or more neurons were interposed. In a minority of units monosynaptic EPSP appeared as well. In the case of disynaptic transmission interneurons were located at the segmental level. 3. In some motoneurons di- and multisynaptic IPSP were evoked by single ipsi- and contralateral stimuli. 4. The late component of the synaptic response represented by EPSP exceeded usually the early component in amplitude and often led to action potentials. 5. With increasing stimulus frequency the polysynaptic component fused to a sustained depolarization shift which was superimposed by the early part of the synaptic response. Parallel to the sustained neuronal depolarization the discharge frequency was transiently enhanced until spike generation failed. The results indicate that in lumbar motoneurons the polysynaptic PSP elicited by epicortical stimulation are of predominent functional significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235719
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Paroxysmal neuronal depolarizations in the rat motor cortex in vivo: intracellular injection of the calcium agonist BAY K 8644 (1986)
    Springer
    Experimental brain research 64 (1986), S. 607-609 
    Details
    ISSN: 1432-1106
    Keywords: Epilepsy ; Paroxysmal depolarization shifts ; Motor cortical neurons ; Calcium agonist BAY K 8644 ; Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Epileptic activity was elicited in the rat's motor cortex by local application of penicillin. At the neuronal level it consisted of typical paroxysmal depolarization shifts. The calcium agonist BAY K 8644 was injected into neurons showing such a discharge pattern. The application of this drug increased amplitude and afterdepolarization of paroxysmal neuronal depolarizations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00340500
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Effects of Glutamate Application on the Rhythm of Low Magnesium-induced Epileptiform Activity in Hippocampal Slices of Guinea-pigs (1996)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 8 (1996), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The extracellular concentration of glutamate has previously been reported to increase to more than 10-fold the basal level during seizure activity. In the present study, we tested whether localized increases in extracellular glutamate concentration influence the rhythm of epileptiform discharges in the low-magnesium epilepsy model. In hippocampal slices of guinea-pigs, epileptiform activity was induced by omission of magnesium from the bath fluid. Glutamate and its subreceptor agonists N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA) were ejected into different strata of the CA3 and CA1 regions using microiontophoretic and micropressure application. Glutamate, NMDA and AMPA applied to the CA3 region, but not to the CA1 region, induced a short-lasting increase in epileptiform discharge frequency, often followed by a transient reduction. The effect was most pronounced with application into the stratum lacunosum-moleculare of the CA3 region and could only be evoked in slices exceeding 400 μm in thickness. The effects on the rhythm of epileptiform discharges induced by NMDA and AMPA were blocked by their specific receptor antagonists. They were not influenced by application of GABAA and GABAB receptor antagonists. Changes in somatic membrane potential of CA3 pyramidal neurons did not correlate with changes in the rhythm of epileptiform discharges elicited in this region. The transient suppression of epileptiform discharges that followed the increase in discharge frequency was abolished by an adenosine A1 receptor antagonist. We propose that localized increases in extracellular glutamate concentration modify the rhythm of epileptiform discharges due to changes in neuronal network activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1996.tb00735.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Responses of identified neurons in the buccal ganglia of helix pomatia to stimulation of ganglionic nerves
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part A: Physiology 72 (1982), S. 643-657 
    Details
    ISSN: 0300-9629
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0300-9629(82)90142-6
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Effects of extracellularly applied proteolytic enzymes (pronase) on electrophysiological activities of identified neurons in the buccal ganglia of Helix pomatia L
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part A: Physiology 67 (1980), S. 1-7 
    Details
    ISSN: 0300-9629
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0300-9629(80)90401-6
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Structure and bioelectricity of single neurons of Helix pomatia in the intact nervous tissue during epileptic activity: Simultaneous evaluations by confocal microscopy and intracellular recordings of membrane potential changes
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part A: Physiology 106 (1993), S. 537-545 
    Details
    ISSN: 0300-9629
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0300-9629(93)90250-8
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...