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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of the aldosterone response to sodium depletion in man by stimulation of dopamine DA2 receptors (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 323-326 
    Details
    ISSN: 1432-1041
    Keywords: aldosterone ; DA2-receptor ; co-dergocrine ; hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In this study we have investigated the effect of co-dergocrine, a selective DA2-agonist, on plasma aldosterone concentrations (PAC) in twelve patients with essential hypertension both in basal conditions and during sodium depletion. Sodium depletion resulted in an increase of PAC from 38 (13) pg/ml to 297 (21) pg/ml. The PAC response to sodium depletion was reduced to 155 (29) pg/ml by co-dergocrine. No significant PAC changes were found in patients maintained on a normal sodium intake. In addition the drug did not significantly modify plasma renin activity (PRA) in either experimental group. These results suggest that the dopaminergic inhibition of aldosterone secretion in man is mediated by DA2-receptors in the adrenal cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558273
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term treatment with oral nifedipine plus theophylline in the management of chronic bronchial asthma (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 105-106 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; nifedipine ; bronchial asthma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect on bronchial smooth muscle of slow release theophylline plus placebo and theophylline plus slow release nifedipine administered for a prolonged period to 12 asthmatic and hypertensive patients has been studied. Both combinations led to a significant improvement in respiratory function parameters when compared to baseline values. No additional improvement in pulmonary function was found on long term treatment with theophylline plus nifedipine. A reduction in the number of asthmatic attacks, in the use of inhaled beta2-agonists and better control of arterial blood pressure resulted from use of theophylline plus nifedipine. That drug combination is safe and valuable in patients with chronic bronchial obstruction and cardiovascular disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870996
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of Calcium Entry Blockade on ethanol-induced changes in bronchomotor tone (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 221-222 
    Details
    ISSN: 1432-1041
    Keywords: calcium entry blockers ; bronchomotor tone ; ethanol ; nifedipine ; flunarizine ; diltiazem ; verapamil ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of various Calcium Entry Blockers (CEBs; nifedipine, flunarizine, diltiazem, verapamil) on ethanol-induced bronchoconstriction was studied in normal healthy volunteers. Nifedipine and diltiazem inhibited the bronchoconstriction and verapamil and flunarizine had no effect. The data favour the general hypothesis of differential tissue sensitivity to the various CEBs. The activity of CEBs on bronchomotor tone may be of therapeutic value in patients in whom bronchodilator activity is recommended in addition to the cardiovascular action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609695
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Reversal by the selective D-2 dopamine receptor blocker sulpiride of the hypotensive effect of co-dergocrine in elderly hypertensives (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 519-521 
    Details
    ISSN: 1432-1041
    Keywords: co-dergocrine ; sulpiride ; hypertension ; DA-2 receptors ; dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The aim of the study was to define the role of peripheral dopaminergic mechanisms in the regulation of blood pressure. The data suggest that the hypotensive effect of the dopaminergic agonist co-dergocrine in elderly hypertensive patients is mediated by interaction with peripheral DA-2 receptors, since it was reversed by the selective antagonist sulpiride in a dose that does not significantly cross the blood brain barrier. The findings suggest the possible therapeutic use of dopamine DA-2 agonists in elderly hypertensive patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544247
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    Paper (German National Licenses)
    Fulltext
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