ISSN:
1435-4373
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Susceptibility of 341 isolates of non-fermentative gram-negative bacteria to carbenicillin, piperacillin, cefoperazone, moxalactam, cefotaxime, ceftizoxime, and N-formimidoyl thienamycin was determined by the agar dilution and disc diffusion methods. Piperacillin was the most active agent againstPseudomonas aeruginosa, thienamycin the most active againstPseudomonas fluorescens andPseudomonas putida, and moxalactam the most active againstPseudomonas maltophilia. Piperacillin and thienamycin were the most active agents against the otherPseudomonas species studied. Thienamycin proved to have excellent activity againstAcinetobacter calcoaceticus − 90 % of strains were inhibited by ⩽ 1μg/ml. The two most active drugs againstAlcaligenes species were piperacillin and thienamycin, both of which inhibited 90 % of isolates at a concentration of 2μg/ ml. All drugs were active againstMoraxella species. The broad sensitivity spectrum of piperacillin, thienamycin, and the third-generation cephalosporins against non-fermentative gram-negative bacteria indicates their potential use in infections caused by these organisms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02019617
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