Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    HNO 45 (1997), S. 448-452 
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Laterobasale Frakturen ; Antibiotika ; Meningitis ; Otoliquorrhoe ; Key words Lateral basal fracture ; Antibiotic ; Meningitis ; Otoliquorrhea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A retrospective study over 5 years evaluated the medical records of 78 patients who had suffered lateral skull base fractures. The purpose of the present study was to answer the question of whether antibiotic prophylaxis reduced the risk of meningitis. Fifty-five of 78 patients (71%) were given no antibiotics, among whom four developed meningitis. In 29% of patients treated with antibiotics, two developed meningitis. This difference was not significant. Even when cases with uncomplicated („simple”) lateral skull base fractures were separated from those with severe additional lesions related to their injuries, no significant correlation was found in the occurrence of meningitis despite the use of an antibiotic. Eight of 14 patients with initial otoliquorrheas were treated with antibiotics, with two of these 8 patients developing meningitis. None of the patients who did not receive antibiotics developed meningitis. Our findings show that it is not advisible to treat patients who have suffered from lateral skull base fractures with prophylactic antibiotics. Instead, these patients should be examined frequently and appropriate antibiotic therapy prescribed at the first clinical symptoms of meningitis.
    Notes: Zusammenfassung Die Frage, ob bei laterobasalen Frakturen eine antibiotische Prophylaxe die Gefahr einer Meningitis reduziert oder nicht, wird in der Literatur kontrovers diskutiert. In einer retrospektiven Studie über 5 Jahre wurden die Krankenunterlagen von 78 Patienten mit einer Felsenbeinlängsfraktur diesbezüglich evaluiert. Untersucht wurde die Meningitisinzidenz in Abhängigkeit von der Gabe eines Antibiotikums. Bei 55 (71%) der 78 Patienten wurde kein Antibiotikum gegeben, 4 davon entwickelten eine Meningitis. Von 23 (29%) der 78 Patienten mit einem Antibiotikum bekamen zwei eine Meningitis. Dieser Unterschied der Meningitisinzidenz ist nicht signifikant. Auch bei der Unterteilung in einfache Laterobasisfrakturen und solche mit schweren Begleitverletzungen wurde kein signifikanter Zusammenhang zwischen dem Auftreten einer Meningitis und einer antibiotischen Therapie festgestellt. Von 14 Patienten mit einer nachgewiesenen initialen Otoliquorrhoe erhielten 8 ein Antibiotikum, wovon 2 eine Meningitis entwickelten. Keiner der 6 Patienten ohne ein Antibiotikum mit einer Otoliquorrhoe bekam eine Meningitis. Eine Meningitisprophylaxe ist deshalb bei Felsenbeinlängsfrakturen aus unserer Sicht nicht erforderlich. Wichtig ist jedoch, die Patienten engmaschig zu kontrollieren, um bei klinischen Zeichen einer Meningitis rasch eine antibiogrammgerechte Therapie einleiten zu können.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    HNO 46 (1998), S. 170-171 
    ISSN: 1433-0458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-2307
    Keywords: P-Glycoprotein ; Multidrug resistance ; Vesicle formation ; Daunorubicin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the human gastric carcinoma cell line EPG85-257P (parent) induction of resistance to daunorubicin (DAU) was achieved by selection with stepwise increased concentrations of the drug. The new vairant was named EPG85-257DAU and was shown to overexpress the mdr1 gene product 170 kDa P-glycoprotein (P-Gp) as demonstrated by immunocytochemistry and mdr1-specific RT-PCR. To investigate the intracellular pathway of DAU the subcellular distribution of this autofluorescent drug was studied in the resistant cells and compared to its chemosensitive counterpart EPG85-257P. When sensitive cells were exposed to DAU the drug rapidly accumulated in the nucleus until cell death. No redistribution of DAU to the cytoplasm was observed. In resistant cells exposed to the drug DAU also accumulated in the nucleus but to a lesser extent than in parent cells. Following exposure, nuclear fluorescence was observed to decrease over a time period of up to 48 h. Six hours after DAU exposure formation of fluorescent vesicle formation started in the perinuclear region and increased continously. After 48 h nuclear fluorescence was no longer detectable and DAU was located exclusively in vesicles. During this period the vesicles moved from the region of origin to the cell periphery. A pulse chase experiment showed, that vesicles may contain DAU derived from the nucleus. Treatment of EPG85-257DAU cells with DAU in conjunction with the chemosensitizer cyclosporin A (CsA) increased nuclear fluorescence without impairing vesicle formation. Disruption of microtubules by nocodazole led to an accumulation of vesicles in the perinuclear region indicating that microtubules are involved in vesicular transport. Treatment of EPG85-257DAU cells with the actin disruptor cytochalasin B led to accumulation of vesicles in the cell periphery indicating that actin may be involved in exocytosis. Uptake and efflux of DAU and rhodamin (RH) were determined in sensitive and resistant cells using a fluorescence activated cell sorter. Uptake of both compounds was distinctly lower in resistant than in sensitive cells. When resistant cells preloaded for 2 h with RH subsequently were incubated in drug free medium the substance was rapidly released indicating transmembrane transport by P-Gp. In contrast, despite expression of P-Gp in resistant cells no considerable release of DAU was observed for up to 2 h under the same experimental protocol. This indicates that in resistant cells intracellular DAU at least in part may be inaccessible for P-Gp and that vesicular drug transport appears to contribute to DAU resistance by removing intracellular DAU via exocytosis.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...