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  • 1
    Electronic Resource
    Electronic Resource
    Plasma complement changes during bronchospasm provoked in asthmatic patients (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 7 (1977), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two different groups of asthmatic patients were studied. The first group of seven reagin-mediated asthmatic patients underwent bronchial inhalation challenges with skin test positive antigen (STPA), skin test negative antigen (STNA) and methacholine. Three patients undergoing inhalation challenge with STPA showed a drop in plasma complement. In this group the drop in plasma complement was found only when the patient was challenged with STPA but not with STNA or methacholine. The second group consisted of seventeen patients, seven of whom were intolerant of aspirin (ASA) and ten asthmatic patients who experienced no untoward effects to ASA. The second group of seventeen patients was challenged with oral ASA. Venous blood samples collected during the challenges, showed a decrease in plasma complement in five patients intolerant to ASA. The ASA intolerant asthmatic patients were challenged also with either Maalox® or sodium salicylate. Only patients who ingested sodium salicylate showed a decrease in plasma complement. Activation of the alternative pathway was demonstrated in some patients. These studies demonstrated that complement activation occurred during STPA or aspirin challenges in asthmatic individuals. The role of the complement system is not clear, but it may participate in some of the pathogenetic mechanisms regulating bronchospasm through the mediations of its split products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1977.tb01439.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of leukotriene-modifier drugs on aspirin-induced asthma and rhinitis reactions (2002)
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Leukotrienes (LTs) appear to be crucial mediators of aspirin (ASA)-induced lower respiratory tract reactions. Therefore, it is logical to assume that leukotriene-modifier drugs (LTMDs) might block these reactions.Objective The aim of this study was to determine whether concomitant treatment with LTMDs was associated with a reduction of ASA-provoked lower respiratory tract reactions in patients with aspirin-exacerbated respiratory disease (AERD), when compared to AERD patients who were not treated with LTMDs. Secondly, if ASA-induced lower respiratory tract reactions were prevented in LTMD-treated patients, was there then a higher prevalence of upper respiratory reactors or, alternatively, a higher prevalence of blocked reactions (‘non-reactors’) in this group.Methods Of 271 patients suspected by history of having AERD, 96 were taking cys-LT receptor antagonists (cys-LTRAs) and 12 were taking zileuton at the time of oral ASA challenges. A matched control group of 163 patients was not receiving LTMDs. All subjects underwent standard oral ASA challenges. Reactions were classified as follows: classic [naso-ocular combined with a 20% or 〉 decline in forced expiratory volume of 1 s (FEV1)]; pure lower (20% or 〉 decline in FEV1 without naso-ocular); partial asthma (naso-ocular + 15–20% decline in FEV1); upper only (naso-ocular with 〈 15% decline in FEV1); negative (no reactions).Results In patients treated with cys-LTRAs, there were significant reductions in numbers of patients with ASA-induced bronchospastic reactions and a concomitant increase in upper respiratory reactors. There were no significant differences in mean provoking doses of ASA or the percent changes in FEV1 values in both groups. In the 12 patients receiving zileuton, no reactions to ASA (16%) were similar to the cys-LTRA-treated group (11%) and the control group (15%).Conclusion During oral ASA challenges, LTMD treatment appeared to shift target organ responses from both upper and lower respiratory tracts to upper tract alone. LTMD blocking of the entire respiratory tract did not appear to occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2745.2002.01501.x
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  • 3
    Electronic Resource
    Electronic Resource
    Oral aspirin challenges in asthmatic patients: a study of plasma histamine (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 6 (1976), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Under carefully controlled conditions, seven aspirin-intolerant asthmatic patients were challenged with oral aspirin and experienced respiratory tract reactions with a decline in forced expiratory volume in 1 sec (FEV1), ranging from 26 to 64%. Venous blood samples, which were collected during the challenges, showed a rise in plasma histamine in all seven patients. The increase in plasma histamine occurred at the onset of their respiratory reactions and those patients with the most severe asthmatic responses were found to have the highest and most prolonged levels of plasma histamine. The same aspirin-intolerant asthmatic patients were able to ingest Maalox® or sodium salicylate without untoward effects, decline in FEV1 values or changes in plasma histamine levels. Ten non-asthmatic individuals and eight out of ten asthmatic control patients were able to ingest aspirin without any reactions or changes in their plasma histamine levels. However, two asthmatic control individuals, with severe asthma requiring treatment with moderate dosages of corticosteroids, were found to have elevated pre-challenge plasma histamine levels which increased during their ASA challenges despite the absence of respiratory reactions or changes in FEV1 values. It is possible that these two individuals were unsuspected aspirin-intolerant asthmatics. These studies demonstrate that asthmatic reactions to acetylsalicylates are associated with release of histamine into plasma in the subgroup of asthmatic patients with the aspirin-intolerance syndrome. Such a finding suggests that histamine may be one of the mediators of bronchospasm in aspirin-induced asthma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1976.tb01934.x
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  • 4
    Electronic Resource
    Electronic Resource
    Pulmonary reactions to tartrazine (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 3 (1992), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In this report we have reviewed the medical literature and outlined the history of, support for and prior conclusions about adverse pulmonary reactions to tartrazine. Data obtained during oral tartrazine challenges, conducted at Scripps Clinic and Research Foundation, revealed the following: in 194 aspirin (ASA)-sensitive asthmatic patients, asthmatic attacks, occurring after ingestion of tartrazine, occurred in only one patient. Since this patient has not been available for rechallenge, using double blind protocol, we cannot definitively conclude that this patient has tartrazine induced asthmatic cross-reactivity. In the remaining six patients with initial single-blind positive challenges to tartrazine, repeat double blind challenges were subsequently negative. In 43 asthmatic patients, proven to be insensitive to ASA during oral challenges, none reacted to single blind challenges with tartrazine 50 mg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3038.1992.tb00054.x
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  • 5
    Electronic Resource
    Electronic Resource
    Oral and inhalation provocation tests for the diagnosis of
aspirin-induced asthma (2001)
    Copenhagen : Munksgaard International Publishers
    Allergy 56 (2001), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2001.00025.x
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    Paper (German National Licenses)
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