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Effect of an orally administered arotinoid, Ro 15-0778, on sebum production in man (1988)

Strauss, J. S. ; Davey, W. P. ; Denton, S. J. ; [et al.]

Springer

Archives of dermatological research 280 (1988), S. 152-154

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ISSN: 1432-069X

Keywords: Arotinoids ; Sebum production ; Acne

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary 1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-y-[(E)-alpha-methylstyryl]-naphtalene (Ro 15-0778), a potent inhibitor of sebaceous gland activity in several animal models has been administered to male volunteers in dosages of 1, 2, 3, and 6 mg/kg/day and 2 g/day for 8 weeks. Sebum production was measured before treatment and after 4 and 8 weeks of therapy. At the dosage levels of 1,2,3, and 6 mg/kg/day there was no decrease in sebum secretion. With the dosage of 2 g/day, a significant decrease in sebum secretion was seen after 8 weeks of treatment with Ro 15-0778.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00456845

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