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  • 1
    Electronic Resource
    Electronic Resource
    Liver Regeneration After Resection of Multiple Liver Cysts (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  A regenerative function is in one of the functions of liver, and if it is a normal liver, it will reproduce even to capacity almost before an operation within one year after excision. However, liver substance is pressed over the long period of time, and, as for liver cysts, a postoperative liver reproduction process is unknown. Comparison examination of the multiple liver cysts postoperative liver reproduction was carried out with after the operation.Patients:  It was aimed at one example of a multiple liver cysts operation and three metastatic live tumor (two extended left lobectomy, one right lobectomy) in this hospital. Liver volume was measured before an operation and 14 postoperative days CT, and comparison examination of the standard liver volume ratio called for from height weight was carried out.Results:  Before an operation of liver cysts and 14 postoperative day, liver volume was 151% 45 or 69% in 450 or 680 ml. Before an operation of control group and day 14 postoperative day liver volume was an average of 128% at 116 and 128 or 140% in 62, 72, 56, 71, and 49 or 68% at 618, 720, 532, 680, and 516 or 720 ml, respectively.Conclusion:  Multiple liver cysts postoperative liver reproduction was promoted compared with after the liver resection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130116u.x
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  • 2
    Electronic Resource
    Electronic Resource
    Hepatic regeneration following right lobectomy: Estimation of regenerative capacity (1994)
    Springer
    Surgery today 24 (1994), S. 44-48 
    Details
    ISSN: 1436-2813
    Keywords: major hepatectomy ; multiple regression analysis ; portal pressure ; aging ; liver cirrhosis ; chronic hepatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The regenerative capacity of the liver was assessed using a volumetric method on computed tomography in 21 adults: 16 underwent a standard right hepatic lobectomy for hepatocellular carcinoma, there were hepatic metastases in 3 others, and 2 suffered from other diseases. The patients' ages ranged from 33 to 68 years with a mean age of 57.0 years. The regeneration rate was expressed as the rate of the volume increase of the remnant left lobe compared with the preoperative volume of the left lobe. A univariate regression analysis showed that the portal pressure had a highly inverse correlation with the regeneration rate of the liver (r = −0.4753,P = 0.0397), while a multiple regression analysis demonstrated the correlation between the portal pressure, age, and the regeneration rate (multipler = 0.5640). The regeneration rate of the normal liver (97.6 ± 53.5%) was significantly higher than that of the chronic hepatitic (43.0 ± 40.7%), and also tended to be higher than that of the cirrhotic liver (51.5 ± 13.2%). However, there were no differences between chronic hepatitic and cirrhotic livers. The portal pressure before hepatectomy of the normal liver (149 ± 19 mmH2O) was significantly lower than those of chronic hepatitic (188 ± 38 mmH2O) and cirrhotic (245 ±78 mmH2O) livers. We thus conclude that the regenerative capacity of the liver following a right hepatic lobectomy could be estimated on the basis of both portal pressure and age. The regenerative capacity was also influenced by underlying liver diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01676884
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  • 3
    Electronic Resource
    Electronic Resource
    The Mechanism of Hepatic Graft Protection Against Reperfusion Injury by Prostaglandin E1 (1999)
    Springer
    Surgery today 29 (1999), S. 526-532 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: sinusoidal endothelial cell ; prostaglandin E1 ; viability ; cold preservation ; rat liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: 1 (PGE1) on protecting against hepatic endothelial cell damage and increasing graft viability after cold preservation and reperfusion, using an isolated perfused rat liver (IPRL) model. The grafts were divided into three groups, according to the cold preservation time and PGE1 administration, namely: 4 h preservation (group 1, n = 9), 6 h preservation (group 2, n = 9), and 6 h preservation followed by PGE1 infusion (group 3, n = 9). After cold storage, the grafts were put on the recirculating IPRL system, then reperfused for 120 min at 37°C with oxygenated Krebs-Henseleit buffer containing hyaluronic acid (HA). To examine the function of the sinusoidal endothelial cells and hepatocytes, serial measurements of HA, tumor necrosis factor-α (TNFα), thromboxane B2 (TXB2), acid phosphatase, and conventional parameters in the perfusate were made. After perfusion, the trypan blue exclusion test was performed to assess the presence of any microscopic sinusoidal lining cell damage. In group 3, the bile output and HA clearance were significantly greater, while glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, TNFα, TXB2, and acid phosphatase in the perfusate were significantly lower than in group 2. Histologically, less endothelial cell damage and hepatocyte damage than in group 2 was also confirmed. These results therefore suggest that the improvement of hepatic graft viability by PGE1 administration is mainly due to sinusoidal endothelial cell protection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050456
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  • 4
    Electronic Resource
    Electronic Resource
    The mechanism of hepatic graft protection against reperfusion injury by prostaglandin E1 (1999)
    Springer
    Surgery today 29 (1999), S. 526-532 
    Details
    ISSN: 1436-2813
    Keywords: sinusoidal endothelial cell ; prostaglandin E1 ; viability ; cold preservation ; rat liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to evaluate the effect of prostaglandin E1 (PGE1) on protecting against hepatic endothelial cell damage and increasing graft viability after cold preservation and reperfusion, using an isolated perfused rat liver (IPRL) model. The grafts were divided into three groups, according to the cold preservation time and PGE1 administration, namely: 4h preservation (group 1,n=9), 6h preservation (group 2,n=9), and 6h preservation followed by PGE1 infusion (group 3,n=9). After cold storage, the grafts were put on the recirculating IPRL system, then reperfused for 120 min at 37°C with oxygenated Krebs-Henseleit buffer containing hyaluronic acid (HA). To examine the function of the sinusoidal endothelial cells and hepatocytes, serial measurements of HA, tumor necrosis factor-α (TNFα), thromboxane B2 (TXB2), acid phosphatase, and conventional parameters in the perfusate were made. After perfusion, the trypan blue exclusion test was performed to assess the presence of any microscopic sinusoidal lining cell damage. In group 3, the bile output and HA clearance were significantly greater, while glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, TNFα, TXB2, and acid phosphatase in the perfusate were significantly lower than in group 2. Histologically, less endothelial cell damage and hepatocyte damage than in group 2 was also confirmed. These results therefore suggest that the improvement of hepatic graft viability by PGE1 administration is mainly due to sinusoidal endothelial cell protection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02482347
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  • 5
    Electronic Resource
    Electronic Resource
    Donor des-gamma-carboxy prothrombin positivity is a risk factor for poor early graft function in liver transplantation (1998)
    Springer
    Transplant international 11 (1998), S. 143-146 
    Details
    ISSN: 1432-2277
    Keywords: Key words Liver transplantation ; des-gamma-carboxy prothrombin ; Graft function ; des-gamma-carboxy prothrombin ; liver transplantation ; Des-gamma-carboxy prothrombin ; liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Des-gamma-carboxy prothrombin (DCP) is an abnormal prothrombin that lacks coagulating activity. The aim of this study was to determine if the presence of DCP in the donor could be used as a marker of post-transplant graft function. We collected data and serum samples on 90 organ donors. DCP level was correlated with donor-specific factors and with graft function intraoperatively and in the early post-transplant period. Twenty-seven donors (30.0 %) had positive DCP levels before harvesting. Although recipients were similar in demographics, preoperative liver function, and primary disease distribution, patients transplanted with livers from DCP-positive donors needed significantly more intraoperative transfusion. Furthermore, donor DCP positivity was identified as a preoperative risk factor for poor early graft function based on multivariate analysis (odds ratio = 6.58, P = 0.0032). Our findings suggest that DCP is another valuable marker for evaluating the quality of donor livers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050118
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  • 6
    Electronic Resource
    Electronic Resource
    The significance of tissue-type plasminogen activator for pretransplant assessment of liver graft viability: analysis of effluent from the graft in rats (1994)
    Springer
    Transplant international 7 (1994), S. 233-236 
    Details
    ISSN: 1432-2277
    Keywords: Liver graft viability, rat ; Plasminogen activator, rat, liver viability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the significance of tissue-type plasminogen activator (tPA) on the pretransplant assessment of liver graft viability in rats. The liver grafts were excised from the rats and then divided into two groups. Group 1 consisted of grafts preserved for 4 h in chilled, lactated Ringer's solution (4°C) and group 2 consisted of grafts preserved for 6 h in the same solution. After preservation, the liver grafts were flushed out through the portal vein using 5 ml of chilled, lactated Ringer's solution (4°C). The entire effluent from the hepatic veins was then collected and analyzed for tPA, ammonia, lactate, pyruvate, glutamic oxaloacetic transaminase, and lactate dehydrogenase. The tPA concentration of effluent in group 2 was significantly higher than that in group 1 (0.80±0.23 ng/ml vs 0.42±0.08 ng/ml, P〈0.05). The lactate, pyruvate, and ammonia levels in group 2 were also higher than those in group 1 (134±13 mg/dl vs 120±2 mg/dl, 0.34±0.40 mg/dl vs 0.09±0.01 mg/dl, and 183±79 μg/dl vs 102±40 μg/dl, respectively). However, the discriminative power of tPA was stronger than that of the other parameters. Histological findings revealed a higher number of trypan blue-stained sinusoidal lining cells that were detached and swollen in group 2. We conclude that the amount of tPA in the effluent flushed from the graft can serve as a sensitive and reliable indicator of cold-preserved liver grafts in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327148
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  • 7
    Electronic Resource
    Electronic Resource
    Prediction of hepatic graft viability before reperfusion: an analysis of effluent from porcine allografts (1993)
    Springer
    Transplant international 6 (1993), S. 4-7 
    Details
    ISSN: 1432-2277
    Keywords: Liver transplantation ; viability test — Viability ; liver transplantation ; pig — Venous effluent ; liver perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rapid and reliable assessment of hepatic graft viability is important for successful orthotopic liver transplantation (OLTx). OLTx was performed in 11 pairs of pigs via a venovenous bypass. Six of these grafts were transplanted immediately (group A), while the other five were preserved in University of Wisconsin (UW) solution for 24 h and then transplanted (group B). All grafts were flushed with 300 ml of chilled (4°C) Ringer's lactate solution before reperfusion of the graft, when 20 ml of effluent from the graft was collected and the concentrations of ammonia, lactic acid, GOT, and LDH were measured. Four of the six pigs in group A survived longer than 3 days, while the other two pigs died of causes other than graft dysfunction. All five pigs in group B died either of hemoperitoneum or hemodynamic instability due to liver failure. The histology of postperfusion biopsies in group A showed minimal pathological changes, while the grafts in group B revealed moderate to severe ischemic injuries. Ammonia and lactic acid in the effluent of group B were significantly higher than those of group A (1511±216 vs 417±333 μg/dl and 114.1±12.2 vs 91.4±12.2 mg/dl, respectively; P〈0.05 in both cases). Before reperfusion, the rate of total adenine nucleotides in all of the substances in the graft, which were measured using high performance liquid chromatography (HPLC), inversely correlated with the ammonia levels in the effluent. We conclude that an analysis of the effluent, (i.e. the levels of ammonia and lactic acid), flushed from a hepatic graft before reperfusion could serve as a predictor of hepatic graft viability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336630
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  • 8
    Electronic Resource
    Electronic Resource
    Serum hyaluronic acid for the assessment of graft viability in porcine liver transplantation (1994)
    Springer
    Surgery today 24 (1994), S. 719-724 
    Details
    ISSN: 1436-2813
    Keywords: hyaluronic acid ; endothelial cells ; liver transplantation ; graft viability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract For the assessment of graft viability, serum hyaluronic acid (HA) levels during porcine orthotopic liver transplantation were measured in two groups: group 1 (viable:n = 5) in which allografts were transplanted following a minimal cold (4°C) preservation, and group 2 (nonviable:n = 4) in which allografts were transplanted after cold static storage (4°C) for 24 h in University of Wisconsin solution. The changes in the HA levels reached a significant difference between the two groups at 30 min after reperfusion (P 〈 0.02). In group 1, all animals survived for over 4 days, while all animals in group 2 died within 24 h. The serum HA also demonstrated a significant correlation with prothrombin time, ß-glucuronidase, and aspartate aminotransferase at 120 min after reperfusion. These results suggest that the measurement of serum HA is a potentially effective index for evaluating hepatic allograft viability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01636778
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  • 9
    Electronic Resource
    Electronic Resource
    Multiple colorectal neoplasms in a young adult with hypogammaglobulinemia (1992)
    Springer
    Diseases of the colon & rectum 35 (1992), S. 197-200 
    Details
    ISSN: 1530-0358
    Keywords: Colorectum ; Polyp ; Polyposis ; Adenoma ; Carcinoma ; Hypogammaglobulinemia ; Immunodeficiency ; Young adult
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on a 22-year-old man with congenital hypogammaglobulinemia who developed multiple colorectal neoplasms. An immunodeficiency had been diagnosed in the patient since two years of age, and this time many tumors of the sigmoid colon and rectum were detected by barium enema and fiberscopy. Abdominoperineal resection was performed, and the resected specimen revealed 29 polyps, including 9 adenocarcinomas and 20 adenomas. The carcinomas, measuring 0.8 to 11.0 cm in size, showed various depths of invasion, and the adenomas, measuring 0.2 to 1.5 cm in size, showed various degrees of epithelial atypia. DNA analysis demonstrated that the tumors were heterogeneous, showing different DNA index and ploidy patterns. The pathogenetic relation between malignancy and immunodeficiency is also reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02050679
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