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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 19 (1997), S. 105-109 
    ISSN: 1279-8517
    Keywords: Brain asymmetry ; Fornix ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This article reports the observation that there is a left/right asymmetry of the anterior columns of the fornix in the human brain. This asymmetry is present in the position of the two columns of the fornix in relation to the septum pellucidum. The left columna fornicis was found to be located caudal to the right, and this can be readily visualized on axial MRI scans. This difference was seen in most of the subjects, but in some subjects there was no left/right-difference and in a few the asymmetry was inverse. The asymmetry of the fornix with respect to the anterior-posterior axis was independent of the well-known dissimilar lateral ventricular volumes. However, the left/right difference in the position of the fornix was evident in subjects with or without differences in ventricular volumes. This suggests that the mechanism underlying the development of asymmetry of the fornix is independent of the mechanism leading to ventricular asymmetry. So far, no functional relevance has been ascribed to such differences in location. The finding is gaining interest in connection with recent reports of asymmetries in hippocampal subfields. Studies of fornical lesions should therefore give attention to possible side-to-side differences.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 19 (1997), S. 105-109 
    ISSN: 1279-8517
    Keywords: Brain asymmetry ; Fornix ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Cet article rapporte l'existence d'une asymétrie droite/gauche des colonnes du fornix chez l'Homme. Cette asymétrie apparaît dans les plans en relation avec le septum pellucidum. Le pilier gauche du fornix apparaît en position plus caudale que le droit et ceci peut être bien visualisé sur des coupes IRM axiales. Cette différence existait chez la plupart des sujets. Chez certains, il n'y avait pas de différence gauche/droite et chez quelques sujets, l'asymétrie était inversée. L'asymétrie du fornix dans le sens antéropostérieur était indépendante de l'asymétrie bien connue des volumes ventriculaires latéraux. Quoi qu'il en soit, l'asymétrie droite/gauche de la position des piliers du fornix était évidente chez les sujets qui présentaient où ne présentaient pas de différence de volume ventriculaire. Ceci suggère que le mécanisme sousjacent du développement de l'asymétrie du fornix est indépendante du mécanisme conduisant à l'asymétrie ventriculaire. De plus, aucune conséquence fonctionnelle n'a été décrite en rapport avec de telle différence. Ces résultats sont rapprochés aux études récentes concernant les asymétries des champs hippocampiques. Les études de lésions du fornix devraient par la suite tenir compte de ces différences droite ou gauche.
    Notes: Summary This article reports the observation that there is a left/right asymmetry of the anterior columns of the fornix in the human brain. This asymmetry is present in the position of the two columns of the fornix in relation to the septum pellucidum. The left columna fornicis was found to be located caudal to the right, and this can be readily visualized on axial MRI scans. This difference was seen in most of the subjects, but in some subjects there was no left/right-difference and in a few the asymmetry was inverse. The asymmetry of the fornix with respect to the anterior-posterior axis was independent of the well-known dissimilar lateral ventricular volumes. However, the left/right difference in the position of the fornix was evident in subjects with or without differences in ventricular volumes. This suggests that the mechanism underlying the development of asymmetry of the fornix is independent of the mechanism leading to ventricular asymmetry. So far, no functional relevance has been ascribed to such differences in location. The finding is gaining interest in connection with recent reports of asymmetries in hippocampal subfields. Studies of fornical lesions should therefore give attention to possible side-to-side differences.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 19 (1997), S. 23-25 
    ISSN: 1279-8517
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Der Nervenarzt 68 (1997), S. 270-273 
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Chorea Huntington ; Epilepsie ; Zerebellumatrophie ; Antizipation ; Key words Huntington disease ; Epilepsy ; Trinucleotide repeat expansion ; Cerebellar atrophy ; Anticipation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report on a patient suffering from epilepsy and severe personality changes. Huntington disease was diagnosed by molecular-biological investigation. Clinical characteristics are discussed on the basis of modern concepts of the genetic mechanism. Neuroradiological investigation revealed marked cerebellar atrophy, while typical findings of Huntington disease, such as caudate nucleus volume loss, were lacking. The cerebellar atrophy could be attributable either to long-term phenytoin-medication or to the pathological process itself.
    Notes: Zusammenfassung Anhand einer Kasuistik wird die Koinzidenz einer Epilepsie mit einer molekularbiologisch diagnostizierten Chorea Huntington diskutiert. Die klinischen Besonderheiten im Verlauf der Erkrankung werden im Zusammenhang mit neueren Ergebnissen der molekulargenetischen Forschung bei der Chorea Huntington diskutiert. Bildgebende Diagnostik erbrachte bei dem vorgestellten Patienten einen Befund, der differentialdiagnostische Schwierigkeiten aufwirft. Es fand sich eine ausgeprägte Kleinhirnatrophie, die einerseits auf die langjährige Phenytoineinnahme zurückgeführt werden könnte, andererseits finden sich aber auch Hinweise für morphologische Veränderungen des Zerebellums bei der Chorea Huntington. Das typische Befundmuster einer Chorea Huntington mit einer Atrophie des Nucleus caudatus und daraus resultierender Verplumpung der Ventrikelvorderhörner fand sich in der Computertomographie nicht.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 250 (2000), S. 76-78 
    ISSN: 1433-8491
    Keywords: Key words Septum pellucidum ; Developmental ¶disorder ; Schizophrenia ; Magnetic resonance imaging ; Cavum veli interpositi ; Cavum septi pellucidi
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case of monocygotic twins discordant for a psychotic disorder is presented. An anomaly of the septum pellucidum, a so-called cavum veli interpositi was found in the psychotic twin while his brother showed no such anomaly. Previous studies have shown a higher prevalence of septum pellucidum anomalies in schizophrenic patients. Abnormalities of the septum pellucidum may be associated with disturbed neuronal development in distinct limbic brain areas which cannot yet be visualized yet by brain imaging techniques. The finding of the cavum veli interpositi in the psychotic twin could be incidental; however, it may indicate a dysgenic process in early brain development and, thus, play a significant role in the etiology of psychosis.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 41 (1999), S. 563-566 
    ISSN: 1432-1920
    Keywords: Key words Septum pellucidum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Absence of the septum pellucidum in the human is a rare congenital anomaly. Previous reports suggest it is almost always associated with other brain anomalies. However, MRI in two patients with absence of the septum pellucidum presented here, indicates that this anomaly may occur without associated anomalies. It may be one manifestation of a spectrum of developmental anomalies. One patient presented with schizophrenic psychosis; developmental disturbances in limbic areas are believed to be associated with schizophrenia. Agenesis of the septum pellucidum may indicate abnormal development of limbic structures and it may be associated with anomalies, such as cytoarchitectural disturbances of cortical layers, as yet undetectable by MRI.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Septum pellucidum ; Entwicklungs- störungen ; Zerebrale Fehlbildungen ; Schizophrenie ; Magnetresonanztomographie ; Key words Septum pellucidum ; Developmental disorder ; Cerebral malformations ; Schizophrenia ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Absence of the septum pellucidum is a rare developmental disorder of the human brain. Previous reports focused on the association with other cerebral anomalies. We present MRI scans showing an isolated absence of the septum pellucidum. The patient was suffering from a schizophrenic psychosis. Mental retardation or epileptic seizures, which are often found in more complex developmental brain disorders, were not observed. The septal area is part of the limbic system and aplasia of the septum pellucidum could indicate developmental anomalies of the limbic system. The concept of cerebral maldevelopment and the limbic system in schizophrenic psychosis is discussed.
    Notes: Zusammenfassung Die isolierte Aplasie des Septum pellucidum gehört zu den seltenen dysplastischen Fehlbildungen des Gehirns. Während in älteren Arbeiten das Fehlen des Septum pellucidum meistens im Zusammenhang mit weiteren zerebralen Fehlbildungen berichtet wird, so zeigen neuere Untersuchungen doch häufiger auch isolierte Aplasien ohne weitere Fehlbildungen des Gehirns. Dabei scheint ein breites Spektrum der Fehlbildungen von komplexen Hirnfehlbildungen bis hin zur einfachen Aplasie des Septum pellucidum zu reichen. Kasuistisch wird über die Aplasie des Septum pellucidum bei einem Patienten berichtet, welche kernspintomographisch im Rahmen der routinemäßig durchgeführten bildgebenden Diagnostik gefunden wurde. Klinisch wurde bei dem Patienten eine hebephrene Psychose diagnostiziert. In der Ätiologie der schizophrenen Psychosen werden dysontongenetische Mechanismen diskutiert, v.a. Migrationsstörungen in limbischen Strukturen. Eine erhöhte Inzidenz von Anomalien des Septum pellucidum, v.a. Septum-pellucidum-Zysten ist von mehreren Autoren bei schizophrenen Patienten berichtet worden. Die Bedeutung des Septum pellucidum und des Septum verum als Bestandteile des limbischen Systems werden erörtert und eine mögliche Relevanz für das Konzept der dysontogenetischen Ätiologie schizophrener Psychosen wird diskutiert.
    Type of Medium: Electronic Resource
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