Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1435-1463
    Keywords: Brain banking ; post mortem research ; schizophrenia ; affective disorders ; European consensus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The sophisticated analysis of and growing information on the human brain requires that acquisition, dissection, storage and distribution of rare material are managed in a professional way. In this publication we present the consensus of the European work group 〉European Dementia and Schizophrenia Network〈, granted by the BIOMED I project of the EU, on minimal neuropathological and clinical requirements to include brains of patients with schizophrenia and affective disorders in post mortem studies. The description of clinical prerequisites in different EU countries and institutions is followed by a consensus on tissue handling, a consensus on minimal neuropathological criteria and a consensus on minimal clinical diagnostic criteria including clinical vignette, family, social, educational/professional and general medical histories, general physical history including neurostatus, neurological, psychiatric, medication and general pathological histories, psychostatus, laboratory tests and a history provided by family/health care giver questionaire. This publication should give help to interconnect different European brain bank centers on a basis of standarized protocols.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1433-0407
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Postpartale Psychosen ; Leonhard-Klassifikation ; Zykloide Psychosen ; Motilitätspsychose ; Key words Postpartal psychoses ; Leonhard-classification ; Cycloid psychoses ; Motility psychosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In a polydiagnostic study, a systematically recruited collective of 34 women with a first-episode postpartum psychosis was reexamined after a period of 6–26 years (averaging 12.6 years) in order to establish lifetime-diagnoses according to ICD-10 and Leonhard's classification, and to determine course and outcome. According to ICD-10, unipolar depressive disorders (32%) and acute polymorphous psychotic disorders (28%) represented the most frequent diagnoses. Applying Leonhard's classification revealed a marked predominance of cycloid psychoses (62%) with the subform of motility psychosis being the most frequent diagnosis (38%). Schizophrenias occurred rarely according to both classifications. Investigating the long-term course, we found in 59% multiphasic disorders. The mean number of episodes per patient was 2.5 (range 2–6) with a mean duration of 9.8 weeks (SD=5.2). 6 patients (18%) had undergone a monophasic course, in 4 cases (12%) the course was not determinable. 17 women (50%) had 19 further deliveries during the follow-up period. The frequency of relapses in connection with a further delivery was 47%. Administering the Strauss-Carpenter-Outcome-Scale revealed a favourable outcome with a mean value of 14.1 (SD=2.83) for our total sample. Only 4 patients (12%) had never recovered fully since the onset of the illness. Our findings suggest that cycloid psychoses, in particular motility psychoses, account for the majority of postpartum psychoses, and do not support the hypothesis of a nosological independence of postpartum psychoses. They provide further evidence of a favourable prognosis of severe postpartum psychiatric disorder despite a relatively high rate of non-puerperal and especially puerperal relapses.
    Notes: Zusammenfassung 34 Patientinnen, bei denen eine endogene Psychose erstmals postpartal aufgetreten war, wurden im Mittel 12,6 Jahre (6–26 Jahre) nach Erkrankungsbeginn nachuntersucht. In einem polydiagnostischen Ansatz erfolgte eine Klassifikation nach den Kriterien der ICD-10 und nach Leonhard, um die Häufigkeit bestimmter Diagnosen zu ermitteln. Innerhalb der ICD-10 zeigte sich eine Verteilung auf ein breites Spektrum von Störungen mit unipolaren depressiven Störungen (32%) und akuten polymorphen psychotischen Störungen (28%) als häufigsten Diagnosen. Die Anwendung der Leonhard-Klassifikation ergab dagegen ein klares Dominieren zykloider Psychosen (62%) und hierbei insbesondere der Subform der Motilitätspsychosen (38%). Schizophrenien waren entsprechend beider Klassifikationen selten. Die Erkrankungen verliefen überwiegend multiphasisch (59%); nur in 6 Fällen (18%) waren monophasische Verläufe zu beobachten, bei 4 Patientinnen (12%) war eine genaue Bestimmung nicht möglich. Die durchschnittliche Anzahl der Phasen betrug 2,5 (2–6) bei einer mittleren Dauer von 9,8 (SD=5,2) Wochen. 17 Patientinnen (50%) hatten 19 weitere Entbindungen, von denen 47% mit einem Rezidiv der Erkrankung verbunden waren. Der Ausgang war insgesamt sehr günstig mit einem Mittelwert von 14,1 (SD 2,83) für das Gesamtkollektiv auf der Strauss-Carpenter-Skala. Lediglich 4 Patientinnen (12%) wiesen einen Verlauf ohne Vollremission und mit Ausbildung einer Residualsymptomatik auf. Unsere Ergebnisse sprechen gegen eine nosologische Eigenständigkeit postpartaler Psychosen. Vielmehr machen zykloide Psychosen und hierbei insbesondere Motilitätspsychosen den größten Teil postpartaler Psychosen aus. Trotz einer deutlichen Neigung zu Rezidiven, insbesondere auch in Verbindung mit weiteren Entbindungen, ist die Prognose insgesamt günstig.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 250 (2000), S. 76-78 
    ISSN: 1433-8491
    Keywords: Key words Septum pellucidum ; Developmental ¶disorder ; Schizophrenia ; Magnetic resonance imaging ; Cavum veli interpositi ; Cavum septi pellucidi
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case of monocygotic twins discordant for a psychotic disorder is presented. An anomaly of the septum pellucidum, a so-called cavum veli interpositi was found in the psychotic twin while his brother showed no such anomaly. Previous studies have shown a higher prevalence of septum pellucidum anomalies in schizophrenic patients. Abnormalities of the septum pellucidum may be associated with disturbed neuronal development in distinct limbic brain areas which cannot yet be visualized yet by brain imaging techniques. The finding of the cavum veli interpositi in the psychotic twin could be incidental; however, it may indicate a dysgenic process in early brain development and, thus, play a significant role in the etiology of psychosis.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 245 (1995), S. 135-141 
    ISSN: 1433-8491
    Keywords: Schizophrenia ; Periodic catatonia ; Inheritance ; Anticipation ; Leonhard classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a family study involving 139 probands with DSM-III-R catatonic schizophrenia and 543 first-degree relatives, we investigated age-specific morbidity risk according to Leonhard's clinical distinction between systematic and periodic catatonia. This dichotomy is based on different types of symptomatology, course, and outcome. In systematic catatonia the age-corrected morbility risk was 4.6%. In periodic catatonia, however, there was an age-corrected morbidity risk with homogenous psychoses of 26.9%, and more parents than siblings were affected. This points strongly to a major gene effect in periodic catatonia. Furthermore, a pairwise comparison of patients and their parents revealed patterns of anticipation, i.e., the probands' age at the onset of disease was significantly earlier than that of their parents (P〈0.001). Similarly, anticipation was apparent in pedigrees with three successive generations affected. This inheritance pattern with homogenous psychoses and anticipation indicates that genes with trinucleotid repeat expansion or other repetitive elements affecting gene expression may be involved in the etiology of periodic catatonia. Thus, periodic catatonia as a specific clinical subtype of schizophrenia is a promising candidate for molecular genetic evaluation.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Schizophrenie ; Leonhard-Klassifikation ; Kataphasie ; Formale Denkstörungen ; Sprachliche Störungen ; Key words Schizophrenia ; Leonhard classification ; Cataphasia ; Formal thought disorder ; Speech disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Cataphasia, one form of Leonhard’s unsystematic schizophrenias, shows a polymorphous, but nevertheless specific symptomatology. The key features of the psychopathology of this condition are formal thought and speech disorders. Hallucinations and delusional ideas can be present, but they are incidental and do not determine the syndrome. The characteristic elements of this thought disorder are logical derailment, paralogic thinking and, especially in the excited form, incoherence with contaminations up to ”word salad”. The speech shows strange verbalizations, paragrammatisms, agrammatisms, and occasionally neologisms. The course mostly fluctuates with acute attacks and incomplete remissions, leading to residual states of varying degrees of severity determined by a flattened and somewhat euphoric affect. Usually the disorder appears in an excited or inhibited form. In the latter case, thought disorder is difficult to recognize. Sometimes it can only be stated by the facial expression, which reveals an internal emptiness and dullness, and a tendency to stare fixedly at the examiner. Psychopharmacotherapy can diminish accompanying delusional ideas or hallucinations, but does not have much influences on the core syndrome of formal thought and speech disorder.
    Notes: Zusammenfassung Anhand kasuistischer Beispiele wird die Kataphasie, eine Form der unsystematischen Schizophrenien Leonhards, in ihrem vielgestaltigen, dabei aber doch stets charakteristischen Bild dargestellt. Zentrales Element der Erkrankung sind Störungen des formalen Denkens mit starker Beteiligung der sprachlichen Ebene. Halluzinationen und inhaltliche Denkstörungen kommen vor, dominieren jedoch niemals das Syndrom. Die Denkstörung ist gekennzeichnet durch logische Entgleisungen, paralogische Denkschritte und, vorwiegend in akuten Schüben mit erregter Ausgestaltung, durch Inkohärenz mit Kontaminationen bis hin zum „Wortsalat”. Auf sprachlicher Ebene finden sich para- und agrammatische Formulierungen, Wortentstellungen, Wortvergreifungen mit Verfehlung des kontextadäquaten Bedeutungsgehaltes und nicht selten unsinnige Neologismen. Der Verlauf gestaltet sich meist schubweise unter Ausbildung eines Defektzustandes mit gewöhnlich guter und freundlicher Zuwendung bei leicht verflachtem, eher heiterem Affekt. Die Störung manifestiert sich üblicherweise in erregter oder gehemmter Form, wobei in der gehemmten Form bei spärlichen bis fehlenden sprachlichen Äußerungen die Denkstörung v.a. an den Verhaltensweisen, geprägt von Ratlosigkeit bei leerem Gesichtsausdruck und oftmals stumpfem Fixieren des Gegenübers, zu erkennen ist. Psychopharmakologisch lassen sich die formalen Denkstörungen nicht wesentlich beeinflussen, dagegen begleitende inhaltliche Denkstörungen und Halluzinationen häufig eindämmen.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Septum pellucidum ; Entwicklungs- störungen ; Zerebrale Fehlbildungen ; Schizophrenie ; Magnetresonanztomographie ; Key words Septum pellucidum ; Developmental disorder ; Cerebral malformations ; Schizophrenia ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Absence of the septum pellucidum is a rare developmental disorder of the human brain. Previous reports focused on the association with other cerebral anomalies. We present MRI scans showing an isolated absence of the septum pellucidum. The patient was suffering from a schizophrenic psychosis. Mental retardation or epileptic seizures, which are often found in more complex developmental brain disorders, were not observed. The septal area is part of the limbic system and aplasia of the septum pellucidum could indicate developmental anomalies of the limbic system. The concept of cerebral maldevelopment and the limbic system in schizophrenic psychosis is discussed.
    Notes: Zusammenfassung Die isolierte Aplasie des Septum pellucidum gehört zu den seltenen dysplastischen Fehlbildungen des Gehirns. Während in älteren Arbeiten das Fehlen des Septum pellucidum meistens im Zusammenhang mit weiteren zerebralen Fehlbildungen berichtet wird, so zeigen neuere Untersuchungen doch häufiger auch isolierte Aplasien ohne weitere Fehlbildungen des Gehirns. Dabei scheint ein breites Spektrum der Fehlbildungen von komplexen Hirnfehlbildungen bis hin zur einfachen Aplasie des Septum pellucidum zu reichen. Kasuistisch wird über die Aplasie des Septum pellucidum bei einem Patienten berichtet, welche kernspintomographisch im Rahmen der routinemäßig durchgeführten bildgebenden Diagnostik gefunden wurde. Klinisch wurde bei dem Patienten eine hebephrene Psychose diagnostiziert. In der Ätiologie der schizophrenen Psychosen werden dysontongenetische Mechanismen diskutiert, v.a. Migrationsstörungen in limbischen Strukturen. Eine erhöhte Inzidenz von Anomalien des Septum pellucidum, v.a. Septum-pellucidum-Zysten ist von mehreren Autoren bei schizophrenen Patienten berichtet worden. Die Bedeutung des Septum pellucidum und des Septum verum als Bestandteile des limbischen Systems werden erörtert und eine mögliche Relevanz für das Konzept der dysontogenetischen Ätiologie schizophrener Psychosen wird diskutiert.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1435-1463
    Keywords: Association study ; B37 CAG repeat locus ; chromosome 12 ; schizophrenia ; periodic catatonia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical evidence for a dominant mode of inheritance and anticipation in periodic catatonia, a distinct subtype of schizophrenia, indicates that genes with triplet repeat expansions or other unstable repetitive elements affecting gene expression may be involved in the etiology of this disorder. Because patients affected with dentatorubral-pallidoluysian atrophy (DRPLA) may present with “schizophrenic” symptoms, we have investigated the DRPLA (B 37 CAG repeat) locus on chromosome 12 in 41 patients with periodic catatonia. The B 37 CAG repeat locus was highly polymorphic but all alleles in both the patient and control group had repeat sizes within the normal range. We conclude that variation at the DRPLA locus is unlikely to be associated with periodic catatonia. The evidence for dominant inheritance and anticipation as well as the high prevalence of human brain genes containing trinucleotide repeats justifies further screening for triplet repeat expansions in periodic catatonia.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...