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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 281 (1989), S. 173-177 
    ISSN: 1432-069X
    Keywords: Ki-67 antigen ; Mitotic rate ; Human melanomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated whether two parameters of proliferative activity — mitotic rate and Ki-67 positive cells — are interchangeable. The mitotic rate was assessed on paraffin-embedded sections, Ki-67 positive cells were immunohistologically determined in frozen tissue. A poor correlation (correlation coefficient r=0.57) was found between both parameters. The proliferative activity was often not homogeneously distributed in the tested tumors. However, this is a major reason for the observed difference only in thin melanomas (〈1.5 mm) as seen by comparison of tumors with homogeneous and inhomogeneous proliferative activity. We assume that arrest of cells in different stages of the cell cycle — variable from melanoma to melanoma — is the major reason for the observed discrepancy between mitotic rate and Ki-67 positive cells in tumors of 1.5 mm and thicker. The mean number of Ki-67 positive cells increased with tumor thickness. The stability of the Ki-67 antigen towards freezing, thawing, and formalin was studied.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 57 (1986), S. 2100-2100 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A series of direct drive implosions of D-T filled, glass microballoons has been initiated in an effort to produce intense neutron sources for diagnostics development. In particular, measurements such as neutron imaging, burn history using a neutron-sensitive streak camera, and fuel ρr by both neutron activation and neutron spectroscopy could be more easily tested with these simple targets than high-density targets that initially are not expected to produce such high yields. Targets with nominal dimensions of 1000×2 μm which contained D-T at 12–14 atm were imploded with 18 kJ of 0.35-μm light from the 10-beam Nova system. For pulse widths of 1 ns in either converging or diverging geometry, fusion yields in excess of 1013 have been obtained. The yields are comparable to those predicted from numerous 1-D model calculations in spite of the asymmetric illumination geometry of the driver. Work performed under the auspices of the U.S. DOE by Lawrence Livermore National Laboratory under contract number W-7405-ENG-48.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 59 (1988), S. 1801-1803 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Experiments to obtain time-resolved, soft-x-ray emission from laser-driven plasmas are succinctly described. The spectra (0.19 keV ≤ hν ≤ 1.3 keV) at various times have been deconvolved and energy integrated to obtain time-resolved yields from Au disk targets. The temporal profiles of the total thermal x-ray output power follow the overall laser temporal shape but do not show the high-frequency fluctuation observed in the laser pulse. The behavior of the ratio of the instantaneous x-ray yields over the laser absorption is studied. The studies were done at the LLNL Nova laser facility. Single pulses and pulses in "picket fence'' configuration were used to heat the gold targets.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Measurements of radiation temperatures from empty and gas-filled hohlraums heated at the Nova Laser Facility [E. M. Campbell et al., Laser Part. Beams 9, 209 (1991)] show efficient coupling of the laser power to the target when applying laser beam smoothing techniques. Scattering losses are reduced to the 3% level while the radiation temperatures increased by ∼15 eV for smoothed laser beams. The experimental findings and supporting calculations indicate that filamentation and gain for stimulated Raman and Brillouin scattering is suppressed in the hohlraum plasma for smoothed laser beams. The scaling of the radiation temperature is well described by integrated radiation hydrodynamic LASNEX modeling [G. B. Zimmerman and W. L. Kruer, Comments Plasma Phys. Controlled Fusion 2, 85 (1975)] following the Marshak scaling. Peak radiation temperatures are in excess of 230 eV in gas-filled hohlraums in agreement with the detailed LASNEX modeling. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 7 (2000), S. 2023-2032 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Laser–plasma interactions are sensitive to both the fine-scale speckle and the larger scale envelope intensity of the beam. For some time, simulations have been done on volumes taken from part of the laser beam cross-section, and the results from multiple simulations extrapolated to predict the behavior of the entire beam. However, such extrapolation could very well miss effects of the larger scale structure on the fine-scale. The only definitive method is to simulate the entire beam. These very large calculations have not been feasible until recently, but they are now possible on massively parallel computers. Whole beam simulations show the dramatic difference in the propagation and break up of smoothed and aberrated beams.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The original ignition "point designs" (circa 1992) for the National Ignition Facility (NIF) [J. A. Paisner, E. M. Campbell, and W. J. Hogan, Fusion Technol. 26, 755 (1994)] were made energetically conservative to provide margin for uncertainties in laser absorption, x-ray conversion efficiency and hohlraum-capsule coupling. Since that time, extensive experiments on Nova [J. T. Hunt and D. R. Speck, Opt. Eng. 28, 461 (1989)] and Omega [J. M. Soures et al., Phys. Plasmas 3, 2108 (1996)] and their related analysis indicate that NIF coupling efficiency may be almost "as good as we could hope for." Given close agreement between experiment and theory/modeling, one can credibly explore target enhancements which couple more of NIFs energy to an ignition capsule. These include using optimized mixtures of materials to reduce x-ray wall losses, slightly reduced laser entrance holes, and laser operation strategies which increase the amount of energy one can extract from NIF. It is found that 3–4× increases in absorbed capsule energy appear possible, providing a potentially more robust target and ∼10× increase in capsule yield.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Diffusive supersonic radiation transport, where the ratio of the diffusive radiation front velocity to the material sound speed 〉2 has been studied in experiments on low density (40 mg/cc to 50 mg/cc) foams. Laser-heated Au hohlraums provided a radiation drive that heated SiO2 and Ta2O5 aerogel foams of varying lengths. Face-on emission measurements at 550 eV provided clean signatures of the radiation breakout. The high quality data provides new detailed information on the importance of both the fill and wall material opacities and heat capacities in determining the radiation front speed and curvature. The Marshak radiation wave transport is studied in a geometry that allows direct comparisons with analytic models and two-dimensional code simulations. Experiments show important effects that will affect even nondiffusive and transonic radiation transport experiments studied by others in the field. This work is of basic science interest with applications to inertial confinement fusion and astrophysics.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A necessary condition for igniting indirectly driven inertial confinement fusion (ICF) capsules on the National Ignition Facility (NIF) is controlling drive asymmetry to the 1% level [S. W. Haan, S. M. Pollaine, J. D. Lindl et al., Phys. Plasmas 2, 2480 (1995)]. Even flux-asymmetry modes (e.g., Legendre modes P2, P4, P6, and P8) must be reduced by hohlraum design and laser beam pointing. Odd flux-asymmetry modes (e.g., Legendre modes P1, P3, P5, etc.) are theoretically removed by reflection symmetry across the hohlraum midplane [S. M. Pollaine and D. Eimerl, Nucl. Fusion 38, 1523 (1998)], but will be produced by power imbalance, laser beam pointing errors, and target fabrication errors. An experimental campaign is now being conducted on the University of Rochester's Omega laser to measure higher order (P4 and higher) flux asymmetry modes inside hohlraums that approximate the conditions of a NIF hohlraum during the 90 eV early drive phase [S. W. Haan, S. M. Pollaine, J. D. Lindl et al., Phys. Plasmas 2, 2480 (1995)]. These experiments use a new point-projection backlighting technique [O. L. Landen, D. R. Farley, S. G. Glendinning et al., Rev. Sci. Instrum. 72, 627 (2001)] to cast high quality 4.7 keV radiographs of thin 2 mm diameter Ge-doped CH shells designed to enhance sensitivity to drive asymmetries. Distortions in the position of the limb of the shells resulting primarily from drive asymmetries are measured to an accuracy of 2 μm. The linearity and sensitivity of thin imploding shells to flux asymmetry makes it possible to achieve this degree of accuracy, which is sufficient for NIF ignition symmetry tuning. The promising results to date permit the comparison of measured and predicted distortions and, by inference, drive asymmetries for the first eight asymmetry modes. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 8 (2001), S. 2908-2917 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Several techniques for inferring the degree of flux symmetry in indirectly driven cylindrical hohlraums have been developed over the past several years for eventual application to the National Ignition Facility (NIF) [Paisner et al., Laser Focus World 30, 75 (1994)]. These methods use various ignition capsule surrogates, including non-cryogenic imploded capsules [Hauer et al., Phys. Plasmas 2, 2488 (1995)], backlit aerogel foamballs [Amendt et al., Rev. Sci. Instrum. 66, 785 (1995)], reemission balls [Delamater, Magelssen, and Hauer, Phys. Rev. E 53, 5240 (1996)], and backlit thinshells [Pollaine et al., Phys. Plasmas 8, 2357 (2001)]. Recent attention has focussed on the backlit thinshells as a promising means for detecting higher-order Legendre flux asymmetries, e.g., P6 and P8, which are predicted to be important sources of target performance degradation on the NIF for levels greater than 1% [Haan et al., Phys. Plasmas 2, 2490 (1995)]. A key property of backlit thinshells is the strong amplification of modal flux asymmetry imprinting with shell convergence. A simple single-parameter analytic description based on a rocket model is presented which explores the degree of linearity of the shell response to an imposed flux asymmetry. Convergence and mass ablation effects introduce a modest level of nonlinearity in the shell response. The effect of target fabrication irregularities on shell distortion is assessed with the rocket model and particular sensitivity to shell thickness variations is shown. The model can be used to relate an observed or simulated backlit implosion trajectory to an ablation pressure asymmetry history. Ascertaining this history is an important element for readily establishing the degree of surrogacy of a symmetry target for a NIF ignition capsule. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Laser beam smoothing by spectral dispersion and by polarization smoothing has been observed to significantly reduce the scattering losses by stimulated Brillouin and stimulated Raman scattering from inertial confinement fusion hohlraums. For these measurements, the laser beam smoothing and the high-Z hohlraum wall plasma parameters approach the conditions of future inertial confinement fusion experiments. The simultaneous application of the smoothing techniques has reduced the scattering losses by almost one order of magnitude down to the 1% level. The experimental scaling of the stimulated Brillouin reflectivity compares well to modeling assuming nonlinear damping on the ion acoustic waves in three-dimensional nonlinear wave simulations and calculated hohlraum plasma conditions from radiation-hydrodynamic modeling. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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