ISSN:
1434-4475
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Sila-analoguesA 2,B 2 andC 2 of the drug mebrophenhydramine from the class of benzhydryl ethers were synthesized for the first time by the steps shown in scheme 1, and they and their precursors I–III were characterized by their physical (Table 1) and chemical properties, and their structures confirmed by NMR, mass and infrared spectroscopy (Tables 3–5). The histaminolytic and anticholinergic effects ofA 2 andC 2 were investigated and compared with some structure-activity relationships of analogue carbon compounds.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00906873
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