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  • 1
    Digitale Medien
    Digitale Medien
    ROLE OF NITRIC OXIDE IN IMPAIRED CORONARY CIRCULATION AND IMPROVEMENT BY ANGIOTENSIN II RECEPTOR ANTAGONIST IN SPONTANEOUSLY HYPERTENSIVE RATS (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. To determine whether coronary flow regulation by nitric oxide (NO) is impaired in the hypertensive heart (HTH), coronary perfusion was measured in isolated rat hearts using NO synthesis inhibitor L-NG-monomethyl arginine (L-NMMA) in Wistar-Kyoto (WKY) rat and spontaneously hypertensive rat (SHR) with and without chronic Nω-nitro-L-arginine-methylester (L-NAME) treatment. Moreover, the effect of angiotensin 11 receptor antagonist (AT1 receptor antagonist) (TCV-116) on the impaired coronary circulation in HTH was examined.2. Coronary flow (CF) was decreased in HTH accompanied with cardiac hypertrophy. The decreased response of CF to L-NMMA infusion was diminished in HTH. It is suggested that NO production was reduced in coronary vasculature in HTH.3. In chronic L-NAME treated SHR, blood pressure and cardiac hypertrophy were accelerated. Although coronary flow resistance (CFR) was increased, the increased response of CFR to L-NMMA infusion was not altered.4. The AT1 antagonist improved total minimal coronary flow resistance (MCFR) restoring CFR response in SHR, although it did not recover CFR response in chronic L-NAME treated SHR.5. Taken together the findings suggest that NO production was exhausted in the coronary artery even in the developing stage of hypertension and this exhaustion could contribute to the impairment of coronary circulation of HTH.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb02858.x
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  • 2
    Digitale Medien
    Digitale Medien
    FUNCTIONAL ALTERATION OF THE GABAB RECEPTOR IN THE BRAIN OF SPONTANEOUSLY HYPERTENSIVE RATS (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. We studied the ontogenetic development of GABAB receptors and their coupling to cyclic AMP formation in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rat brains. GABAB receptor binding to various brain regions was compared in age-matched SHR and WKY rats.2. The specific [3H]-GABA binding to the posterior hypothalamus (PH) was significantly lower in not only 4 week old (normotensive) but also 11 week old (hypertensive) SHR, when compared with age-matched WKY.3. Moreover, GABAB receptor agonists (baclofen and DN-2327)-induced suppression of adenylate cyclase activity also showed a decrease in 4 week old and 11 week old SHR PH.4. We concluded that the number and the functional responsiveness of GABAB receptors in rat brains decrease in SHR, preceding blood pressure elevation. The activity of GABABergic mechanisms may be different in the brains of SHR and WKY rats.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb02967.x
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  • 3
    Digitale Medien
    Digitale Medien
    ROLE OF BAROREFLEX AND CENTRAL α2-ADRENERGIC RECEPTOR SYSTEMS IN THE DIURNAL VARIATION OF BLOOD PRESSURE AND HEART RATE IN NORMOTENSIVE AND HYPERTENSIVE RATS (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. To elucidate whether baroreflex could contribute to manifest the diurnal blood pressure variations (DBPV) in normotension and hypertension, DBPV were recorded continuously via a femoral artery in awake normotensive (NT) rats and spontaneously hypertensive rats (SHR) with and without sinoaortic denervation (SAD). To determine the role of central cuzadrenergic receptor system in DBPV in hypertension, guanabentz (0.5–1.0 μg/kg per min) was infused in SHR.2. There were no differences in mean arterial pressure (MAP) variability (SD) of MAP of 24 h (MAP—SD/MAP) and SD of 24 h heart rate (HR—SD/HR) between SHR and NT. SAD did not elevate MAP and HR in both SHR and NT.3. However, in SAD rats, MAP—SD/MAP was significantly greater than those in sham-operated rats in both SHR and NT, while MAP—SD/MAP and HR—SD/HR did not show any difference between the two groups even after SAD. On the other hand, SAD did not augment HR—SD/HR in either strain.4. During guanabentz infusion, MAP was significantly lowered in sham-operated and SAD–-SHR. Moreover, MAP –-SD/MAP was significantly reduced in sham-operated, but it was not in SAD–-SHR.5. These findings suggest that baroreflex could suppress tonically the diurnal change of blood pressure in NT and SHR. The regulation of diurnal blood pressure by baroreflex via a central a-adrenergic receptor system may be altered in SHR.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb02972.x
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  • 4
    Digitale Medien
    Digitale Medien
    Effects of gibberellin and colchicine on microfibril arrangement in epidermal cell walls of Vigna angularis Ohwi et Ohashi epicotyls (1981)
    Springer
    Planta 151 (1981), S. 393-398 
    Details
    ISSN: 1432-2048
    Schlagwort(e): Cell elongation ; Cell-wall growth ; Cellulose microfibrils ; Colchicine ; Gibberellin ; Vigna
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Gibberellic-acid (GA3) treatment of azukibean epicotyls resulted in alterations of the direction of newly deposited microfibrils, on the cell walls. Cells having transverse microfibrils on the inner surface of the wall were observed more frequently in GA3-treated epicotyls than in untreated or water-treated ones. This effect of GA3 was negated by simultaneously supplied colchicine. A crossed polylamellate structure was observed in the inner portion of the walls of GA3-treated cells, but not in the inner portion of the walls of colchicine-treated cells. The wall formed under the influence of colchicine consisted of microfibrils running in the same direction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00393297
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  • 5
    Digitale Medien
    Digitale Medien
    Changes in microfibril arrangement on the inner surface of the epidermal cell walls in the epicotyl of Vigna angularis ohwi et ohashi during cell growth (1981)
    Springer
    Planta 151 (1981), S. 385-392 
    Details
    ISSN: 1432-2048
    Schlagwort(e): Cell elongation ; Cell-wall growth ; Cellulose microfibrils ; Vigna
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Throughout the entire period of cell growth, the microfibrils on the inner surface of the outer tangential walls of the epidermal cells of Vigna angularis epicotyls are running parallel to one another and their orientation differs from cell to cell. Although transverse, oblique and longitudinal microfibrils can be observed irrespective of cell age, the frequency distribution of microfibril orientation changes with age. In young cells, transversely oriented microfibrils predominate. In cells of medium age, which are still undergoing elongation, transverse, oblique and longitudinal microfibrils are present in quite similar frequencies. In old, non-growing cells, longitudinally oriented microfibrils are predominent. A decrease in the relative frequency of transversely oriented microfibrils with cell age was also observed in the radial epidermal walls.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00393296
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  • 6
    Digitale Medien
    Digitale Medien
    Interaction of tyrosine residues with the chromophore in bacteriorhodopsin (1985)
    Springer
    Bioscience reports 5 (1985), S. 615-623 
    Details
    ISSN: 1573-4935
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract We previously reported that the absorption spectrum at low temperatures of iodinated bacteriorhodopsin can be separated into four components with maxima at shorter wavelengths than in native bacteriorhodopsin. In this study, the time course of the formation of each spectral component after iodination was analyzed, revealing that these four components correspond to four different iodinated states of tyrosine residues interacting with the retinal chromophore of bacteriorhodopsin. Therefore at least two tyrosine residues interact with the chromophore of bacteriorhodopsin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01117075
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  • 7
    Digitale Medien
    Digitale Medien
    Significance of the β-Subunit in the Biogenesis of Na+/K+-ATPase (1997)
    Springer
    Bioscience reports 17 (1997), S. 173-188 
    Details
    ISSN: 1573-4935
    Schlagwort(e): Na+/K+-ATPase ; H+/K+-ATPase ; β-subunit ; subunit assembly ; disulfide bond ; Xenopus oocyte
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract This review summarizes our experiments on the significance of the β-subunit in the functional expression of Na+/K+-ATPase. The β-subunit acts like a receptor for the α-subunit in the biogenesis of Na+/K+-ATPase and facilitates the correct folding of the α-subunit in the membrane. The α-subunit synthesized in the absence of the β-subunit is subjected to rapid degradation in the endoplasmic reticulum. Several assembly sites are assigned in the sequence of the β-subunit from the cytoplasmic NH2-terminal domain to the extracellular COOH-terminus: the NH2-terminal region of the extracellular domain, the conservative proline in the third disulfide loop, the hydrophobic amino acid residues near the COOH-terminus and the cysteine residues forming the second and the third disulfide bridges. Upon assembly, the β-subunit confers a resistance to trypsin on the α-subunit. The conformations induced in the α-subunit of Na+/K+-ATPase by Na+/K+- and H+/K+-ATPase β-subunits are somehow different from each other and are named the NK-type and KH-type, respectively. The extracellular domain of the β-subunit is involved in the folding of the α-subunit leading to trypsin-resistant conformations. The sequences from Cys150 to the COOH-terminus of the Na+/K+-ATPase β-subunit and from Ile89 to the COOH–terminus of the H+/K+-ATPase β-subunit are necessary to form trypsin-resistant conformations of the NK- and HK-type. respectively. The first disulfide loop of the extracellular domain of the β-subunits is critical in the expression of functional Na+/K+-ATPase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1027333529412
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  • 8
    Digitale Medien
    Digitale Medien
    Investigation of the relationship between regression of hypertensive cardiac hypertrophy and improvement of cardiac sympathetic nervous dysfunction using iodine-123 metaiodobenzylguanidine myocardial imaging (1996)
    Springer
    European journal of nuclear medicine 23 (1996), S. 756-761 
    Details
    ISSN: 1619-7089
    Schlagwort(e): Hypertensive cardiac hypertrophy ; antihypertensive therapy ; Regression ; Iodine-123 metaiodobenzylguanidine ; Cardiac sympathetic nervous dysfunction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Although many theories exist on the subject, the mechanisms responsible for a reduction of hypertensive cardiac hypertrophy in response to antihypertensive therapy are still unclear. In order to investigate the relationship between regression of hypertensive cardiac hypertrophy and cardiac nervous function, we studied ten patients with untreated essential hypertension (six men and four women, 62±12 years old). Both echocardiography and iodine-123 metaiodobenzylguanidine (MIBG) myocardial imaging were performed before and after antihypertensive therapy. Left ventricular mass (LVM) was significantly reduced in conjunction with the reduction of blood pressure following treatment. MIBG myocardial images showed that the heart-to-mediastinum activity ratio (H/M) was significantly increased while the washout ratio was significantly decreased. Patients were divided into two groups according to the ratio of the LVM values before and after therapy (LVM ratio). Patients with an LVM ratio of less than 0.75 were classified as group A and those with values higher than 0.75 as group B. Neither the change in blood pressure nor the length of treatment was significantly different between these two groups. On the other hand, both the increase in H/M and the decrease in the washout ratio were significantly greater in group A than in group B. These results indicate that an improvement in cardiac sympathetic nervous function may be related to the regression of hypertensive cardiac hypertrophy. Increasing the subject base in these studies and a more precise analysis of the relevance of the data obtained from MIBG myocadial images are recommended to clarify how changes in cardiac sympathetic nervous function relate to the regression of hypertensive cardiac hypertrophy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00843703
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  • 9
    Digitale Medien
    Digitale Medien
    Photoreaction of tyrosin-iodinated bacteriorhodopsin at low temperature (1982)
    Springer
    Bioscience reports 2 (1982), S. 949-958 
    Details
    ISSN: 1573-4935
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract To elucidate the role of tyrosine residues in the shift of λmax and the light-driven proton pump of bacteriorhodopsin~ the photochemical reaction of tyrosine-iodinated bacteriorhodopsin (tyr-mod-bR) was investigated by low-temperature spectrophotometry. After 4–5 of 11 tyrosine residues of bacteriorhodopsin were iodinated, the meta-intermediate of tyr-mod-bR in 75% glycerol solution became so stable that its decay could be observed even at room temperature and i t was stable in the dark for several hours at −65°C. Four batho-intermediates were formed by irradiation with green light (500 nm) at −170°C. Like native bacteriorhodopsin, these batho-intermediates were photoreversible at −170°C. Four corresponding meta-intermediates were also formed by irradiation at −60°C. Using the difference spectra between meta-intermediates and tyr-mod-bR, the absorption spectra of four kinds of tyr-mod-bRs, batho-intermediates, and meta-intermediates were estimated. Each was at shorter wavelengths than that of its corresponding type in native bacteriorhodopsin. The results indicate that two or more tyrosine residues have some role in determining color in native bacteriorhodopsin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01114902
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