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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 44 (1988), S. 906-907 
    ISSN: 1420-9071
    Keywords: Ascidian ; tunicate ; vanadium ; vanadocyte ; blood cell ; fluorescence ; vanadium accumulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A tunichrome that has been suggested to be involved in the accumulation of vanadium ions in ascidian blood cells produces an autonomous fluorescence upon excitation with blue-violet light. However, we have found that signet ring cells, which contain large amounts of vanadium, do not fluoresce upon such excitation. The strongest fluorescence due to the tunichrome was observed in morula cells, which do not contain vanadium.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0942-0940
    Keywords: Brain tumour ; chemotherapy ; induced hypertension ; xenon-enhanced CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Changes in tumour blood flow under an induced hypertensive state were examined in malignant brain tumours to know if the precondition for the effectiveness of induced hypertensive chemotherapy — relative increase in tumour blood flow — are fulfilled. Tumour blood flow was measured under both a resting and an induced hypertensive state in 12 patients with various malignant brain tumours (6 gliomas, 6 metastatic brain tumours) using xenon-enhanced computed tomography. The blood pressure was elevated 40% above the systemic blood pressure of the resting state by the infusion of angiotensin II. Tumour blood flow increased 30% on average above the normal brain tissue blood flow after the induction of an induced hypertensive state (p 〈 0.05). The tumour blood flow increased in 11 cases of malignant tumours, but decreased in one case with massive brain oedema after induced hypertension. The increase in blood flow was higher in hypervascular tumours and less in hypovascular tumours. Therefore, induced hypertensive chemotherapy probably will be more effective in hypervascular malignant brain tumours with small mass effects.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0942-0940
    Keywords: Angiogenic factor bFGF ; dural AVF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Purpose Dural arteriovenous fistulas (dAVFs) are known to be acquired disorders. Angiogenic stimulants, such as basic fibroblast growth factor (bFGF), may be involved in the evolution of this disorder. We examined the appearance and localization of bFGF, in human dAVF sinuses, versus a control using immunohistochemical techniques, to evaluate these qualitative differences. Patients and methods Four human dural sinuses from dAVF patients, and one control dural sinus were removed at surgery or autopsy and used for this study. Immunohistochemistry for bFGF was performed in all five specimens to identify its appearance and localization. Immunohistochemistry for alpha smooth muscle actin, factor VIII related antigen, and macrophage (CD-68) were done in all tissues to identify the bFGF positive cell types. Results In the control dural sinus, there was negative staining by bFGF immunohistochemistry. However, in all four sinuses of the dAVF patients, smooth muscle cells, endothelial cells, and meningeal cells were stained positively in various degrees by bFGF immunohistochemistry. Conclusion bFGF may be significant in the development of dAVFs, judging from its strong immunoreactivity in the sinuses of dAVF patients.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0942-0940
    Keywords: Keywords: Hyperperfusion syndrome; percutaneous transluminal angioplasty; transcranial doppler.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  We report 2 cases with haemorrhagic complications following percutaneous transluminal angioplasty (PTA) for carotid stenosis. Computed tomography (CT) scanning of these cases demonstrated diffuse subarachnoid haemorrhage in 1 case, and intracerebral haemorrhage in the other case on the next day after PTA. In the latter case, we measured cerebral blood flow velocity and mean transit time with transcranial doppler (TCD) and dynamic CT scan, which demonstrated remarkable increases in the blood flow velocity and peak height, respectively. From these results, postoperative hyperperfusion was suggested to have caused haemorrhagic complications.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0942-0940
    Keywords: Keywords: Internal carotid artery; dissecting aneurysm; stent; ultrasound imaging.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  We present a case of a cervical internal carotid artery aneurysm that caused cerebral embolism. This lesion was supposed to be a dissecting aneurysm due to blunt neck injury. The large aneurysm with intramural thrombus was treated with endovascular placement of a balloon-expandable stent. Both CT and MRI were useful for evaluating the size and characteristics of the aneurysmal wall. Intravascular ultrasound imaging was also useful for evaluation of the satisfactory stent deployment and identification of the neck of the aneurysm. We disscuss effectiveness of endovascular stenting for cervical internal carotid artery aneurysm with intramural thrombus and the usefulness of a combination of the neuroradiological imaging before, during and after the interventional procedure.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 141 (1999), S. 663-665 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0942-0940
    Keywords: Interventional neuroradiology ; papaverine ; percutaneous transluminal angioplasty ; subarachnoid haemorrhage ; vasospasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Purpose The effect of endovascular treatment for vasospasm was investigated by analysing the results of patients treated in Wakayama City in 1994. Materials and Methods Ninty nine patients with ruptured cerebral aneurysms, who survived more than one week and were treated in Wakayama City in 1994, were studied. Twenty five patients caused symptomatic vasospasm and 25 were treated by endovascular therapy, percutaneous transluminal angioplasty (PTA) and/or intra-arterial papaverine infusion (IAP). PTA was performed for proximal vasospasm which located in the main arterial trunk, such as ICA, M1, BA (n = 3). IAP was chosen for distal vasospasm which located mainly in the M2, A1, A2 (n = 12). PTA and/or IAP was performed for diffuse vasospasm which located in proximal and distal arteries (n = 10). Results In the proximal vasospasm group, all patients were good to moderately disabled on the Glasgow outcome scale (GOS). In the distal vasospasm group, 8 patients were good to moderately disabled, and 4 patients were severely disabled. The overall results were as follows: 17 (68%), good to moderately disabled, 4 (16%), severely disabled, 4 (16%), dead. The morbidity and mortality rate was 8/25 (32%) in symptomatic spasm group. Conclusion PTA was very effective especially for proximal vasospasm, but IAP was not always effective for distal or diffuse vasospasm. Diffuse vasospasm revealed a high mortality rate in spite of the endovascular therapy.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0942-0940
    Keywords: Keywords: Arteriovenous fistula; oestrogen; female; rat; venous hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Purpose: Dural arteriovenous fistulae (AVF) represent abnormal communication between the meningeal arteries and the dural sinuses. Clinically, this condition appears more frequently in post-menopausal and pregnant women than in the general population. Oestrogen is believed to play an important role in the development of dural AVF; however, its exact role has not been clearly defined. We have previously reported that by surgically creating a carotid-jugular shunt in male rats, which then induces venous hypertension, spontaneous arteriovenous fistulae can result. To examine the specific role that oestrogen may have in the development of AVF induced by venous hypertension, we performed the following experimental procedure. Materials and methods: Ninety-four Sprague-Dawley female rats (250–300 grams in weight) were randomly assigned to four different groups. Group 1 (n=20): control (bilateral ovariectomy only). Group 2 (n=19): bilateral ovariectomy and implantation of the oestrogen pellet (17-β oestradiol 0.75 mg/pellet, 60 days release). Group 3 (n=17): bilateral ovariectomy and venous hypertension (left carotid-jugular shunt with proximal jugular vein occlusion). Group 4 (n=38): bilateral ovariectomy and oestrogen pellet implantation and venous hypertension. All of the groups were examined by angiography 60 days after treatment. In Groups 1 and 2, bilateral common carotid angiography was performed via a transfemoral route. In Groups 3 and 4, angiography was done after sugical ligation of the carotid-jugular shunt to examine for any newly developed AVF. Results: No newly developed AVF were found in either Groups 1, 2, or 3. In Group 4, 2 rats (5.3%) developed newly formed AVF which occurrred in the nose and neck. Our previous study demonstrated that AVF appeared in 3 of 22 (13.6%) venous hypertensive male rats. Therefore, no statistical difference in the appearance rate of newly formed AVF was found among groups 1, 2, 3 or 4 and between our previously reported group of male venous hypertensive rats. Conclusion: In this experimental study, ovariectomy with or without oestrogen did not affect the development of spontaneous AVF induced by venous hypertension.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0942-0940
    Keywords: Balloon Matas test ; dynamic computerized tomography ; internal carotid artery occlusion ; giant aneurysm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Temporary occlusion of the internal carotid artery with a balloon atheter (balloon Matas test) and simultaneous dynamic computerized tomography scanning (DCT) were performed to determine the tolerance of permanent carotid occlusion in eight cerebral aneurysm and two carotid-cavernous fistula (CCF) cases, in whom internal carotid occlusion might be necessary during operation or as a choice of treatment. All patients were evaluated by mean transit time (MTT), especially % transit time (MTT of the occluded side×100/MTT of the control side). In six patients, % transit time (%TT) was less than 155 and no neurological signs appeared after permanent internal carotid occlusion. Neurological deficit appeared when mean arterial blood pressure was 80, and disappeared when mean arterial blood pressure was 100 during the balloon Matas test in a case whose %TT was 200. Neurological deficit appeared several seconds after the balloon Matas test in a case whose %TT was 250. The critical %TT value to cause symptomatic ischaemia was 200 from our results. Therefore, it is necessary to undertake treatment such as bypass surgery for the patients whose %TT is near 200, even if the balloon Matas test was negative.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 15 (1993), S. 119-123 
    ISSN: 1279-8517
    Keywords: Cancer cell coexistence ; Colliding tumor ; Immunohistochemical double staining ; Lymph system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs décrivent la coexistence dans un même noeud lymphatique de cellules tumorales provenant de deux cancers différents. L'observation est celle d'un sujet masculin de 83 ans décédé d'une lymphangite carcinomateuse pulmonaire cinq mois après gastrectomie pour cancer. L'autopsie montra l'existence de métastases lymphonodales d'un cancer prostatique. Histologiquement, les métastases du cancer prostatique présentaient un aspect cribriforme tandis que les cellules d'origine gastrique dessinaient des formations papillaires et tubulaires. En immunohistochimie les premières se révélaient positives à l'antigène prostatique spécifique (PSA), et les autres à l'antigène carcino-embryonnaire (ACE). Cinquante et un noeuds rétropéritonéaux et pelviens furent examinés : la coexistence des deux types de cellules métastatiques fut observée dans deux noeuds. Les deux types se retrouvaient associés au niveau du hile, fait confirmé par les réactions immunohistochimiques. Les deux noeuds intéressés étaient situés dans la région préaortique et latéro-aortiques gauche et appartenaient au groupe des noeuds proximaux qui collectent à la fois la lymphe des organes pelviens et celle des organes digestifs intra-abdominaux.
    Notes: Summary The coexistence of two differently originating cancer cells within the same lymph node is reported. An 83-year-old male patient died from severe carcinomatous lymphangitis of the lungs five months after gastrectomy for gastric cancer. At autopsy, prostatic cancer metastasis to lymph node was found. Histologically, the prostatic carcinoma cells had a cribriform pattern and the gastric cells showed papillary and tubular features. Immunohistochemically, the former was immunoreactive to prostate specific antigen (PSA) and the latter was stained positively for carcinoembryonic antigen (CEA). Fifty-one of the retroperitoneal and intrapelvic lymph nodes were histologically examined; the coexistence of both types of cancer cells was found in two lymph nodes. Both types were adjoined at the hilum, as was also confirmed by an immunohistochemical double staining technique. These two lymph nodes were located in the pre-aortic and left lateral aortic areas, and they belonged to the terminal lymph node group of both the intra-pelvic and intra-abdominal intestinal organs.
    Type of Medium: Electronic Resource
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