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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 803 (1996), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7373
    Keywords: brain tumors ; cystemustine ; nitrosourea ; relapse ; survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study included 39 patients (37 evaluable, of whom 30 patients with recurrent gliomas and 7 patients with gliomas untreated by radiotherapy); they were enrolled into a phase II trial using a new nitrosourea, cystemustine, administrated every 2 weeks at 60 mg/m2 as a 15 min-infusion. Pathology at inclusion was (WHO classification): 14 glioblastomas, 20 grade 3–4 astrocytomas and 3 grade 3 oligodendrogliomas. Four partial responses have been obtained, giving an overall response rate of 10.8%. Four additional patients had a partial response, which for various reasons was not confirmed 4 weeks later; 12 patients had a stable disease for at least 8 weeks, 15 patients had progressive disease. Of the 4 responses, 2 were with a grade 3 oligodendroglioma and 2 glioblastoma. Toxicity (WHO grading) was mainly hematological: leukopenia (16.2% grade 3–4), neutropenia (29.7% grade 3–4), thrombopenia (27% grade 3–4). No other toxicity greater than grade 2 was observed. In conclusion, cystemustine at 60 mg/m2 has moderate clinical activity in relapsing glioma. Our results warrant further investigation of this agent with an increased dose or modified scheme.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 10 (1997), S. 329-341 
    ISSN: 0894-3370
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: The dynamic analysis of discontinuities in printed circuits has been performed using the mode matching technique. This study concerns the open end of microstrip lines and suspended microstrip lines. The fields on either side of the discontinuity are described by means of the continuous (radiated and evanescent) and guided modes of the structure.The conditions of continuity of the electromagnetic fields are then applied in the plane of the discontinuity. By taking into account the relations of orthogonality of the modes of the same region, a system of coupled Fredholm integral equations is obtained and solved by the iterative method of Neumann's series.The study calls for the use of the continuous spectrum of microstrip lines, which can be obtained analytically only after a great amount of calculation and CPU time. Thus, the first approach consists in neglecting this continuous spectrum. This gives accurate results for the reflection coefficient but it is not sufficient for the derivation of the radiation pattern. So, two simple models for the continuous spectrum, both based on the physical behaviour of such discontinuities, are considered and discussed. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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