ISSN:
1432-1041
Keywords:
azapropazone
;
arthritis
;
pharmacokinetics
;
synovial fluid level
;
synovial tissue level
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The concentration-time curves of azapropazone in synovial fluid and tissues have been studied in arthritic patients after an i.v. bolus (600 mg) and under steady-state conditions. Synovial fluid and tissue samples were taken intraoperatively 0.45–60 h after administration. The azapropazone concentrations in synovial fluid, synovial tissue and plasma were correlated. The levels in synovial fluid were usually lower than corresponding plasma levels. Under steady-state conditions azapropazone did not accumulate in synovial tissues.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00607579
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