ISSN:
1612-1112
Keywords:
Supercritical fluid chromatography
;
ß-Blockers
;
Solvation with supercritical CO2
;
New chiral phase
;
Chiral separation
;
Chiral resolution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary High-speed separation of β-blockers have been successfully obtained (analysis time 〈 2 min) using a short column packed with ChyRoSine-A CSP. Peculiar chromatographic behaviour of β-blockers on tyrosinederived CSPs under supercritical conditions was evidenced by studying the curves of hversus the linear velocity u. Specific solvation of solutes by supercritical carbon dioxide is responsible for the particular conformation of the molecular of β-blocker which enhances chiral discrimination. This was evidenced by using the reciprocality concept leading to a new CSP derived from a propranolol analogue. Thus, it was demonstrated that SFC can be used for the fast chiral separation of β-blockers.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02274582
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