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  • 1
    Electronic Resource
    Electronic Resource
    Efficacy of blood purification therapy for heat stroke presenting rapid progress of multiple organ dysfunction syndrome: a comparison of five cases (1999)
    Springer
    Intensive care medicine 25 (1999), S. 315-318 
    Details
    ISSN: 1432-1238
    Keywords: Key words Heat stroke ; Multiple organ dysfunction syndrome ; Blood purification therapy ; Continuous venovenous hemofiltration ; Plasma exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Five patients were admitted to our hospital because of classical heat stroke during the heat waves which attacked our country in the summers 1994 and 1995. The clinical and laboratory findings of all patients suggested the rapid progress of multiple organ dysfunction syndrome (MODS). Blood purification (BP) therapy, in addition to conventional treatment, was performed in three of the patients. Despite their disastrous general condition, all completely recovered or recovered sufficiently to be transferred to a rehabilitation hospital. Two additional patients were treated with conventional treatment only and both died in 1–3 days after admission.Clinical characteristics and laboratory findings on admission showed no differences between the cases receiving BP therapy and those not receiving BP therapy. These findings suggest that, in heat stroke patients, additional BP therapy may provide a better prognosis than conventional therapy only. These beneficial effects of BP may have been due mainly to the removal of proinflammatory cytokines related to heat stroke.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050842
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  • 2
    Electronic Resource
    Electronic Resource
    Low-temperature noncontact atomic-force microscope with quick sample and cantilever exchange mechanism (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 2971-2976 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We present the design and performance of a noncontact atomic-force microscope (AFM) operating at low temperatures (LTNCAFM). For the first time, a "top bath" cryostat is used to avoid long-distance translation of the AFM unit, while protecting the fragile optical fiber, and to reduce outgassing. The top bath cryostat is optimized by using three radiation shields with two shutters. The AFM unit is cooled down to 5 K for 14 h with 4.6 l liquid helium. The quick sample and cantilever exchange is performed even at low temperatures. The optimal positioning of the optical fiber with respect to a cantilever can be performed with a three-dimensional micropositioner within 10 min. The high performance of the LTNCAFM is demonstrated with an atomically resolved image of a Si(111)7×7 surface. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1368854
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  • 3
    Electronic Resource
    Electronic Resource
    Dual effect of estrogen on glomerular injury in hypercholesterolemic male Imai rats: its regulation by testosterone (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 300-305 
    Details
    ISSN: 1437-7799
    Keywords: Key words Ovariectomy ; Estrogen ; Testosterone ; Rats ; Glomerulosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Hypercholesterolemic Imai rats, especially males, spontaneously develop proteinuria and glomerulosclerosis. We previously studied the effect of estrogen on the development of glomerular injury in this rat strain and found that estrogen treatment showed a sex difference in its effect on glomerular injury, exerting dual effect, an attenuating effect in males and an exacerbatory effect in females. Because this dual effect seemed to be related to and regulated by testosterone, in the present study, we investigated whether estrogen's effect on glomerular injury differed in the presence and absence of testosterone, using castrated male Imai rats in experiment 1 (Exp 1), and testosterone-replaced castrated Imai rats in Exp 2. Methods. In Exp 1, groups (G)1 and 2 were sham-operated and G3 and 4 were castrated at 6 weeks of age. G2 and 4 received estrogen. In Exp 2, G1 was sham-operated and G2 was castrated. G3 and 4 were castrated and received testosterone replacement therapy with G4 receiving additional estrogen therapy. Body weight, urinary protein, and serum constituents were investigated every 4 weeks, from 12 weeks through 24 weeks of age. At 24 weeks of age, the rats were studied morphologically. Results. Estrogen treatment of control male rats attenuated glomerular injury to levels equal to those in castrated rats, but, conversely, the same treatment in castrated rats exacerbated the glomerular injury, with an increase in serum growth hormone (GH) levels. In Exp 2, testosterone replacement therapy abolished the attenuating effect of castration but estrogen treatment of testosterone-replaced castrated rats attenuated the glomerular injury with a reduction in serum GH levels. Conclusions. The results suggest that a dual, attenuating and exacerbatory, effect of estrogen on glomerular injury is regulated by testosterone, and that up-regulation of GH by estrogen may contribute to the exacerbatory effect of estrogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570070005
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    Paper (German National Licenses)
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