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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 13 (1989), S. 313-315 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La déconnection porto-azygos, comprenant la ligature veineuse et la suture pariétale hémostatique circonférentielle du pôle supérieur de l'estomac, est une technique simple et rapide pour contrôler efficacement l'hémorragie provenant de varices oesophagiennes. Sa basse mortalité chez le patient opéré en urgence ou à haut risque en fait une technique utile en cas de non réponse au traitement conservateur, y compris la sonde de tamponnement oesogastrique et la sclérothérapie. Dans cet article, nous concluons que les résultats à long terme de cette opération prouvent qu'elle peut également être utilisée dans la chirurgie à froid surtout chez le patient classé Child “C.” La survie chez les patients ayant atteint un taux avancé de cirrhose est de 0% à 5 ans. Ils peuvent bénéficier de cette déconnection portale car l'intervention ne perturbe pas les hémodynamiques du système porte et, par conséquent n'induit pas d'encéphalopathie chronique.
    Abstract: Resumen La desconexión porta-azigos utilizando ligaduras venosas y una sutura hemostásica circunferencial de la pared gástrica a nivel del polo superior es una técnica simple y rápida que controla en forma efectiva el sangrado de várices esofagogástricas. Su baja tasa de mortalidad en casos de emergencia o en pacientes de alto riesgo puede ser de gran beneficio en casos que no hayan respondido a terapia conservadora, incluso taponamiento y esclerosis venosa. En este artículo presentamos los resultados de esta operatión a largo plazo que demuestran que también puede ser utilizada en casos electivos, especialmente en pacientes en la clase “C” de Child. Estos pacientes con cirrosis avanzada exhiben una muy baja supervivencia (no mayor de 5 años); sin embargo pueden beneficiarse con esta desconexión portal, puesto que el procedimiento no altera la hemodinamia portal y, por consiguiente, no induce encefalopatía crónica.
    Notes: Abstract Portal azygos disconnection, using vein ligatures and a circumferential hemostatic suture of the gastric wall at the level of the upper pole, is a simple and a rapid technique that effectively controls bleeding from esophagogastric varices. Its low mortality rate in emergency cases or poor-risk patients can be of great benefit to patients who have not responded to conservative therapy, including tamponade and vein sclerosis. In this article, we conclude that the long-term results of this operation demonstrate that it can also be used in elective cases, especially in patients with Child's “C” classification. These patients with advanced cirrhosis have a very low survival rate (no more than 5 years) yet they can benefit from this portal disconnection since this procedure does not alter the portal hemodynamics and, consequently, does not induce chronic encephalopathy.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-4919
    Keywords: vitamin D3 ; etoposide ; topoisomerase inhibitors ; differentiation ; receptor expression ; myeloid cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The simultaneous administration of the DNA topoisomerase II inhibitor etoposide (0.15 mM) and 1,25-dihydroxyvitamin D3 (VD3) (10 nM) synergistically induced the differentiation of HL-60 human promyelocytic leukemia cells. Similar results were obtained using U-937 human promonocytic cells, or the topoisomerase II inhibitors doxorubicin (15 nM) and mitoxantrone (2.5 nM). When sequential treatments were used, pre-incubation with VD3 had little effect on the subsequent action of etoposide, while pre-incubation with etoposide greatly potentiated the subsequent action of VD3. In addition, etoposide treatment stimulated VD3 binding activity and increased VD3 receptor mRNA and protein levels. The increase in hormone receptor expression may explain, at least in part, the capacity of topoisomerase inhibitors to potentiate the differentiation inducing activity of VD3.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-2592
    Keywords: Non-Hodgkins malignant lymphoma ; human T cell leukemia virus-1 (HTLV-1) ; CD40 ; Bgp95 ; T cell ; baboon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Papio hamadryas baboons in the Sukhumi colony develop enzootic outbreaks of malignant lymphomas with an incidence of about 1.5% per year among adults of the high-risk stock. We investigated the surface phenotypes of cells from normal and lymphomatous animals using antibodies against human lymphocyte antigens. We found that more than 80% of the lymphomas that developed during the last 3 years were characterized histologically to be of the peripheral T cell type. Generally, the lymphomatous cells also expressed high levels of MHC class II DR protein, CD18 (LFA-1 beta chain), and CD45RO. Surprisingly, these cells also expressed on their surface two proteins previously characterized as being relatively B cell-restricted: CD40 and Bgp95. These proteins were never found on the peripheral blood T cells from normal animals. The expression of these two gene products was confirmed by RNA blotting and immunoprecipitation. In most cases, the two B cell-associated proteins were expressed on the predominant T cell subsets; we found both B cell proteins on CD4+, CD8+ as well as on the CD4/8 double-positive cells when these subsets were expressed at high levels. About 90% of these animals are seropositive forHerpesvirus papio and human T cell leukemia virus-1 (HTLV-1) before developing outright lymphomas. In all of the lymphoma samples, HTLV-1 tax DNA sequences were detected by PCR amplification. Whether or not HTLV-1 or theHerpesvirus papio gene products influence the surface expression of CD40 and Bgp95 remains to be determined.
    Type of Medium: Electronic Resource
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