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  • 1
    Electronic Resource
    Electronic Resource
    Apomorphine anorexia: the role of dopamine receptors in the ventral forebrain (1988)
    Springer
    Psychopharmacology 96 (1988), S. 135-141 
    Details
    ISSN: 1432-2072
    Keywords: Apomorphine ; Sulpiride ; SCH-23390 ; Central drug administration ; Dopamine autoreceptors ; Feeding behaviour ; Microstructural analysis ; Eating rate ; Eating time ; Open field ; Nucleus accumbens ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The inhibition of feeding following the administration of apomorphine, systemically or directly into the nucleus accumbens/ventral striatum, was studied using a microstructural analysis paradigm. On systemic administration, apomorphine reduced food consumption, eating rate and eating time; the effects were blocked by sulpiride but not by SCH-23390. Two doses of apomorphine were administered centrally. Both doses reduced total food intake and eating rate; only the higher dose also reduced eating time; all of these effects were blocked by sulpiride pretreatment. Only the lower dose reduced locomotor activity and rearing in the open field. The results suggest that apomorphine reduces eating rate by an action on dopamine (DA) axon terminal autoreceptors. We have previously demonstrated that apomorphine reduces eating time by an action on DA cell body autoreceptors. Therefore, the two populations of DA autoreceptors appear to be differentially involved in behaviour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02431545
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Apomorphine anorexia: A behavioural and neuropharmacological analysis (1985)
    Springer
    Psychopharmacology 87 (1985), S. 351-356 
    Details
    ISSN: 1432-2072
    Keywords: Apomorphine ; Haloperidol ; Thioridazine ; Central drug administration ; Dopamine ; Feeding behaviour ; Microstructural analysis ; Eating rate ; Eating time ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Anorectic effects of apomorphine were studied in a microstructural analysis paradigm. Low doses of apomorphine (〈0.1 mg/kg SC) reduced food intake, by reducting both the rate of eating and eating time. The neuroleptics haloperidol and thioridazine blocked the effect of apomorphine on eating time, but not on eating rate. Anorectic effects elicited by apomorphine administration to the ventral tegmental area and, to a lesser extent, the substantia nigra were mediated by a selective reduction of eating time. Effects of apomorphine on eating time appear to result from an action at presynaptic dopamine receptors; the mechanism of the effect of apomorphine on eating rate is unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432720
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Apomorphine anorexia: The role of dopamine cell body autoreceptors (1986)
    Springer
    Psychopharmacology 89 (1986), S. 65-68 
    Details
    ISSN: 1432-2072
    Keywords: Apomorphine ; Sulpiride ; Central drug administration ; Dopamine ; Autoreceptors ; Feeding behaviour ; Microstructural analysis ; Eating rate ; Eating time ; Ventral tegmental area ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Anorectic effects of apomorphine were studied in a microstructural analysis paradigm. Systemic apomorphine reduced food intake by reducing both the rate of eating and the time spent eating. Peripheral administration of sulpiride reversed the apomorphine effect on both eating rate and eating time but central administration of this neuroleptic into the ventral tegmental area (VTA) selectively reversed the apomorphine effect on eating time, sparing eating rate. Administration of apomorphine directly into the VTA reduced eating time but not eating rate; the effect on eating time was blocked by peripheral sulpiride. The results imply that the two components of apomorphine anorexia result from actions at different sites. Effects of apomorphine on eating time appear to result from an action on DA cell body autoreceptors. The apomorphine effect on eating rate appears to be mediated elsewhere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175191
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in dopamine autoreceptor sensitivity in an animal model of depression (1988)
    Springer
    Psychopharmacology 94 (1988), S. 545-550 
    Details
    ISSN: 1432-2072
    Keywords: Stress ; DMI ; Sucrose preference ; Microstructural analysis ; Apomorphine ; Eating time ; Eating rate ; Dopamine autoreceptors ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats exposed for 6 weeks to a variety of mild unpredictable stressors showed reduced consumption of a preferred sucrose solution. The deficit was apparent after 1 week of stress and was maintained for at least 2 weeks after termination of the stress regime. Sucrose preference was unaffected by 2 weeks of treatment with the tricyclic antidepressant DMI but returned to normal after 3 weeks of DMI treatment. Subsensitivity to the anorexic effect of a low dose of apomorphine was seen in vehicle-treated stressed animals, and in unstressed animals following withdrawal from DMI. In both cases, the changes resulted from a failure of apomorphine to reduce eating time (rather than from changes in eating rate); this effect is assumed to represent a subsensitive response to stimulation of dopamine cell body autoreceptors. As the same effect is seen in anhedonic stressed animals and in animals withdrawn from DMI, it is concluded that dopamine autoreceptor desensitization probably does not contribute to clinical improvement following chronic antidepressant treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212853
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Dopamine autoreceptors in the ventral tegmental area show subsensitivity following withdrawal from chronic antidepressant drug treatment (1986)
    Springer
    Psychopharmacology 90 (1986), S. 64-71 
    Details
    ISSN: 1432-2072
    Keywords: DMI ; Amitriptyline ; Mianserin ; Chronic drug administration ; Dopamine ; Autoreceptors ; Apomorphine ; Central drug administration ; Feeding behaviour ; Microstructural analysis ; Eating time ; Rat ; Ventral tegmental area ; Antidepressant drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The suppression by apomorphine of food intake and eating time was used to assay the sensitivity of dopamine cell body autoreceptors during the course of treatment with DMI, amitriptyline and mianserin. Brief (2–4 days) DMI treatment enhanced the effects of apomorphine, administered systemically or centrally to DA cell body regions. During chronic DMI treatment (3–7 weeks) some evidence of autoreceptor subsensitivity was observed with systemic apomorphine, but not with central apomorphine. Responses to apomorphine applied systemically were reduced during withdrawal from chronic DMI, and responses to apomorphine applied to the ventral tegmental area were reduced during withdrawal from all three antidepressants. As evidence of DA autoreceptor subsensitivity was only observed reliably during withdrawal, this effect is unlikely to be of clinical importance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172873
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    Paper (German National Licenses)
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