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  • 1
    Electronic Resource
    Electronic Resource
    Effects of Short- and Long-Term Protriptyline Treatment on Phospholipid Metabolism in Rat Brain (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 44 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Wistar rats were injected intraperitoneally with 10 mg/kg of protriptyline according to one of the following schedules: a single dose or daily for 4 days (short-term), or daily for 2 or 13 weeks (long-term). Total lipid, total phospholipid, and individual phospholipid contents in the brain were determined. Further, the incorporation of 32P into individual phospholipids in vivo and the fatty acid composition of phosphatidylethanolamine in the brains of rats treated with protriptyline for 13 weeks were studied. Three alternative phases of changes of total and individual phospholipid contents in the brain during 13 weeks of experimentation were distinguished. An increase of phospholipid contents after 4 days, a decrease after 2 weeks, and a further increase after 13 weeks of protriptyline administration were found. However, phosphatidylinositol and phosphatidic acid levels after 13 weeks of protriptyline administration were diminished. The decrease of specific radioactivity of phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine and the increase of phosphatidylinositol, phosphatidic acid, and sphingomyelin in rats treated with the drug for a longer period of time were noted. No greater differences in fatty acid composition of phosphatidylethanolamine in the brains of the same group of rats were observed as compared to control. These results indicate that during long-term treatment with protriptyline the contents of lipids and phospholipids in rat brain are altered. The modification of the biological function of phospholipids in brain cell membranes is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb05429.x
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of prolonged amphetamine treatment and amphetamine withdrawal on brain biogenic amine content and behaviour in the rat (1971)
    Springer
    Psychopharmacology 21 (1971), S. 74-81 
    Details
    ISSN: 1432-2072
    Keywords: Amphetamine ; 9 Months Treatment ; Rat, Behavioural and Biochemical Phenomena ; Amphetamine Withdrawal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Male Wistar rats were treated orally with D-l-amphetamine sulphate in a dose of 3 mg/kg daily during 9 months. An increase of locomotor activity during the first 3 months was observed, while in the following 6 months locomotor activity was similar to the control group. The estimations of noradrenaline and 5-hydroxytryptamine levels in 9 discrete areas of brain, after 9 months of amphetamine treatment showed no changes in 5-HT level, but a significant decrease of the noradrenaline level in the pons. Withdrawal of amphetamine from rats treated for 9 months with this drug caused an inhibition of locomotor activity and a decrease of noradrenaline and 5-hydroxytryptamine level in the cerebellum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403998
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of neuroleptics on phospholipase A2 activity in the brain of rats (1995)
    Springer
    European archives of psychiatry and clinical neuroscience 245 (1995), S. 179-182 
    Details
    ISSN: 1433-8491
    Keywords: Neuroleptic treatment ; Rats ; Phospholipase A2 ; Brain plasma membranes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of neuroleptics on phospholipase A2 (PLA2) activity in rat brain plasma membranes was studied. Chlorpromazine (10 mg/kg), fluphenazine (5 mg/kg), thioridazine (5 mg/kg), trifluoperazine (5 mg/kg), haloperidol (2 mg/kg), and sulpiride (100 mg/kg) were administered to rats intraperitoneally as a single dose or long-term treatment (4 weeks). The PLA2 activity was determined 24, 48, and 72 h after the last injection of a drug. The enzyme activity was decreased after a single or 4-week administration of chlorpromazine, trifluoperazine, haloperidol, and sulpiride. Fluphenazine and thioridazine caused an increase of PLA2 activity in rat brain both after a single dose and long-term administration. For the first time it was shown that neuroleptics cannot only inhibit but also increase, PLA2 activity. Elucidation of this fact requires further studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02193092
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  • 4
    Electronic Resource
    Electronic Resource
    The influence of 1-(o-Allylphenoxy)-3-Isopropylamino-2-Propanol Hydrochloride (Alprenolol) on the central nervous system of the rat (1971)
    Springer
    Psychopharmacology 21 (1971), S. 66-73 
    Details
    ISSN: 1432-2072
    Keywords: Alperenolol ; Amphetamine ; Brain Amines ; Behaviour ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of alprenolol and amphetamine alone or combined on the content of noradrenaline, dopamine and 5-hydroxytryptamine in seven discrete areas of the brain and on rat behaviour was studied. Animals were treated with drugs for 6 months. Alprenolol caused mainly a decrease of the estimated endogenous amines in different brain areas. Amphetamine caused a decrease of all three amines in some parts of the brain, and reversed some of the changes caused by alprenolol. Alprenolol had no effect on the locomotor activity of rats, but increased the activity of rats treated with amphetamine after the first week of treatment, and antagonized the excitatory effect caused by amphetamine during the following weeks of the experiment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403997
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  • 5
    Electronic Resource
    Electronic Resource
    Behavioral effects of long-term exposure to magnetic fields in rats (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 14 (1993), S. 287-297 
    Details
    ISSN: 0197-8462
    Keywords: irritability ; open field ; locomotor activity ; static ; extremely low frequency ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Male rats and pregnant and nonpregnant female rats of the Wistar strain were sham-exposed or exposed to static (0.49 T) or to extremely low frequency (50 Hz) magnetic fields (0.018 T) 2 h per day for 20 consecutive days. Measures of irritability, exploratory activity, and locomotion were made in that order before and after the 4th, 10th, and 17th 2-h exposures. A reliable decrease in the irritability of rats after repeated exposure to a static or undulating field was found. No significant effects of treatment conditions on open-field behavior and locomotor activity were observed. Pregnancy had no influence on the behavioral end points. These results indicate that irritability of rats may be used as a simple behavioral indicant of mammalian sensitivity to magnetic fields. © 1993 Wiley-Liss. Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250140402
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    Paper (German National Licenses)
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