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  • 1
    Electronic Resource
    Electronic Resource
    CO-OPERATION BETWEEN ENDOTHELIN AND NITRIC OXIDE IN PROMOTING ENDOTHELIAL CELL MIGRATION AND ANGIOGENESIS (1999)
    Melbourne, Australia : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 26 (1999), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Among the diverse functions of endothelins (ET), their role in the remodelling of blood vessels remains poorly examined. In the present review, we summarize findings obtained in our laboratory and present four independent lines of evidence to support this novel function. We also demonstrate that the motogenic and angiogenic effects of ET are mediated via the ETB receptor and that the functional endothelial nitric oxide synthase (NOS) is requisite for this action.2. We demonstrated that ET stimulates transmigration of endothelial cells in a modified Boyden chamber and accelerates endothelial wound healing acting via ETB receptors.3. In genetically engineered Chinese hamster ovary cells expressing either ETB receptor or endothelial NOS or both, application of ET results in accelerated cell migration only when the receptor and the enzyme are coexpressed. Application of antisense oligonucleotides producing a specific knockdown of the endothelial NOS results in the loss of ET ability to stimulate endothelial cell migration in response to ET.4. Finally, using a novel model of in vivo angiogenesis, we were able to demonstrate that ET enhances formation of new vessels, but this effect requires functional endothelial NOS.5. The described phenomenon of NO production, serving as a prerequisite for endothelial cell locomotion in response to activation of ETB receptor may explain a host of pathophysiological observations on inadequate angiogenesis despite enhanced generation of ET-1.6. Based on the contribution of endothelial cell migration to angiogenesis, these data may implicate insufficient NO production in pathological states (e.g. atherosclerosis, heart failure and hypertension) in the inappropriate response to angiogenic stimuli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1681.1999.03029.x
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  • 2
    Electronic Resource
    Electronic Resource
    ROLE OF MESANGIAL CELLS IN MACULA DENSA TO AFFERENT ARTERIOLE INFORMATION TRANSFER (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 24 (1997), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Extraglomerular mesangial cells are strategically positioned between the macula densa and the afferent arteriole. These cells form a syncytium and are connected with glomerular mesangial cells via gap junctions. The model of immunoablation of mesangial cells in anti-Thy-1 glomerulonephritis carries the promise for understanding the function of mesangial cells as potential transmitters of information between the macula densa and the afferent arteriole.2. The above anatomical relations between structures in the juxtaglomerular apparatus predict several possible routes of information flow. This review charts some hypothetical routes.3. Research into the messenger systems involved in the transfer of signals from the macula densa to mesangial cells and from mesangial cells to the afferent arteriole suggests several candidate molecules to function in this capacity. Mechanisms of action for each candidate are discussed.4. The oscillating nature of the afferent signal and efferent function in the tubuloglomerular feedback system, as well as other discoveries, offer a fertile field for future studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1997.tb01240.x
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  • 3
    Electronic Resource
    Electronic Resource
    Tetrodotoxin-blockable depolarization-activated Na+ currents in a cultured endothelial cell line derived from rat interlobar arter and human umbilical vein (1994)
    Springer
    Pflügers Archiv 428 (1994), S. 91-93 
    Details
    ISSN: 1432-2013
    Keywords: Patch-clamp technique ; Vascular endothelium ; Na channel ; Tetrodotoxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Voltage-dependent Na+ current (INa) was identified in cultured endothelial cells derived from rat interlobar artery (RIAE cells) and human umbilical vein (HUVE cells). Tetrodotoxin (TTX) reduced INa in a dose-dependent manner with the apparent dissociation constant (Kd) of 1.4 μM. Low sensitivity of INa to TTX as well as its kinetics and voltage-dependent properties indicates that voltage-gated Na channels expressed in vascular endothelial cells belong to the so-called TTX-resistant type [2].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374756
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  • 4
    Electronic Resource
    Electronic Resource
    Intermittent trimethoprim-sulfamethoxazole in children with vesicoureteral reflux (1997)
    Springer
    Pediatric nephrology 11 (1997), S. 328-330 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Trimethoprim-sulfamethoxazole ; Prophylaxis ; Urinary tract infection ; Vesicoureteral reflux
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The effectiveness of intermittent low-dose trimethoprim-sulfamethoxazole (TMP-SMZ) for the prophylaxis of recurrent urinary infection is well established in adults. The present study assessed the effectiveness and safety of intermittent low-dose TMP-SMZ in 35 children (24 boys, 11 girls, aged 1 month to 9 years, median age 5 months) with vesicoureteral reflux; 18 children had bilateral reflux. A total of 53 refluxing ureters were graded as I in 2, II in 16, III in 19, IV in 14, and V in 2 cases. The children were given 1 mg/kg body weight of trimethoprim together with 5 mg/kg of sulfamethoxazole at bedtime every other day for 6 – 50 months (mean±SD, 22.9±11.7 months). None of the boys had a recurrence of urinary infection, while 2 of the 11 girls had a total of 7 recurrences during the prophylaxis period, with a recurrence rate of 0.027 per patient month in girls. Both girls were over 3 years and had a mildly unstable bladder. Transient neutropenia (〈1,000/μl) developed in 2 infants during the prophylaxis period, but disappeared spontaneously. Intermittent low-dose TMP-SMZ seemed very effective for the prevention of recurrent urinary infection in children with ureteral reflux even of higher grades.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050287
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  • 5
    Electronic Resource
    Electronic Resource
    Efficacy of long-term azathioprine for relapsing nephrotic syndrome (2000)
    Springer
    Pediatric nephrology 14 (2000), S. 776-778 
    Details
    ISSN: 1432-198X
    Keywords: Key words Nephrotic syndrome (childhood) ; Azathioprine ; Cyclophosphamide ; Frequent relapses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Seven patients who had an initial attack of nephrotic syndrome in childhood and had frequent relapses even after cyclophosphamide therapy were given a 2-year course of azathioprine. The mean annual relapse rates decreased from 2.4±0.5 in the year preceding azathioprine to 0.4±0.8 in the 1st and 2nd years after its initiation. All six patients who were observed for more than 6 months after discontinuation of the therapy were relapse free for this period. Average doses of prednisolone could also be decreased in the 2nd and subsequent years after the therapy. There were no significant toxic effects. Long-term azathioprine therapy may be well tolerated and effective for nephrotic patients with frequent relapses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00013436
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  • 6
    Electronic Resource
    Electronic Resource
    Assessment of tubular function in neonates using urinary β2-microglobulin (1990)
    Springer
    Pediatric nephrology 4 (1990), S. 512-514 
    Details
    ISSN: 1432-198X
    Keywords: Renal proximal tubular function ; Urinary β2-microglobulin ; Preterm neonates ; Meconium aspiration syndrome ; Transient tachypnoea of newborn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Renal proximal tubular function was assessed in neonates by measuring urinary β2-microglobulin (β2M) concentrations on days 1, 4, 7, 14 and 28. Values were elevated in stable preterm low-birthweight (LBW) neonates but not in stable term LBW neonates, suggesting that proximal tubular maturation is related to gestational age rather than birthweight. The urinary β2M was significantly increased on day 1 in neonates with the meconium aspiration syndrome but was not significantly different from normal subsequently. This indicated that although the proximal tubular cells may be susceptible to perinatal hypoxia, they maintain a remarkable capacity to recover in a relatively short period. Neonates with transient tachypnoea of the newborn had normal urinary levels of β2M indicating their renal tubular function was not impaired.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00869835
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  • 7
    Electronic Resource
    Electronic Resource
    Ultrasound findings of ureteral reflux in early infancy (1994)
    Springer
    Pediatric nephrology 8 (1994), S. 264-265 
    Details
    ISSN: 1432-198X
    Keywords: Vesicoureteral reflux ; Ultrasonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00865501
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  • 8
    Electronic Resource
    Electronic Resource
    Haemolytic uraemic syndrome associated withYersinia enterocolitica infection (1988)
    Springer
    Pediatric nephrology 2 (1988), S. 309-311 
    Details
    ISSN: 1432-198X
    Keywords: Haemolytic uraemic syndrome ; Yersinia enterocolitica ; Serum agglutinin titre
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Haemolytic uraemic syndrome (HUS) associated withYersinia enterocolitica gastroenteritis is reported in a 6-year-old girl.Y. enterocolitica of biotype 03 was isolated from the patient's initial stool sample and was subsequently identified as serotype 03 based on the rising agglutinin titres. This paper shows that yersiniosis should be suspected as a possible cause of HUS, and investigations should include the measurement of serum agglutinin titres against antigen preparations of the genusYersinia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00858683
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  • 9
    Electronic Resource
    Electronic Resource
    Urinaryα 1 as an index of proximal tubular function in early infancy (1993)
    Springer
    Pediatric nephrology 7 (1993), S. 199-201 
    Details
    ISSN: 1432-198X
    Keywords: Urinary α1-microglobulin ; Renal proximal tubular function ; Early infancy ; Urinary β2-microglobulin ; Term infants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Urinary α1-microglobulin (U-A1M) was measured in healthy term infants on days 1, 4, 7, 14, 28, 90 and 180 of life. U-A1M was high until day 14 and declined thereafter. It was significantly correlated with urinary β2-microglobulin (U-B2M) throughout the study, but not with serum A1M on days 1 or 7. Similar to U-B2M, U-A1M in the clinically stable term infants with intrauterine growth retardation (n=4–7) was not elevated on days 1–7. In the sick infants who needed immediate resuscitatio at birth (n=4–8), U-A1M as well as U-B2M was high on days 1–7 and then decreased to normal levels, suggesting that U-A1M can be used as a sensitive marker of acute proximal tubular damage and its recovery. These observations indicate that U-A1M is a useful index of proximal tubular function in early infancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00864399
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  • 10
    Electronic Resource
    Electronic Resource
    Clinical course and outcome of idiopathic membranous nephropathy in Japanese children (1993)
    Springer
    Pediatric nephrology 7 (1993), S. 387-391 
    Details
    ISSN: 1432-198X
    Keywords: Idiopathic membranous nephropathy ; Japanese children ; Clinical course and outcome ; Caucasian children ; Steroid therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We retrospectively studied 12 Japanese children (8 boys, 4 girls) with idiopathic membranous nephropathy (IMN), aged 2.9–15.8 (mean 7.7) years at onset. All patients were identified through either screening or a routine urinalysis; proteinuria was present in all, haematuria, which was macroscopic in 4, in 11. Three had nephrotic syndrome (NS) at or soon after onset. Stages on electron microscopy, performed in 10 patients, were I in 3, II in 5 and III in 2. Steroids alone or with cyclophosphamide were administered to 5 patients, including the 3 patients showing NS. Complete remission of proteinuria occurred in 8 patients 0.3–1.6 (mean 0.6) years after onset, and proteinuria did not recur. After a follow-up of 1.6–11.6 (mean 5.9) years, these 8 patients were in complete remission and the remaining 4 had only mild proteinuria; none had hypertension or impaired renal function. Thus, we infer that IMN in Japanese children may have a better course and outcome than IMN in non-Japanese children. Based on a comparative study of Japanese (previously reported cases added to ours) and non-Japanese (mostly Caucasian) children with IMN, this was confirmed: it is possible that steroid therapy in Japanese patients is more effective in inducing remission of NS and preserving renal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00857546
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