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  • 1
    Electronic Resource
    Electronic Resource
    Cryosurgery of lung metastases
    Amsterdam : Elsevier
    Cryobiology 11 (1974), S. 576 
    Details
    ISSN: 0011-2240
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0011-2240(74)90245-4
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  • 2
    Electronic Resource
    Electronic Resource
    Cryosurgery of pulmonary metastases
    Amsterdam : Elsevier
    Cryobiology 16 (1979), S. 171-178 
    Details
    ISSN: 0011-2240
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0011-2240(79)90028-2
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  • 3
    Electronic Resource
    Electronic Resource
    Phagocytosis and biodegradation of short-chain poly [(R)-3-hydroxybutyric acid] particles in macrophage cell line (1995)
    Springer
    Journal of materials science 6 (1995), S. 725-730 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: The biocompatibility and the degradation mechanisms of block co-polyurethanes containing crystallizable telechelic poly [(R)-3-hydroxybutyric acid] (PHB) segments have found recently growing interest for the possible biomedical applications of these new materials. The random hydrolytic cleavage of the amorphous part of these polymers might result, in vivo, in the production of small crystalline particles of low molecular weight PHB that could then undergo phagocytosis and biodegradation inside phagosomes. To test this possibility, a fluorescent-labelled PHB segment was synthesized, precipitated in the form of crystalline particles, and used for an in vitro investigation of its interaction with macrophage cell line. Light and fluorescence microscopy performed in the present study clearly show that the fluorescent particles are well internalized in phagosomes already after 1 h of incubation. The number of phagocytized particles decreases notably after 8 days of incubation. A quantitative determination of the time dependence of the phagocytosis was obtained through laser cytometry and fluorescence-activated cell sorting (FACS). Fluorescence spectroscopy and high-performance liquid chromatography (HPLC) analysis of extracts of cell supernatants revealed the presence of supposed degradation products of PHB after 8 days of incubation, suggesting that macrophages could degrade low molecular weight PHB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00134308
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  • 4
    Electronic Resource
    Electronic Resource
    Multiblock copolyesters as biomaterials: in vitro biocompatibility testing (1997)
    Springer
    Journal of materials science 8 (1997), S. 497-505 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Cell adhesion, cell growth and cell activities of macrophages and fibroblasts, cultured on newly developed degradable multiblock-copolyesters were studied to examine the biocompatibility and the possible use of these polymers for medical applications. The biocompatibility and the biodegradability of the polymers were confirmed by subcutaneous implantation of polymer foils in rats. The newly developed polymers, two polyesters (DegraPol/bsc43 and DegraPol/bsd43) and a polyesterether (DegraPol/bst41), were found to exhibit good cell compatibility; the cell-to-substrate interactions induced neither cytotoxic effects nor activation of macrophages. The adhesion and growth of fibroblasts and macrophages were different among the substrate. Fibroblasts adhered on the polyesters to about 60% of control cell cultured on tissue culture polystyrene (TCPS) and proliferated in the same doubling time as on TCPS. On the polyetherester cells exhibited weak adhesion; however, they proliferated up to day 4 after plating at the same doubling time as on TCPS (of about 42 h), and then decreased their doubling time to 27 h. Macrophages attached to the polyesters to about 40–60% of TCPS but no significant change was seen in the doubling time of cells cultured on TCPS and the polyesters. Again on the polyetherester, macrophages exhibited relatively low adhesion (25% of TCPS) and high doubling time (about 100 h). Fibroblasts produced high amounts (up to 500% of control cells) of collagen type I and type IV, and fibronectin. Macrophages responded to lipopolysaccharide treatment by the production of nitric oxide (NO) and tumour necrosis factor-α (TNF-α), indicating that the cell-to-polymer interactions allow fibroblasts and macrophages to maintain their phenotype. All three test polymers exhibit favourable tissue compatibility. The formed capsule was just a few cell layers thick (〈30 μm). After 2 months implanted subcutaneously in rats, the molecular weight of the test polymers was reduced by 〉20% depending on their chemical structure. Taken collectively, the present data demonstrate that the newly developed multiblock copolyesters are biocompatible and biodegradable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018582311361
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  • 5
    Electronic Resource
    Electronic Resource
    Cell response of cultured macrophages, fibroblasts, and co-cultures of Kupffer cells and hepatocytes to particles of short-chain poly[(R)-3-hydroxybutyric acid] (1996)
    Springer
    Journal of materials science 7 (1996), S. 56-61 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: The known biodegradability of poly[(R)-3-hydroxybutyric acid] (PHB) in certain biological environments has lead to its proposed use as biodegradable, biocompatible polymer. Recently, a new, rapidly biodegradable blockcopolymer has been synthesized that contains crystalline domains of PHB blocks. During degradation of these polymers, the PHB-domains are transformed in a first step into small crystalline particles of short-chain PHB. Therefore, particles of short-chain poly[(R)-3-hydroxybutyric acid] (Mn≈2300) (PHB-P), as possible degradation products, are investigated here for their effects on the viability and activation of macrophages, fibroblasts, and co-cultures of rat Kupffer cells and rat hepatocytes. Results obtained in the present study indicate that phagocytosis of particles of short-chain poly[(R)-3-hydroxybutyric acid] at high concentrations (higher than 10 μg/ml) is dosedependent and associated with cell damage in macrophages but not in fibroblasts. At low concentrations, particles of PHB-P also failed to activate macrophages and are biocompatible. Besides the PHB phagocytosis by Kupffer cells, treatment of co-cultures of Kupffer cells and hepatocytes with 1 μg PHB/ml showed neither cytotoxic (lactate dehydrogenase activity) effects nor any change in albumin secretion by hepatocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00121191
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  • 6
    Electronic Resource
    Electronic Resource
    Fortschritte der Pankreastransplantation beim Menschen (1981)
    Springer
    Langenbeck's archives of surgery 354 (1981), S. 189-194 
    Details
    ISSN: 1435-2451
    Keywords: Pancreatic transplantation ; Renal transplantation ; Juvenile diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zwischen Juli 1980 and März 1981 wurden bei 7 Patienten mit juvenilem Diabetes mellitus and Niereninsuffizienz die Pankreas- und Nierentransplantation durchgeführt. Das Pankreastransplantat wurde nach Verödung des Gangsystems mit Pròlamin intraabdominal plaziert, mit Anastomosierung mit den linken Iliacalgefäßen. Drei Transplantationen waren wegen ungeeigneter Transplantate erfolglos, und ein Pankreas ging an venöser Thrombose verloren. 3 Patienten hingegen sind bei normaler Kost, ohne exogene Insulinzufuhr und trotz Prednisonmedikation bei einer Nachkontrollzeit von maximal 91/2 Monaten normoglykäm.
    Notes: Summary Between July 1980 and March 1981, 7 simultaneous pancreas and kindney transplants were performed in patients with juvenile diabetes and renal insufficiency. A duct-occluded (Prolamine) segmental pancreas was placed into the peritoneal cavity with vascular anastomoses to the left iliac vessels. Three transplantations were unsuccessful because of a damaged transplant, and one was lost because of venous thrombosis. Three patients with a maximal follow-up of 91/2 month have normal blood sugar despite lack of exogenous insulin and despite Prednison intake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01254553
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  • 7
    Electronic Resource
    Electronic Resource
    288. Bronchoplastische Eingriffe (1980)
    Springer
    Langenbeck's archives of surgery 352 (1980), S. 603-603 
    Details
    ISSN: 1435-2451
    Keywords: Bronchoplastic resection ; Benign, malignant tumors ; Bronchoplastische Resektion ; Gutartige, bösartige Bronchustumoren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Auf Grund 14 bronchoplastischer Eingriffe bei gutartigen und 18 bei bösartigen Bronchustumoren werden Indikation (Parenchymerhaltund, ungenügende Lungenfunktion etc.), Symptomatik, Röntgen- und Operationsbefunde, Histologie, Operationstechnik, Letalität (0 bei benignen, 11,3% bei malignen Bronchustumoren) und 5-Jahres-Heilung (100% resp. 20%) dargestellt. Bei günstiger Lokalisation gutartiger Tumoren sind bronchoplastische Verfahren Methode der Wahl, die Letalität null, das Komplikationsrisiko gering. Bei malignen Tumoren ist die Parenchymerhaltung und verbesserte Lebensqualität hervorzuheben.
    Notes: Summary Based on 14 bronchoplastic interventions for benign and 18 for malignant bronchial tumors, indications (parenchyma-saving), borderline respiratory function etc.), symptoms, radiologic and intraoperativefindings, histology, operative technique, mortality (zero in benign, 11.3% in malignant tumors), and 5-year survival (100% respectively 20%) are presented. For benign bronchial tumors with favourable localization bronchoplastic resection is the method of choice, with a very low complication and mortality rate. For malignant tumors, saving of lung parenchyma and improved quality of life are major advantages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292253
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  • 8
    Electronic Resource
    Electronic Resource
    79. Ergebnisse nach Resektion der Trachea (1980)
    Springer
    Langenbeck's archives of surgery 352 (1980), S. 294-294 
    Details
    ISSN: 1435-2451
    Keywords: Trachea resection ; Tumors ; Anastomotic tension ; Material ; Trachearesektion ; Tumoren ; Anastomosenspannung ; Material
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 20 Patienten mit primären (11) oder sekundären (7) Tracheatumoren und 2 benignen Stenosen wurde 3mal cervical, 12mal thorakal, davon 2mal samt Bifurkation eine zirkuläre zweimal eine Wandresektion thorakal vorgenommen. Segmente zwischen 2–9 cm wurden reseziert und alle, außer nach 9 cm End-zu-End anastomosiert. Das Gros der primären Tumoren stellen Cylindrome (6) bei denen das 5-JahresÜberleben 70% ist. Bei den sekundären Tumoren lebt keiner nach 12 Monaten. Die Wichtigkeit der Anastomosenspannung, Vermeidung von nicht resorbierbarem Material und häufigen bronchoskopischen Kontrollen wird betont.
    Notes: Summary In 20 patients with primary (11) or secondary (7) tracheal tumors and 2 benign stenoses, 2–9cm circular resection was performed cervically in 3 cases and thoracically in 12 (bifurcation was included in 2). In all patients except the one with a 9-cm resection, end-to-end anastomosis was used. Resection of the thoracic trachea wall was necessary only twice. Cylindroma (6) represents the majority of primary tumors, with a fiveyear survival rate of 70 %. None of the patients with secondary tumors survived one year. The importance of anastomotic tension, the avoidance of nonresorbable material, and frequent bronchoscopic control is stressed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292040
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  • 9
    Electronic Resource
    Electronic Resource
    Arterienstenosen nach Nierentransplantation (1976)
    Springer
    Langenbeck's archives of surgery 343 (1976), S. 11-21 
    Details
    ISSN: 1435-2451
    Keywords: Kidney transplantation ; Renal artery stenosis ; Renal hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach 268 Nierentransplantationen trat in 7 Fällen eine Transplantatarterienstenose auf. Drei weitere Patienten wurden von einem anderen Zentrum überwiesen. Das Hauptsymptom der Nierenarterienstenose war bei allen 10 Patienten eine innerhalb von 10 Monaten aufgetretene, medikamentös nicht beherrschbare Hypertonie. In 9 Fällen fand sich ein Stenosegeräusch über dem Transplantat. In 6 Fällen war die Hypertonie von einer leichten, auf Abstoßungstherapie nicht ansprechenden Funktionsverschlechterung begleitet. Bestätigt wurde die klinische Verdachtsdiagnose durch eine selektive Transplantatarteriographie. Es ließen sich 2 Haupttypen von Stenosen feststellen: Segmentstenosen, die immer 0,5-2 cm distal der Anastomose auftreten und durch Intimaläsionen anläßlich der Entnahme und Perfusion verursacht werden, und Knickstenosen infolge technisch fehlerhafter Arterienimplantation. Mit einer Ausnahme ließ sich die Hypertonie durch die Gefäßrekonstruktion unter Kontrolle bringen. Jede medikamentös nicht beherrschbare Hypertonie nach Nierentransplantation muß durch eine selektive Transplantatarteriographie abgeklärt werden. Angiographisch nachgewiesene, klinisch manifeste Stenosen sollten operiert werden.
    Notes: Summary After 268 kidney allotransplants, 7 cases of renal artery stenosis were observed. An additional 3 patients were referred to us from another center. The outstanding symptom of all 10 patients was hypertension refractory to medical treatment, beginning not later then 10 months after transplantation. In 9 cases there was a murmur over the transplant. In 6 patients hypertension was accompanied by a deterioration of renal function which was resistant to antirejection therapy. The tentative diagnosis was confirmed by selective renal arteriography of the transplant. Two main types of stenoses could be diagnosed: Segmental stenoses, 0.5–2 cm distal to the anastomosis, which were due to intimal lesions caused during removal of the kidney or by the perfusion canula; and kinking stenoses due to a technically inadequate implantation. Hypertension was controlled in all but 1 patient with reconstruction of the artery. Therefore, hypertension after kidney transplantation refractory to medical treatment should be further investigated with selective renal arteriography of the transplant. Stenoses with clinical symptoms which are confirmed by arteriography should be surgically corrected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01261566
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  • 10
    Electronic Resource
    Electronic Resource
    Die experimentelle Tracheaverlängerung (1972)
    Springer
    Langenbeck's archives of surgery 331 (1972), S. 255-264 
    Details
    ISSN: 1435-2451
    Keywords: Circular Resection ; Anastomosis ; Spiral Incision ; Reduction of Tension ; Fascia Lata
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An Hand experimenteller Untersuchungen an zehn Hunden wird nach Resektion verschieden großer Tracheaabschnitte und direkter End-zu-End-Anastomose die Effektivität der spiralförmigen Tracheaverlängerung untersucht. Es handelt sich um eine ins Dreidimensionale übertragene Z-Plastik, die eine Tracheaverlängerung und damit eine elastische Verminderung der Anastomosenspannung erzielt. Der Vorteil liegt in der direkten End-zu-End-Anastomose und Erhaltung der Flimmerepithelkontinuität. Die Resultate zeigen, daß die Resektion bis zu 13 cm langer Abschnitte der thorakalen Trachea mit erfolgreicher Endzu-End-Anastomose ein verlängertes Überleben (3 Jahre) ohne funktionelle Einschränkung möglich ist. Die Anwendbarkeit, technische Vereinfachungen und Kombination mit anderen Verlängerungs- oder Rekonstruktionsmaßnahmen werden diskutiert.
    Notes: Summary Basing on 10 canine experiments, the efficiency of the spiral elongation of the thoracic trachea after resection of varying tracheal segments and primary end-to-end anastomosis are examined. The pricipale of the spiral elongation plasty is that of a z-plasty transformed into the third dimension. This achieves both elongation of the trachea and reduction of the anastomotic tension. The advantage lies in the direct end-to-end anastomosis and preservation of the epithelial continuity of the trachea. Long time survival up to three years was found after resection of segments up to 13 cm without functional deterioration. Technique, postoperative cours and x-ray examination are presented. Applicablity, technical improvements and combination with other elongation or reconstructive methods are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01232231
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