ISSN:
1573-8221
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Albino rats ranging in weight from 180 to 200 g were given dicoumarin per os. The first group of animals were given a single 5 mg dose of the preparation shortly before the experiment. To rats of the second group dicoumarin was administered during three days: a 5 mg dose on the first day, and a 2 mg dose on the second and third day before the experiment. On the day of the experiment the rats were given thrombin intravenously; the fibrinogen content of the blood was examined before and six minutes after the injection, as well as changes in the following tests were studied: total time of coagulation, prothrombin time, thrombin time, and the time of thromboplastin generation. It was found that within the first 24 h of administration of a single dicoumarin dose the intravenous injection of thrombin caused in the test animals a larger decline of fibrinogen concentration than in the control animals. The animals given dicoumarin during three days reacted to intravenous thrombin injection in the same way as the control rats.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00792429
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