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  • 1
    Electronic Resource
    Electronic Resource
    Goserelin a GnRH-analogue as third-line therapy of refractory epithelial ovarian cancer (1992)
    Three Cambridge Center,Suite 208, Cambridge, MA 02142, USA : Blackwell Scientific Publications
    International journal of gynecological cancer 2 (1992), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Between October 1988 and March 1991, 23 ovarian cancer patients with progressive disease whilst receiving second- or third-line polychemotherapy received subcutaneously 3.6 mg Goserelin, a GnRH analogue, at monthly intervals until further tumor progression. Four patients (17.4%) achieved partial response, 7 patients (30.4%) had stable disease and 12 patients (52.2%) showed further tumor progression. Median time to tumor progression was 8.5, 5.3 and 2.1 months, respectively (Mantel test, P = 0.0003). Ten out of 11 patients who showed partial response or no change had grade 2 or grade 3 tumors. We conclude that Goserelin shows evidence of antitumor activity also in grade 2 and grade 3 ovarian carcinoma. It offers a therapeutic alternative to a group of patients, in whom we usually terminate cytotoxic treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1992.02030160.x
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  • 2
    Electronic Resource
    Electronic Resource
    Ergebnisse der elektrochirurgischen Vulvektomie mit postoperativer Bestrahlung der Inguinallymphknoten beim Vulvakarzinom (1989)
    Springer
    Archives of gynecology and obstetrics 245 (1989), S. 525-528 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Behandlungsergebnisse von 669 eigenen Patientinnen mit invasivem Plattenepithelkarzinom der Vulva, die zwischen 1952 und 1982 behandelt wurden, werden dargestellt und analysiert. Die absolute 5-Jahres-Heilung betrug in diesem Patientinnengut 62%. Bei Bereinigung der interkurrent verstorbenen und verschollenen Patientinnen steigt das Behandlungsergebnis auf 70%. Alle Patientinnen wurden einheitlich mittels elektrochirurgischer Radikaloperation und postaktinischer Bestrahlung der Inguinallymphknoten behandelt.
    Notes: Summary Clinical data on 669 patients with in vasive squamous cell carcinoma of the vulva were seen between 1952 and 1982. All of these patients were available for 5-year evaluation. The crude survival for these patients was 62%, and the “cleaned” 5-year survival for 585 patients was 70%. All patients were treated with radical vulvectomy using the warm knife and open-wound technique. Treatment of the regional lymph nodes was performed by irradiation alone. This simple surgical technique in combination with radiotherapy applied only to the inguinal lymph nodes gives an excellent result without the complications associated with aggressive surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02417405
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  • 3
    Electronic Resource
    Electronic Resource
    Primary Fallopian tube carcinoma – a retrospective survey of 51 cases (1994)
    Springer
    Archives of gynecology and obstetrics 255 (1994), S. 141-146 
    Details
    ISSN: 1432-0711
    Keywords: Key words: Fallopian tube carcinoma – Stage 0 – Stage I – Chemotherapy – Irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: To evaluate retrospectively the importance of invasion beyond the basement membrane on overall survival in Fallopian tube carcinoma and its influence on the necessity of postoperative adjuvant therapy (stage 0 vs. stage I). Design: In a nationwide analysis the data of 51 patients were evaluated. The participating departments provided the study center with histologic specimens. A re-staging was done according to the FIGO-classification for Fallopian tube carcinomas. Stage 0 patients received no further postoperative therapy, in stage I patients were devided in 2 groups to evaluate the impact of postoperative adjuvant therapy (chemotherapy vs. irradiation). Results: Patients of stage 0 had a significantly better prognosis than patients of stage I (p=0.035). Stage I patients treated by irradiation showed a significantly better prognosis than patients treated by chemotherapy (p=0.017). Conclusion: Tumour penetration through the basement membrane causes prognosis to deteriorate significantly (5-year survival rate about 50% in stage I). Postoperative therapy is thus indicated with stage I disease. Irradiation seems to give better results than chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004040050042
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  • 4
    Electronic Resource
    Electronic Resource
    Evaluation of adjuvant therapy after surgery for primary carcinoma of the Fallopian tube (1994)
    Springer
    Archives of gynecology and obstetrics 255 (1994), S. 19-24 
    Details
    ISSN: 1432-0711
    Keywords: Primary carcinoma of the Fallopian tube ; Adjuvant therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To evaluate the impact of postoperative therapy (chemotherapy vs. irradiation) on overall survival.Design: A nationwide retrospective analysis.Setting: Hanusch-Krankenhaus, Department of Gynaecology.Subjects: 115 patients with histologically proved primary carcinoma of the Fallopian tube: 49 received six treatment cycles of a cis-platinum regimen (group I), 24 patients were treated by full irradiation using 50 Gray minimum (group II). The two groups had a similar distribution of stage I and II; in the more advanced stages chemotherapy was the predominant method of treatment.Results: The five-year survival rate was 53% for women receiving irradiation as against 27% for those given cis-platinum. If the analysis was restricted to those patients with comparable stage I and stage II lesions, the p-value (0.07) was of borderline significance. There was no advantage in adding abdominal to pelvic irradiation (P=0.62).Conclusions: Stage I and stage II carcinoma is probably better treated postoperatively by radiotherapy than chemotherapy. Chemotherapy may have more therapeutic potential in patients with more advanced lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02390670
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  • 5
    Electronic Resource
    Electronic Resource
    Evaluation of adjuvant therapy after surgery for primary carcinoma of the Fallopian tube (1994)
    Springer
    Archives of gynecology and obstetrics 255 (1994), S. 19-24 
    Details
    ISSN: 1432-0711
    Keywords: Key words: Primary carcinoma of the Fallopian tube – Adjuvant therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: To evaluate the impact of postoperative therapy (chemotherapy vs. irradiation) on overall survival. Design: A nationwide retrospective analysis. Setting: Hanusch-Krankenhaus, Department of Gynaecology. Subjects: 115 patients with histologically proved primary carcinoma of the Fallopian tube: 49 received six treatment cycles of a cis-platinum regimen (group I), 24 patients were treated by full irradiation using 50 Gray minimum (group II). The two groups had a similar distribution of stage I and II; in the more advanced stages chemotherapy was the predominant method of treatment. Results: The five-year survival rate was 53% for women receiving irradiation as against 27% for those given cis-platinum. If the analysis was restricted to those patients with comparable stage I and stage II lesions, the p-value (0.07) was of borderline significance. There was no advantage in adding abdominal to pelvic irradiation (P=0.62). Conclusions: Stage I and stage II carcinoma is probably better treated postoperatively by radiotherapy than chemotherapy. Chemotherapy may have more therapeutic potential in patients with more advanced lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004040050020
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  • 6
    Electronic Resource
    Electronic Resource
    Preoperative and postoperative CA-125 serum levels in primary Fallopian tube carcinoma (1994)
    Springer
    Archives of gynecology and obstetrics 255 (1994), S. 65-68 
    Details
    ISSN: 1432-0711
    Keywords: Key words: Fallopian tube carcinoma – CA-125 serum levels – Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Levels of CA-125 were determined pre- and postoperatively in 13 patients with Fallopian tube cancer. Values before surgery were significantly higher (Median 1220 IU/ml, 90 – 5000 IU/ml) compared with postoperative levels (Median 194 IU/ml, 67 – 880 IU/ml) (P=0.0052). Correlation analysis with FIGO stage and grading failed to show any statistical significance, but a trend for a positive correlation with FIGO stage and preoperative values could be observed. The CA-125 antigen is expressed by Fallopian tube carcinoma and should therefore be used in diagnosis and follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004040050029
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  • 7
    Electronic Resource
    Electronic Resource
    Preoperative and postoperative CA-125 serum levels in primary Fallopian tube carcinoma (1994)
    Springer
    Archives of gynecology and obstetrics 255 (1994), S. 65-68 
    Details
    ISSN: 1432-0711
    Keywords: Fallopian tube carcinoma ; CA-125 serum levels ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Levels of CA-125 were determined pre- and postoperatively in 13 patients with Fallopian tube cancer. Values before surgery were significantly higher (Median 1220 IU/ml, 90–5000 IU/ml) compared with postoperative levels (Median 194 IU/ml, 67–880 IU/ml) (P=0.0052). Correlation analysis with FIGO stage and grading failed to show any statistical significance, but a trend for a positive correlation with FIGO stage and preoperative values could be observed. The CA-125 antigen is expressed by Fallopian tube carcinoma and should therefore be used in diagnosis and follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02391799
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  • 8
    Electronic Resource
    Electronic Resource
    Primary Fallopian tube carcinoma — a retrospective survey of 51 cases (1994)
    Springer
    Archives of gynecology and obstetrics 255 (1994), S. 141-146 
    Details
    ISSN: 1432-0711
    Keywords: Fallopian tube carcinoma ; Stage 0 ; Stage I ; Chemotherapy ; Irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To evaluate retrospectively the importance of invasion beyond the basement membrane on overall survival in Fallopian tube carcinoma and its influence on the necessity of postoperative adjuvant therapy (stage 0 vs. stage I).Design: In a nationwide analysis the data of 51 patients were evaluated. The participating departments provided the study center with histologic specimens. A re-staging was done according to the FIGO-classification for Fallopian tube carcinomas. Stage 0 patients received no further postoperative therapy, in stage I patients were devided in 2 groups to evaluate the impact of postoperative adjuvant therapy (chemotherapy vs. irradiation).Results: Patients of stage 0 had a significantly better prognosis than patients of stage I (p=0.035). Stage I patients treated by irradiation showed a significantly better prognosis than patients treated by chemotherapy (p=0.017).Conclusion: Tumour penetration through the basement membrane causes prognosis to deteriorate significantly (5-year survival rate about 50% in stage I). Postoperative therapy is thus indicated with stage I disease. Irradiation seems to give better results than chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02390941
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  • 9
    Electronic Resource
    Electronic Resource
    Reproductive performance after local and systemic prostaglandin for ectopic pregnancy (1992)
    Springer
    Archives of gynecology and obstetrics 252 (1992), S. 45-48 
    Details
    ISSN: 1432-0711
    Keywords: Tubal pregnancy ; Prostaglandin treatment ; Reproductive performance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The injection of different substances into early, unruptured tubal pregnancies is increasingly advocated. In this study, fertility was evaluated after treatment of tubal pregnancy by means of prostaglandins. The overall tubal patency rate was 86.4% and 14 of 20 patients (70%) could subsequently achieve pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02389606
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  • 10
    Electronic Resource
    Electronic Resource
    Die direkte Umsetzung von Phenolen mit Dimethylsulfoxid Methylthiomethylierung von Anilinen und Phenolen, 6. Mitt. (1971)
    Springer
    Monatshefte für Chemie 102 (1971), S. 1072-1080 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Es wird gezeigt, daß Phenole durch Umsetzung mitDMSO bei dessen Siedetemperatur auch ohne Zusatz aktivierender Stoffe methylthiomethyliert werden. Es tritt auch unter diesen Bedingungen stark bevorzugt Methylthiomethylierung am o-C-Atom zur phenolischen Hydroxylgruppe ein. Es wird angenommen, daß auch hier der für Methylthiomethylierungen von Phenolen und Anilinen mit “aktiviertem”DMSO vorgeschlagene Mechanismus wirksam ist. Verglichen mit bisher bekannten Methoden, tritt unter den Bedingungen der direkten Umsetzung eine verstärkte Bildung von Phenyl-methylthiomethyläthern ein, die allerdings bei den gegebenen Reaktionsbedingungen allmählich wieder zersetzt werden.
    Notes: Abstract It is demonstrated that phenols are methylthiomethylated by mere refluxing inDMSO. Also under these conditions methylthiomethylation occurs preferably in o-positions to the phenolic hydroxyl group. It is assumed that a similar mechanism is valid as proposed for methylthiomethylation of phenols and anilines with “activated”DMSO. Compared with other methods known as yet, higher amounts of phenyl methylthiomethyl ethers are formed but slowly decomposed under the given conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00909933
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