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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of basement membrane type VII collagen and laminin in neoplasms of the head and neck (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 21 (1992), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The distribution pattern of the basement membrane components type VII collagen and laminin, was studied immunohistochemically in normal human head and neck tissues and in a series of benign and malignant tumours from the same site. Using monoclonal antibodies, a basement membrane containing type VII collagen and laminin could be demonstrated beneath the epithelial cell layer in 16 normal head and neck tissues from different localizations. Unlike type VII collagen, laminin was also abundantly present around blood vessels and muscle fibres.With respect to 42 squamous cell carcinomas studied, type VII collagen and laminin were present in basement membranes surrounding small and large tumour fields, independent of the tumour grade. Type VII collagen was demonstrated in the cytoplasm of tumour cells in 36% of the cases, while the antibody to laminin displayed a basement membrane staining pattern mainly. Both antibodies showed a staining gradient in more than half of the cases, with strong staining in the centre of the tumour and weakening of the staining towards the tumour periphery.In a series of 22 salivary gland tumours consisting of 19 pleomorphic adenomas and three adenoid cystic carcinomas, the distribution pattern of type VII collagen and laminin was very heterogeneous. Laminin was present in 17 and type VII collagen in 10 of 19 cases of pleomorphic adenoma, mostly scattered throughout the tumour fields. In the tumours positive for type VII collagen areas with little or no positivity were also found. A correlation between type VII collagen positivity and the presence of basal cell keratin 14 positivity was noticed in the majority of cases. The three adenoid cystic carcinomas studied displayed random positivity with the laminin antibody, whilst the antibody to type VII collagen showed little positivity in these cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1992.tb00431.x
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  • 2
    Electronic Resource
    Electronic Resource
    The centre-to-limb variation of the moon's brightness at 2 and 6cm wavelength (1977)
    Springer
    Earth, moon and planets 17 (1977), S. 395-400 
    Details
    ISSN: 1573-0794
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A map of the Moon at 2 cm wavelength is presented. The angular (≃ 1′arc) and temperature resolution (〈 0.1 K) is sufficient to study systematic details of the brightness distribution. In particular, the centre-to-limb variation is considered. An estimate of the dielectric constant∈ is possible (1.4 ⩽∈ ⩽ 2.5). The existence of a temperature gradient in the lunar surface layers is used to derive the depth of penetration of electromagnetic waves (L e ), which isL e ≃ 8 m for 2 cm wavelength. The parameters derived from the 2 cm map are found to be compatible with those obtained from a former observation at 6 cm wavelength.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562648
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Expression of intermediate filament proteins in benign lesions of the oral mucosa (1999)
    Springer
    European archives of oto-rhino-laryngology and head & neck 256 (1999), S. 514-519 
    Details
    ISSN: 1434-4726
    Keywords: Key words Cytokeratin ; Vimentin ; Mucosa ; Benign oral cavity ; Lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunohistochemistry with monospecific antibodies was used to study the expression patterns of cytokeratins (Cks) and vimentin in non-dysplastic lesions of the oral cavity, including lichen planus and fibromas. In hyperplastic lesions, Ck expression did not deviate significantly from the normal non-keratinizing squamous epithelium of the oral cavity. Hyperkeratotic lesions showed pronounced aberrations in their Ck profile. These lesions were characterized by extended expression of the keratinization marker Ck 10, the basal cell Ck 14 and the hyperproliferation-associated Ck 16 in the suprabasal compartment. The stratification markers Cks 4 and 13 showed a decreased expression. Coexpression of Cks and vimentin was found in lesions having accumulations of inflammatory cells in the subepithelial cell layer. These changes are felt to characterize benign mucosal lesions without dysplasia and might be helpful for distinguishing these lesions from potentially malignant ones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050202
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  • 4
    Electronic Resource
    Electronic Resource
    Accuracy of two enzyme immunoassays and cell culture in the detection ofChlamydia trachomatis in low and high risk populations in senegal (1992)
    Springer
    European journal of clinical microbiology & infectious diseases 11 (1992), S. 527-534 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two enzyme immunoassays (EIAs), Chlamydiazyme (CZ; Abbott Laboratories) and Pathfinder (PF; Kallestadt), were compared with a cell culture technique in the detection of cervicalChlamydia trachomatis infection in 670 women in urban settings in Senegal (377 pregnant women and 293 prostitutes). Positive CZ and positive PF specimens were tested a second time using a monoclonal antibody blocking technique. True positive specimens were defined as those positive on culture or positive on EIA with confirmation of the result after blocking. Using this definition, the prevalence of genital chlamydial infection was 14.6 % and 14.3 % in pregnant women and prostitutes respectively. An important difference between the two populations was that the pregnant women were younger than the prostitutes, which might explain the fact that the prevalence of infection among the pregnant women was as high as that among the prostitutes, although the age-adjusted prevalence was higher among prostitutes than among pregnant women. The chlamydial detection rates of cell culture, CZ and PF were 62 % (26/42), 69 % (29/42) and 86 % (36/42) respectively in prostitutes and 76 % (42/55), 40 % (22/55) and 53 % (29/55) respectively in pregnant women. Agreement between the tests was 89 %, 85 % and 88 % for culture/CZ, culture/PF and CZ/PF respectively. However, when data were adjusted for chance agreement, kappa coefficients were 0.40 for culture/CZ, 0.34 for culture/PF and 0.48 for CZ/PF. These results indicate that the accuracy of the EIAs and cell culture may vary greatly in different populations: both EIAs showed a distinctly higher detection rate than culture in prostitutes and a significantly lower detection rate in pregnant women. Confirmation of positive EIA results with a blocking assay greatly enhanced the specificity of the antigen detection tests and should be obtained when using the EIAs in a clinical setting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01960808
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  • 5
    Electronic Resource
    Electronic Resource
    Cytokeratin and vimentin expression in normal epithelium and squamous cell carcinomas of the larynx (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 376-383 
    Details
    ISSN: 1434-4726
    Keywords: Larynx ; Squamous cell carcinoma ; Metastases ; Tumor markers ; Cytokeratins ; Vimentin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The immunohistochemical expression patterns of cytokeratin polypeptides and vimentin were investigated in normal epithelia and squamous cell carcinomas of the larynx with special emphasis on tumor grading. During malignant transformation of epithelial cells, the cytokeratin expresssion patterns changed, depending on the differentiation grade of the carcinomas. In low-grade carcinomas, the expression patterns were close to those of the normal epithelium. With increasing tumor grade, there was decreased expression of stratification cytokeratins and increased expression of basal cell, simple cell and hyperproliferation-related cytokeratins. Increasing tumor grade was also associated with the expression of vimentin, a cytoskeletal protein of mesenchymal cells. No relationship was found between vimentin expression and the presence of lymph-node metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01642554
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