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  • 1
    Electronic Resource
    Electronic Resource
    Binding domains and epitopes in platelet-derived growth factor (1989)
    s.l. : American Chemical Society
    Biochemistry 28 (1989), S. 2961-2966 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00433a033
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  • 2
    Electronic Resource
    Electronic Resource
    Ternary Polymer Mixtures (1977)
    s.l. : American Chemical Society
    Macromolecules 10 (1977), S. 157-160 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma60055a032
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  • 3
    Electronic Resource
    Electronic Resource
    Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study (1999)
    Springer
    Diabetologia 42 (1999), S. 113-116 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Intramyocellular lipids ; insulin sensitivity ; NMR spectroscopy ; skeletal muscle ; triglycerides.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent muscle biopsy studies have shown a relation between intramuscular lipid content and insulin resistance. The aim of this study was to test this relation in humans by using a novel proton nuclear magnetic resonance (1H NMR) spectroscopy technique, which enables non-invasive and rapid ( ∼ 45 min) determination of intramyocellular lipid (IMCL) content. Normal weight non-diabetic adults (n = 23, age 29 ± 2 years, BMI = 24.1 ± 0.5 kg/m2) were studied using cross-sectional analysis. Insulin sensitivity was assessed by a 2-h hyperinsulinaemic ( ∼ 450 pmol/l)-euglycaemic ( ∼ 5 mmol/l) clamp test. Intramyocellular lipid concentrations were determined by using localized 1H NMR spectroscopy of soleus muscle. Simple linear regression analysis showed an inverse correlation (r = –0.692, p = 0.0017) between intramyocellular lipid content and M-value (100–120 min of clamp) as well as between fasting plasma non-esterified fatty acid concentration and M-value (r = –0.54, p= 0.0267). Intramyocellular lipid content was not related to BMI, age and fasting plasma concentrations of triglycerides, non-esterified fatty acids, glucose or insulin. These results show that intramyocellular lipid concentration, as assessed non invasively by localized 1H NMR spectroscopy, is a good indicator of whole body insulin sensitivity in non-diabetic, non-obese humans. [Diabetologia (1999) 42: 113–116]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051123
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  • 4
    Electronic Resource
    Electronic Resource
    Zur Früherkennung der diabetischen Nephropathie: Beta2-Mikroglobulin im Serum (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 1209-1215 
    Details
    ISSN: 1432-1440
    Keywords: Diabetes mellitus ; Nephropathy ; Serum beta2-microglobulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Detection of early diabetic nephropathy is necessary to postpone or even prevent progression of irreversible kidney damage by therapeutic measures. Beta2-microglobulin (β2-MG) as a parameter of the glomerular filtration rate has been measured by immunoassay in the serum of 100 diabetic subjects, 50 insulin-dependent (IDD), and 50 noninsulin-dependent (NIDD) patients. The results are compared with endogenous creatinine-clearance, serum creatinine concentration, and proteinuria and are related to different stages of diabetic retinopathy (RD). Normal values were obtained from 50 healthy age- and sex-matched subjects. A close correlation was found between β2-MG levels and endogenous creatinine clearance. Thirty-nine diabetics revealed an elevated β2-MG (2.5 mg/l or higher), only 16 of whom had increased serum creatinine levels (1.4 mg/dl or higher). Significant differences of β2-MG were obtained between each group of patients with different stages of RD. A relevant difference of serum creatinine was found only between patients with normal eye fundus and advanced proliferative retinopathy, respectively. Without RD 26% of the patients revealed elevated β2-MG but normal creatinine values demonstrating a “latent nephropathy”, just 8% showed an increase of both parameters. Of the diabetics with proliferative retinopathy 40% suffered from impaired kidney function proven by reduced creatinine clearance and by elevation of β2-MG and creatinine as well, 15% just revealed an increase of β2-MG with normal creatinine levels. The incidence and extent of nephropathy demonstrated by pathologic values of both β2-MG and serum creatinine were significantly higher in IDD patients with a smaller proportion of “latent nephropathy” as compared to NIDD patients (p〈0.02). This is also true for the markedly increased proteinuria in IDD subjects. In both groups, measurement of β2-MG disclosed more often decrease of renal function in diabetics than did concentrations of serum creatinine. The determination of serum β2-MG appears to be a reliable and sensitive method for the early detection of minor impairment of kidney function in diabetes mellitus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537432
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  • 5
    Electronic Resource
    Electronic Resource
    The importance of visual arts in the life of a neurosurgeon (1993)
    Springer
    Acta neurochirurgica 124 (1993), S. 168-171 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401143
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  • 6
    Electronic Resource
    Electronic Resource
    Different release of cytokines into the cerebrospinal fluid following surgery for intra- and extra-axial brain tumours (1997)
    Springer
    Acta neurochirurgica 139 (1997), S. 619-624 
    Details
    ISSN: 0942-0940
    Keywords: Cytokines ; brain tumours ; neurosurgery ; cerebrospinal fluid ; brain injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the role of cytokines in brain repair processes and in local inflammation after neurosurgical procedures, cerebrospinal fluid (CSF) samples from 8 patients with intra-axial tumours and 8 patients with extra-axial tumours were analysed for interleukin (IL)-1beta, IL-1 receptor antagonist (IL-1ra), IL-6, IL-8, IL-10, and tumour necrosis factor (TNF)-alpha at the beginning and after surgery. Levels of IL-6 and IL-8 increased dramatically in all patients just hours after surgery and fell during subsequent days. IL-1beta was found only in low amounts in the CSF of both patient groups. Other cytokines demonstrated different courses. In patients with intra-axial tumours IL-1ra peaked two to four hours after surgery with a subsequent decrease. In patients with extra-axial tumours there was a continuous low-level IL-1ra release into the CSF without a peak. TNF-alpha was not present in detectable levels in the CSF after surgery for extra-axial tumours but was found to peak two to four hours after surgery for intra-axial tumours. IL-10 was detected in the CSF of both patient groups, but a higher peak was seen after surgery for extra-axial tumours. These results suggest different requirements for the cytokine response and an involvement of different cell types in cytokine release. However, the analysis of the CSF from both patient groups showed no differences in cell counts and populations, with a mild pleocytosis being present in both patient groups after surgery. Therefore, we conclude that after surgery for extra-axial tumours cytokines were predominately produced by non-immune cells stimulated through hypoxia or mechanical irritation. After surgery for intra-axial tumours with a significant brain injury immune cells — activated by necrotic material —seem to be involved in the process of cytokine synthesis. In these cases an additional IL-1ra and TNF-alpha peak was found and these cytokines may be markers for cerebral injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411996
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  • 7
    Electronic Resource
    Electronic Resource
    Computer-Aided Investigation of Isothermal Grain Growth in Copper and Brass (1996)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 204-206 (Mar. 1996), p. 449-454 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/01/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.204-206.449.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Cloned fragments of human adenovirus type-12 DNA
    Amsterdam : Elsevier
    Gene 15 (1981), S. 273-278 
    Details
    ISSN: 0378-1119
    Keywords: BamHI ; EcoRI ; HinIII ; PstI fragments ; Recombinant DNA ; pBR322 ; pBR325 ; removal of terminal protein ; λgtWES . λB' vectors)
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(81)90136-0
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  • 9
    Electronic Resource
    Electronic Resource
    Elastic mechanisms in animal movement - R. McNeill Alexander. Cambridge University Press, 1988. 34.50 (cloth), 141 pp
    Amsterdam : Elsevier
    Bulletin of Mathematical Biology 52 (1990), S. 329-330 
    Details
    ISSN: 0092-8240
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0092-8240(90)90018-7
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Bulletin of Mathematical Biology 52 (1990), S. 329-330 
    Details
    ISSN: 0092-8240
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0092-8240(05)80018-7
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