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  • 1
    Electronic Resource
    Electronic Resource
    Coin lesions in patients returning from countries with a different climate (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 391-391 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235518
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Precipitins to inhaled avian antigens: Results of an inter-laboratory study (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 13 (1983), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Precipitins against avian antigens in sera from patients with extrinsic allergic alveolitis, asymptomatic pigeon and chicken breeders and from control individuals were tested with different antigen extracts in six laboratories by a variety of different methods. Eighty percent of the results coincided in identifying the positive sera from patients and 90% in identifying the controls. It seems possible therefore to exchange results among experienced laboratories with fair confidence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1983.tb02621.x
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  • 3
    Electronic Resource
    Electronic Resource
    Incorporation of radioactive labelled cholin and palmitate into lung lecithin of rabbits treated with high doses of bromcarbamides, barbiturates and diazepam (1977)
    Springer
    Archives of toxicology 37 (1977), S. 117-122 
    Details
    ISSN: 1432-0738
    Keywords: Bromcarbamides ; Barbiturates ; Diazepam ; Lung metabolism ; Phospholipids ; Surfactant system ; Respiratory distress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Schwere, meist suicidale, Intoxikationen mit Bromcarbamiden zeigen häufig respiratorische Komplikationen. Zur Beantwortung der Frage, ob die Pharmaka einen direkten Effekt auf das Lungengewebe ausüben, untersuchten wir die Inkorporation radioaktiv markierten Cholins und radioaktiv markierter Palmitinsäure ins Lungenlecithin. Der Phospholipidmetabolismus steht in enger Relation zum Surfactant-System der Lunge. Außerdem verglichen wir den Einfluß vom Bromcarbamiden mit anderen Sedativa. Bei allen mit Pharmaka behandelten Tieren war eine Reduktion der Palmitatinkorporation z. T. bis auf 40% zu verzeichnen, während die Inkorporation von Cholin unter Bromcarbamiden sogar zunahm. Das zahlenmäßige Verhältnis zwischen Palmitat- und Cholininkorporation war in der Kontrollgruppe 6.77 und nahm auf 2–3 in der Bromcarbamidgruppe ab. Der Gesamtphospholipidgehalt der Lunge/g Feuchtgewicht blieb während der Experimente unverändert. Aus diesen Untersuchungen wird geschlossen, daß Sedativa, aber besonders Bromcarbamide, den Fettsäureaustausch am Lecithinmolekül der Lunge vermindern. Dieses könnte zu einer Bildung nicht oberflächenaktiven Lecithins fuhren. Die klinischen und morphologischen Aspekte der schweren Bromcarbamidintoxikation sind vereinbar mit einer Störung der Oberflächenfunktion in der Lunge.
    Notes: Abstract Severe intoxications with bromcarbamides often show respiratory complications. To answer the question if there is a direct effect of the drug on lung tissue we investigated the incorporation of radioactive labelled choline and palmitate into lung lecithin. The phospholipid metabolism is in close relation to the surfactant system of the lung. Secondly we compared the influence of bromcarbamides with other hypnotic drugs. In all animals of our experiments there was a reduction of palmitate incorporation into lung lecithin down to 40%, whereas the incorporation of choline increases in bromcarbamide-intoxication. The relation between palmitate and choline incorporation was 6.77 in the controls and it decreases to 2–3 in the bromcarbamide group. The total phospholipid content in the lung/g wet weight remained unchanged in all experiments. From this data we conclude, that under these drugs, most pronounced under bromcarbamides, there is a reduction of fatty acid exchange of the lecithin molecules of the lung. This might lead to the production of non surface active lecithin. The clinical and the morphological aspects of severe bromcarbamide intoxication are consistent with a perturbation of the surfactant function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293861
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Zentrale pontine Myelinolyse nach ausgeprägter Hyponatriämie (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 191-198 
    Details
    ISSN: 1432-1440
    Keywords: Hyponatremia ; Pontine myelinolysis ; Alcoholism ; Sodium substitution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Central pontine myelinolysis is a process of demyelinisation with variable neurological symptoms related to the localization. Predisposing factors are alcoholism and malnutrition. Rapid correction of severe hyponatremia is suspected to be a primary cause for central pontine myelinolysis. We report a 43 year old chronic alcoholic and polytoxicomanic female patient, who was admitted comatose with a serum sodium level of 94 mmol/l, caused by a syndrome of inappropriate ADH secretion. After initial improvement under careful sodium correction, the patients neurologic condition degraded progressively and within 4 weeks she developed a “locked-in”-syndrome. Only then the suspected central pontine myelinolysis could be demonstrated in nuclear magnetic resonance and computer tomography. We presume that, although sodium correction was done relatively slowly in this patient, it probably contributed to her development of central pontine myelinolysis all the same. Due to this case we review the literature on correction of hyponatremia, which shows growing evidence that it should start early but be continued very slowly (rise in serum-Na: max. 0,6 mmol/l/h) and requires frequent laboratory controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01649086
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  • 5
    Electronic Resource
    Electronic Resource
    Lipoprotein (a), low-density, intermediate-density lipoprotein, and blood pressure in a young male population (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 145-149 
    Details
    ISSN: 1432-1440
    Keywords: Lipoprotein (a) ; Intermediate-density lipoprotein ; Low-density lipoprotein ; Hypertension ; Body weight
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Both hypercholesterolemia and hypertension are risk factors for atherosclerotic vascular disease, and elevated cholesterol levels occur more frequently than expected in patients with hypertension. Elevated levels of intermediate-density lipoproteins (IDL) and low-density lipoproteins (LDL) were shown to be atherogenic, and LDL, comprising the major cholesterol-carrying fraction in human plasma, are structurally related to lipoprotein (a) [Lp(a)], a further risk factor for atherosclerosis. In the present study we investigated 200 male employees (mean age 26±7 years) to determine whether the relationship of IDL and Lp(a) to systemic blood pressure is similar to the reported correlations between total and LDL cholesterol and systemic blood pressure. To this end blood pressure was measured several times in each individual, and lipids, lipoprotein-cholesterol, apolipoprotein B (apo B), and Lp(a) were determined in fasting serum. IDL cholesterol and apo B, the main protein component of IDL and LDL correlated with blood pressure. However, levels of Lp(a) correlated neither with systolic or diastolic blood pressure nor with lipoprotein cholesterol, body weight, or age. Although IDL and Lp(a) are considered lipoprotein risk factors for atherosclerosis, levels of Lp(a), unlike IDL, are not related to blood pressure, body weight, or age. Our data suggest different metabolic and pathophysiological mechanisms of the risk factors, IDL, LDL, and Lp(a).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179996
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  • 6
    Electronic Resource
    Electronic Resource
    Die sogenannte Schocklunge, ein Krankheitsbild des Lungenparenchyms (1977)
    Springer
    Langenbeck's archives of surgery 344 (1977), S. 157-169 
    Details
    ISSN: 1435-2451
    Keywords: Shock lung ; ARDS (Adult respiratory distress syndrome) ; Respiratory insufficiency ; Lung parenchyma ; Lung diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die sog. Schocklunge ist ein aus klinischer Sicht einheitliches Syndrom, obwohl die Pathogenese unterschiedlich sein kann. Ausgehend von morphologischen Befunden werden Überlegungen zur Pathogenese und zum Ablauf der Veränderungen in der Lunge angestellt. Funktionsstörungen der Mikrozirkulation, Veränderungen der Gefäßpermeabilität und des surfactant-Systems der Lunge sind in der Pathogenese der sog. Schocklunge wesentliche Faktoren. Unabhängig von der Art der besonderen Pathogenese im Einzelfall ist der Ablauf der Veränderungen im Lungenparenchym uniform. Pathologische Anatomie und Funktionsstörung stimmen modellhaft überein. Die Beziehung der Schocklunge zu anderen Lungenparenchymerkrankungen wird erörtert und anschließend eine Begriffsbestimmung der Schocklunge gegeben.
    Notes: Summary Although the pathogenesis of the so-called shock lung is different, from the clinical point of view the syndrome is uniform. Regarding the morphology microcirculation, vascular permeability and surfactant of the lung in shock lung are discussed. The course of the alterations in lung parenchyma is uniform, independent of the different pathogenesis in a single case. Pathology and disturbtion of lung function are conform. The relation of the so-called shock lung to other diseases of lung parenchyma is discussed and finally a definition of the so-called shock-lung recommendet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01254070
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