Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Onset Characteristics of Long-Term Potentiation in the Guinea-Pig Hippocampal CA1 Region in Vitro (1989)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 1 (1989), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The temporal development of long-term potentiation (LTP) was examined in the CA1 region of the hippocampal slice preparation (bath temperature 30°C). LTP was evoked by a single brief afferent tetanus (3–40 impulses at 50 Hz) given in the presence of picrotoxin (to facilitate LTP induction). Short-lasting potentiation processes unrelated to LTP were excluded by comparing the potentiation obtained in picrotoxin solution with that obtained in normal solution or in the presence of the N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonovalerate. LTP was also evoked by pairing single test volleys with brief (2–3 impulses) heterosynaptic tetani in picrotoxin solution. Both methods showed no significant rise of LTP until about 3 s after the induction event. LTP thereafter developed almost linearly towards a peak within 20–25 s after the tetanus, the time course being practially independent of the induction method and of the relative amount of LTP evoked. The latency and rise time of LTP depended on bath temperature, being about twice as long at 25°C as at 30°C. Following the peak, LTP rapidly decayed to less than half its peak value in 8 min, the decay tending to be less with longer trains. The LTP component reaching its peak 20–25 s after a tetanus was practically occluded after a saturating homosynaptic tetanization, and was only partially recovered 1 h afterwards. The latency to the onset of LTP suggests an indirect coupling between the calcium influx, presumed to trigger the potentiation, and the expression of LTP. The independence of the early time course with respect to the induction strength indicates that the intervening system(s) operates in a linear manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1989.tb00803.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Long-term Depression in the Hippocampal CA1 Region is Associated with Equal Changes in AMPA and NMDA Receptor-mediated Synaptic Potentials (1994)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 6 (1994), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In the CA1 hippocampal region low-frequency (1-2 Hz) afferent activation leads to a long-term depression of excitatory synaptic potentials that is induced by calcium influx through postsynaptic N-methyl-d-aspartate receptor channels. In the present experiments using 2- to 3-week-old rats, long-term depressions of field excitatory postsynaptic potentials mediated by amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and by N-methyl-d-aspartate receptor channels were examined in parallel, using a perfusion solution containing low concentrations of an AMPA receptor antagonist and of magnesium (0.1 mM). These experiments revealed that long-term depression was associated with equal relative changes in the two components of the field potential, compatible with a presynaptic location of the expression mechanism for the long-term depression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1994.tb00600.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A transient outward current in a mammalian central neurone blocked by 4-aminopyridine (1982)
    [s.l.] : Nature Publishing Group
    Nature 299 (1982), S. 252-254 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The experiments were performed on transverse slices (400-600 |xm thick) of guinea pig hippocampus. The slices were kept either half or totally immersed (see below) in an experimental chamber perfused with a solution containing (in mM): NaCl, 123; KC1, 3.0; CaCl2, 2.0; MgSO4, 2.0; NaHCO3, 26; ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/299252a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Specific long-lasting potentiation of synaptic transmission in hippocampal slices (1977)
    [s.l.] : Nature Publishing Group
    Nature 266 (1977), S. 736-737 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Figure 1 shows the location of a typical CA1 neurone with reference to the layers of the hippocampal slice, and the arrangement of the stimulating and recording electrodes used to study two independent pathways, one in the layer of basal dendrites (str. oriens) and the other in the layer of apical ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/266736a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    On the function of recurrent inhibition in the spinal cord (1979)
    Springer
    Experimental brain research 37 (1979), S. 399-403 
    Details
    ISSN: 1432-1106
    Keywords: Recurrent inhibition ; Renshaw cells ; Spinal cord
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recurrent inhibition of α-motoneurons, via motor axon collaterals and Renshaw cells, obviously reduces the response (output) from a motor nucleus to a given synaptic input. It is proposed that the supraspinal convergence on Renshaw cells allows recurrent inhibition to serve as a variable gain regulator at motoneuronal level. This would allow for an optimal resolution in the force control during weak as well as strong contractions. Renshaw cells are not only inhibiting α-motoneurons but also γ-motoneurons and Ia inhibitory interneurons. It is argued that this distribution is meaningful since all these receptive neurons act together as a functional unit, forming an “output stage” of the motor system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237722
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Facilitated induction of hippocampal long-lasting potentiation during blockade of inhibition (1983)
    [s.l.] : Nature Publishing Group
    Nature 301 (1983), S. 603-604 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Experiments were performed on transverse hippocampal slices from guinea pigs (n = 8) using standard techniques10. CA1 pyramidal cells were synaptically activated by electrical stimulation of fibres in the apical dendritic layer (Fig. IA, B), and the field potentials evoked in this layer and in the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/301603a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    A neuron model with learning capability and its relation to mechanisms of association (1973)
    Springer
    Biological cybernetics 12 (1973), S. 204-215 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract A neuron model with the ability of learning has been examined by means of mathematical and statistical methods. By use of the established anatomical concepts the main features of the model can be described as follows. The synapses are randomly distributed on the dendrites in a way that can be described by poisson processes. The afferent connections to the synapses are also random. The input signals are divided into excitatory, inhibitory and unspecified signals. The latter, whose detailed action is not specified, may involve excitatory as well as inhibitory action on the cell. Signals are described in terms of impulse frequencies. Learning takes place through facilitation of excitatory synapses. The condition for facilitation is the occurrence of simultaneous presynaptic and postsynaptic activity. The synaptical changes occurring during repeated learning are superimposed. Inhibitory synapses are capable of influencing learning by blocking the dendritic transmission. It is shown that, under certain conditions, a collection of model cells is able to work as an associative memory. This means that a pattern of output signals that once occurred through the combined action of the excitatory, the inhibitory, and the unspecified signals may later be recalled by applying just the two former signal patterns. It is shown that excitatory and inhibitory signals are similar in their ability to evoke associations. However there is also a difference between excitation and inhibition due to the fact that the pattern of inhibitory signals is subject to a non-linear transformation. This implies that great similarity is required between the inhibitory pattern once present during learning and the inhibitory pattern that is fed in later in order to obtain an associative recall. This phenomenon is called pattern separation and is supposed to be of importance when discriminating between patterns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270573
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...