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  • 1
    Digitale Medien
    Digitale Medien
    ACUTE LIVER DISEASE WITH ENCEPHALOPATHY AND RENAL FAILURE IN LATE PREGNANCY AND THE EARLY PUERPERIUM A STUDY OF FOURTEEN PATIENTS (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Fourteen patients, aged 18 to 38 years, presented in the last trimester of pregnancy, or immediately post partum, with severe acute hepatic dysfunction. Liver biopsy confirmed the presence of acute fatty liver in six patients; the cause of hepatic dysfunction was presumed viral hepatitis in five patients, pre-eclampsia in two, and gram-negative septicaemia in one. There was one set of twins and the perinatal mortality was 33 per cent; there were three maternal deaths (21 per cent). Two survivors with acute fatty liver subsequently had successful pregnancies without evidence of hepatic dysfunction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04465.x
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  • 2
    Digitale Medien
    Digitale Medien
    URINARY STEROID PROFILES AND ALOCHOL-RELATED BLOOD PRESSURE ELEVATION (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 18 (1991), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. From an earlier cross-sectional survey of 343 public servants, 15 pairs of non-smoking teetotallers and heavy drinkers (alcohol intake more than 350 mL/week) were matched for age and adiposity and utilized for a case-control study of the effects of alcohol on 11β-hydroxysteroid dehydrogenase (11β-OHSD) activity and blood pressure.2. Two successive 24 h urine collections were analysed by radio-immunoassay (RIA) for cortisol excretion, and for the cortisol and cortisone metabolites, tetrahydrocortisol (THC), allo-tetrahydrocortisol (allo-THC) and tetrahydrocortisone (THE), by capillary column gas chromatography.3. Heavy drinkers had higher systolic and diastolic blood pressure (BP) than teetotallers (132.6 ± 2.5 vs 123.2 ± 1.3 and 78.7 ± 1.6 vs 71.7 ± 1.4, respectively; unpaired t-test, P〈0.01). Twenty-four-hour urinary sodium and cortisol excretion were similar in the two groups.4. The THC plus allo-THC: THE ratio was similar in drinkers and teetotallers (1.81 ± 0.20 vs 2.03 ± 0.20), consistent with no effect of alcohol on 11β-OHSD activity. The ratio of THC to allo-THC was increased in drinkers compared with teetotallers (1.49 ± 0.18 vs 1.05 ± 0.13; unpaired t-test, P〈0.05), consistent with either a decrease in 5α-reductase activity or an increase in 5β-reductase activity.5. This study provides no evidence for alcohol-related inhibition of 11β-OHSD, despite substantially higher blood pressures in heavy drinkers compared to teetotallers. Such an effect is, therefore, unlikely to contribute significantly to the mechanism of alcohol-related hypertension. The increase in the THC: allo-THC ratio is consistent with a redox effect on steroid metabolism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1991.tb01447.x
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  • 3
    Digitale Medien
    Digitale Medien
    Preservation of gastric antral mucus is associated with failure of eradication of Helicobacter pylori by bismuth, metronidazole and tetracycline (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 8 (1994), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Methods: Forty-three patients positive for Helicobacter pylori by histology and culture of antral biopsies (n = 40) or histology alone (n= 3) were investigated. They received either regimen 1-tripotassium dicitrato bismuthate 120 mg q.d.s. and tetracycline 250 mg q.d.s. for 4 weeks, with metronidazole 200 mg q.d.s. for the first 2 weeks, or regimen 2–omeprazole 20 mg b.d., amoxycillin 500 mg t.d.s., tetracycline 500 mg q.d.s. each for 3 weeks. Gastric antral biopsies were scored (0–3) histologically for mucus depletion, polymorphonuclear and mononuclear cell infiltrate. H. pylori eradication was assessed by biopsy and culture 1 month after the cessation of treatment. Results: With regimen 1, pre-treatment mucus depletion was significantly higher where eradication was successful (median score 2) compared to where it was not (median score 1, P 〈 0.01): there were no differences in the scores for polymorphonuclear or mononuclear cell infiltrates. In patients receiving regimen 2, there were no differences in either mucus depletion or polymorphonuclear or mononuclear cell infiltrate, between those where eradication was successful and those where it was not. Metronidazole minimum inhibitory concentrations rose when eradication with regimen 1 was unsuccessful (median before 0.19 mg/L, median after treatment 16 mg/L; P = 0.04). Conclusion: Pre-treatment mucus depletion is identified as a factor affecting H. pylori eradication. Preservation of mucus may facilitate acquisition of metronidazole resistance.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2036.1994.tb00276.x
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  • 4
    Digitale Medien
    Digitale Medien
    Regression of columnar lined (Barrett's) oesophagus with continuous omeprazole therapy (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 7 (1993), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Twenty-three adult patients with a columnar lined (Barrett's) oesophagus are being treated with long-term omeprazole, 40 mg daily. Twelve had never undergone anti-reflux surgery (Group 1), the other eleven having previously had insertion of an Angelchik anti-reflux prosthesis (Group 2). Endoscopy was carried out six months before, immediately before and six months, one year and two years into treatment. Multiple and standardized biopsies were taken at each endoscopy. Results from the two groups were similar. During the 6-month run-in period there was a statistically non-significant increase in the linear extent of the columnar mucosa, but this showed a progressive, statistically significant decrease during the two years of treatment. Other evidence for regression of the Barrett's mucosa includes the emergence of large numbers of macroscopic squamous islands within the abnormal mucosa, an increase in the number of microscopic squamous islands, and microscopic squamous encroachment of the abnormal mucosa at the squamocolumnar junction. Histological assessment showed a reduction in the proportion of sulphomucin-rich intestinal metaplasia, but this only achieved statistical significance in Group 1. The results substantiate the importance of acid in the pathogenesis of Barrett's oesophagus. Omeprazole may have a therapeutic role in bringing about regression of the metaplastic epithelium.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2036.1993.tb00143.x
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  • 5
    Digitale Medien
    Digitale Medien
    An Eudragit-coated prednisolone preparation for ulcerative colitis: pharmacokinetics and preliminary therapeutic use (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 6 (1992), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Prednisolone metasulphabenzoate, a steroid with poor colonic absorption, was coated with the pH-dependent acrylic resin Eudragit S, as a means of delivering an orally administered preparation to the proximal colon. The therapeutic potential of delivering this steroid with potentially less systemic side-effects to the proximal colon was assessed in extensive ulcerative colitis. Plasma and urine prednisolone profiles in 6 healthy volunteers confirmed minimal absorption from Eudragit S-coated prednisolone metasulphabenzoate compared to prednisolone acetate: peak plasma prednisolone concentrations 29 ± 21 ng/ml vs. 570 ± 185 ng/ml (P 〈 0.01), area under curve measurements 204 ± 214 vs. 2724 ± 1236 ng.h/ml (P 〈 0.01). Prednisolone metasulphabenzoate coated with Eudragit S (30–60 mg daily) was then administered for 12 weeks to 12 patients with colonoscopically proven extensive ulcerative colitis in relapse. Symptoms, sigmoidoscopic appearances and rectal histological abnormalities all improved during therapy. Complete clinical remission occurred in 7 patients, a partial response in 2 patients and no response in 3 patients. Cortisol responses to tetracosactrin demonstrated no significant adrenal suppression following treatment. Eudragit S-coated prednisolone metasulphabenzoate may be a useful treatment for extensive ulcerative colitis, without risk of systemic steroid side-effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2036.1992.tb00542.x
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  • 6
    Digitale Medien
    Digitale Medien
    Symptom relief and duodenal ulcer healing with omeprazole or cimetidine (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 3 (1989), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: In a double-blind parallel-group study, 98 patients with symptomatic duodenal ulcer received omeprazole 20 mg o.m. and 91 cimetidine 800 mg nocte for 2 or, if then not healed, 4 weeks. After 2 weeks the healing rates on an intention-to-treat basis were: for omeprazole 62% and for cimetidine 33% (P 〈 0.001), and at 4 weeks 85% and 61%, respectively (P 〈 0.001). The proportions symptom-free at 2 weeks were 83% of the omeprazole and 63% of the cimetidine-group (P 〈 0.01) and at 4 weeks 84% and 72% (P= 0.01). Patients receiving omeprazole took fewer antacid tablets than those receiving cimetidine. Patient tolerance of both drugs was similar and good. In the treatment of duodenal ulcer, omeprazole 20 mg o.m. gives faster symptom relief than cimetidine 800 mg nocte, as well as healing a greater proportion of ulcers within 2 and 4 weeks.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2036.1989.tb00193.x
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  • 7
    Digitale Medien
    Digitale Medien
    The limits of endoscopy in the diagnosis of oesophagitis, gastritis and duodenitis (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Endoscopy alone, without histology, has poor sensitivity and specificity for diagnosing diffuse mucosal diseases of the oesophagus, stomach and duodenum. Erosive lesions with exudate at the distal end of the oesophagus are a reliable sign of oesophagitis, but are present in only approximately 50% of patients with gastro-oesophageal reflux. Erythema and friability are unreliable are subject to considerable inter-observer variation. Numerous macroscopic abnormalities of the gastric and duodenal mucosa have been identified, but these show no consistent histological pattern.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2036.1997.tb00788.x
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  • 8
    Digitale Medien
    Digitale Medien
    The hepatorenal syndrome revisited (1987)
    Springer
    Intensive care medicine 13 (1987), S. 145-147 
    Details
    ISSN: 1432-1238
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00254696
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  • 9
    Digitale Medien
    Digitale Medien
    Endoscopic crescentic fold disease of the sigmoid colon: the clinical and histopathological spectrum of a distinctive endoscopic appearance (1992)
    Springer
    International journal of colorectal disease 7 (1992), S. 76-81 
    Details
    ISSN: 1432-1262
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Dans ce papier nous décrivons un aspect endoscopique du colon sigmoïde caractérisé par une enflure de la muqueuse, un érythème et des hémorragies strictements localisées aux plis muqueux en croissant. Durant une période de trois ans ces modifications ont été retrouvées chez 34 (1,42%) de 2380 coloscopies ou sigmoïdoscopies. La majorité des patients étaient d'un age moyen ou âgé. Une maladie diverticulaire était présente chez la plupart d'entre eux (82%) mais les anomalies étaient localisées aux plis muqueux en croissant épargnant les orifices diverticulaires. La majorité des patients présentaient une histoire d'hémorragie par l'anus. Histologiquement il y avait une variété de modifications allant d'une congestion vasculaire mineure à une inflammation active avec des anomalies architecturales décrites simulant la colite ulcéreuse, mais les biopsies rectales étaient invariablement normales. Trois malades ont fait par la suite une colite ulcérative distale typique et deux autres se présentant à nous avec une maladie endoscopique des plis en croissant avaient une préalable histoire documentée histologiquement de colite ulcérative distale. Ches trois patients les aspects histologiques étaient ceux d'un prolapsus muquene environ la moitié des patients ont en besain d'une thérapié quelconque pour contrôler leurs symptomes. Les stéroïdes et/ou la sulfasalazine fûrent actifs bien que deux patients subirent par la suite une résection sigmoïdienne, l'un pour contrôler une hémorragie et le second pour une sténose diverticulaire associée. Tandis que la maladie endoscopique des plis en croissant représente un aspect spécifique de l'endoscopie, les aspects cliniques et histologiques révèlent une large variété de maladies.
    Notizen: Abstract In this paper we describe an endoscopic appearance of the sigmoid colon characterised by mucosal swelling, erythema and haemorrhage strictly localised to the crescentic mucosal folds. In a 5-year period these changes were seen in 34 (1.42%) of 2380 colonoscopies and fibreoptic sigmoidoscopies. The majority of patients were middle-aged or elderly. Diverticular disease was present in most (82%) but the abnormalities were confined to the crescentic mucosal folds with sparing of the diverticular orifices. The majority of patients presented with a history of bleeding per anum. Histologically there was a spectrum of changes varying from minor vascular congestion to florid active inflammatory disease with crypt architectural abnormalities mimicking ulcerative colitis, but rectal biopsies were invariably normal. Three patients later progressed to typical distal ulcerative colitis and two other patients presenting to us with endoscopic crescentic fold disease had a previous histologically documented history of distal ulcerative colitis. In three patients the histological features were of mucosal prolapse. About half the patients required some form of therapy to control their symptoms. Steroids and/or sulphasalazine were of value although two patients subsequently underwent sigmoid resection, one to control bleeding and the second for a diverticulosis-associated stricture. Whilst endoscopic crescentic fold disease represents a specific endoscopic appearance the clinical and histological features indicate a wide spectrum of disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00341290
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  • 10
    Digitale Medien
    Digitale Medien
    Significance of immediate diuresis in relation to transplant kidney survival rate (1986)
    Springer
    International urology and nephrology 18 (1986), S. 453-455 
    Details
    ISSN: 1573-2584
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Transplant kidney survival of recipients with immediate diuresis (n=19) is compared with recipients who did not have a significant post-operative diuresis (n=53). There is statistically no significant difference between patients without significant early diuresis (survival rate 71%) and patients with immediate diuresis (survival rate 68%, p〉0.1). The renal function was not different in the survivors of the two groups at 12 months post-transplant as measured by creatinine clearance (p〉0.35).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02084118
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