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  • 1
    Electronic Resource
    Electronic Resource
    Early recurrence of hyperthyroidism in patients with Graves' disease treated by subtotal thyroidectomy (1995)
    Springer
    World journal of surgery 19 (1995), S. 648-652 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le traitement chirurgical de la Maladie de Basedow se doit d'être non seulement sûr mais doit aussi éviter un taux excessif de récidive d'hyperthyroïdie. La récidive précoce est particulièrement fâcheuse. Nous avons étudié 728 patients atteints de Maladie de Basedow, traités par thyroïdectomie subtotale, en analyse multifactorielle, de façon à détecter les facteurs éventuels de récidive précoce. On a analysé les facteurs suivants: âge, sexe, durée du traitement médical, le poids del la pièce réséquée, la taille du moignon restant, les niveaux préopératoires de TSH binding inhibitory immunoglobuline (TBII) et des anticorps antimicrosomial hemagglutination (MCHA). On a utilisé le test Chi2 en analyse monofactorielle et, par modèle logistique, pour l'analyse multifactorielle. La récidive précoce a été définie par l'existence d'une suppression de la TSH observée pendant la première année après la chirugie et durant au moins 6 mois. Cent six patients (14.67%) ont eu une récidive précoce. Les facteurs significatifs étaient la taille du moignon, le MCHA et 1 TBII. Ces résultats indiquent que TBII et MCHA sont des facteurs de récidive précoce. Chez le patient ayant des taux élevés de TBII et MCHA, il vaut mieux réduire d'avantage la taille du moignon pour éviter les risques de récidive précoce.
    Abstract: Resumen Un prerrequisito para el tratamiento quirúrgico de la enfermedad de Graves es que pueda ser realizado no sólo con seguridad sino también con una baja incidencia de hipertiroidismo recurrente. La recurrencia temprana es especialmente indeseable. Hemos estudiado 728 pacientes con enfermedad de Graves tratados mediante tiroidectomía subtotal utilizando análisis multivariable con miras a identificar los factores que se relacionan con recurrencia temprana. Los siguientes factores fueron analizados: edad, sexo, duración del tratmiento médico, peso del tejido tiroideo resecado, tamaño del remanente tiroideo, nivel sérico preoperatorio de inmunoglobulina inhibidora de la ligadura de TSH (TBII) y de anticuerpo antimicrosomal de hemaglutinación MCHA). Se definió la “recurrencia temprana” como la supresión de TSH que ocurre en el curso del primer año luego de la cirugía y que se continúa por lo menos por 6 meses. Ciento seis pacientes, 14.6%, presentaron recurrencia temprana. El análisis estadístico demostró que el remanente de tiroides, el MCHA y la TBII fucron los factores de significación. Estos resultados indican que la TBII y el MCHA están relacionados con el fenómeno de la recurrencia temprana del hipertiroidismo y por ello se recomienda, para evitar tal recurrencia, un remanente tiroideo menor en los pacientes con MCHA elevada y/o nivel elevado de TBII.
    Notes: Abstract Prerequistes for surgical treatment of Graves' disease are that it can be done safely and that it is associated with a low incidence of recurrent hyperthyroidism. Early recurrence is especially undesirable. We studied 728 patients with Graves' disease treated by subtotal thyroidectomy using multivariate analysis in order to determine the factors related to early recurrence. The following factors were analyzed: age, sex, duration of medical treatment, weight of resected thyroid tissue, thyroid remnant size, preoperative level of thyroid-stimulating hormone (TSH) binding inhibitory immunoglobulin (TBII), and antimicrosomal hemagglutination antibody (MCHA). “Early recurrence” was defined as TSH suppression observed within the first year after surgery and continuing for at least 6 months. A total of 106 patients (14.6%) had early recurrence. Statistical analyses were performed by the chi-square test for univariate analysis and a logistic model for multivariate analysis. Significant factors were thyroid remnant size, MCHA, and TBII. These results indicated that TBII and MCHA are related to early recurrence of hyperthyroidism, and smaller remnant size is recommended for patients with a high MCHA titer or a high TBII level (or both) in order to avoid early recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294748
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular Dynamics Study of Oxygen Vacancy Diffusion in BaTiO〈sub〉3〈/sub〉 Doped with Rare Earth Ions (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 388 (Sept. 2008), p. 269-272 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Atomistic mechanisms that restrain diffusion of oxygen vacancies in BaTiO3 doped with rare earthions as donors were analyzed using molecular dynamics simulation. It was confirmed that formationof cation vacancies and reduction of lattice volume are sources of resistance for the diffusion. Thecation vacancies trap the oxygen vacancies at the nearby O2- sites by an attractive force associatedwith Coulombic interaction. In contrast, the rare earth ions repel the oxygen vacancies, whichmigrate via O2- sites, and accelerate the diffusion. This is one of the factors that determine therestraint behavior of the diffusion, which depends on the type of rare earth ion in BaTiO3-basedmaterials
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/57/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.388.269.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Changes in the Electrical Conduction Mechanism with the Electrical Degradation of BaTiO〈sub〉3〈/sub〉-Based Ceramics (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 388 (Sept. 2008), p. 201-204 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The electrical degradation mechanisms of BaTiO3-based ceramics were investigated bymeasuring the dependence of leakage current on high electric fields. Before the degradation, theleakage current predominately obeyed Ohm’s law and Poole-Frenkel relation. As the degradationprogressed, the Poole-Frenkel emission current increased. Moreover, the total current at the highelectric fields also comprised Schottky emissions between cathodes and dielectric layers
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/57/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.388.201.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Preoperative Change of Thyroid Stimulating Hormone Receptor Antibody Level: Possible Marker for Predicting Recurrent Hyperthyroidism in Patients with Graves’ Disease after Subtotal Thyroidectomy (1996)
    Springer
    World journal of surgery 20 (1996), S. 801-807 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. To make the surgical treatment for Graves’ disease more ideal, it is important to elucidate factors related to postoperative thyroid dysfunction in addition to thyroid remnant. Because TSH receptor antibody (TRAb) is thought to be one of the essential causes of Graves’ disease, we investigated whether preoperative changes in serum TRAb levels are related to postoperative recurrent hyperthyroidism. Between 1987 and 1992 a total of 1520 patients with Graves’ disease were treated by subtotal thyroidectomy. Of these patients 335 visited Ito Hospital with no history of drug treatment of their disease and were treated surgically after several courses of antithyroid drug (ATD) therapy. There were 68 males and 267 females with a mean age of 25.8 years. The mean follow-up period was 48 months (range 12–84 months). Factors analyzed by univariate and multivariate analysis were as follows: age, sex, duration of ATD treatment, weight of resected thyroid, weight of thyroid remnant, preoperative titer of MCHA, TRAb at the time of initial examination (TRAb1), TRAb at the time of surgery (TRAb2), and ΔTRAb, the difference between TRAb1 and TRAb2 (ΔTRAb = TRAb1 − TRAb2). The chi-square test was used for univariate analysis and a logistic model for multivariate analysis. Of this group, 119 patients were euthyroid (35.5%), 50 were hyperthyroid (14.9%), and 166 were hypothyroid (49.3%). Significant factors related to recurrent hyperthyroidism were weight of thyroid remnant and ΔTRAb in both univariate and multivariate analyses. ΔTRAb is a possible new marker for predicting postoperative recurrent hyperthyroidism. If the preoperative TRAb level is not improved by ATDs in patients with Graves’ disease, the thyroid remnant should be made smaller.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002689900122
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  • 5
    Electronic Resource
    Electronic Resource
    Postoperative Changes in Thyrotropin-binding Inhibitory Immunoglobulin Level in Patients with Graves' Disease: Is Subtotal Thyroidectomy a Suitable Therapeutic Option for Patients of Childbearing Age with Graves' Disease? (1999)
    Springer
    World journal of surgery 23 (1999), S. 727-731 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Thyroid-stimulating hormone (TSH)-binding inhibitory immunoglobulin (TBII) is thought to be one of the essential causes of Graves' disease, and most cases of neonatal hyperthyroidism can be explained by transplacental passage of TBII. Because surgery is often indicated for patients of childbearing age, it is important to elucidate how surgery reduces TBII levels. Between 1988 and 1991 a total of 946 female patients with Graves' disease underwent subtotal thyroidectomy. Follow-up examination was undertaken at 1, 2, 3, and 4 to 5 years after surgery. At 4 to 5 years after surgery, 76.8% of patients without recurrent overt hyperthyroidism had TBII 〈 20%. In patients with recurrent hyperthyroidism, TBII increased gradually during follow-up, and they had higher TBII levels than nonrecurrence patients. There were a few euthyroid and hypothyroid patients who had TBII 〉 60%, and the number of such patients decreased annually. In most of the patients, immunologic remission was obtained by subtotal thyroidectomy except for their having recurrent hyperthyroidism. To acquire immunologic remission, hormonal remission, at least, would be necessary. Because no definite factor other than the size of the thyroid remnant related to postoperative thyroid function was elucidated, near-total thyroidectomy rather than subtotal thyroidectomy is expected to be induced not only hormonal remission but also immunologic remission. It should be noted that a few patients achieved hormonal remission but not immunologic remission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012377
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  • 6
    Electronic Resource
    Electronic Resource
    PCNA and Ki-67 as Prognostic Markers in Human Parathyroid Carcinomas (2000)
    Springer
    Annals of surgical oncology 7 (2000), S. 301-305 
    Details
    ISSN: 1534-4681
    Keywords: Parathyroid carcinoma ; PCNA ; Ki-67 ; Labeling index.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: It is widely accepted that histological diagnosis of parathyroid tumors is established with great difficulty. Carcinomas cannot be reliably separated from adenomas by histology alone. In this study, immunohistochemical staining for proliferating cell nuclear antigen (PCNA) and Ki-67 was determined in 10 cases of parathyroid carcinomas, labeling indices (LIs) were calculated, and the results were correlated with the clinical outcomes. Methods: Ten cases of formalin-fixed, paraffin-embedded tissue with surgically resected parathyroid carcinoma were used. Immunohistochemical staining for PCNA and Ki-67 was performed and the LIs were calculated. We also examined whether LI could become a useful marker for parathyroid carcinomas. Results: Although nine patients with minimally invasive growth without recurrence of the tumor showed a low LI for both markers, one patient with a widely invasive neoplasm, and who died, had a high LI. Conclusions: These results suggested that the LI of PCNA and Ki-67, in addition to the histological appearance, may be markers of the biological behavior of parathyroid carcinomas. However, this study was on a small scale, so it may be valuable to repeat these studies in a larger group of patients with better defined histological criteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s10434-000-0301-9
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