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  • 1
    Electronic Resource
    Electronic Resource
    Nisoldipine in primary Raynaud's phenomenon (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 27-30 
    Details
    ISSN: 1432-1041
    Keywords: nisoldipine ; Raynaud's phenomenon ; platelet function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The efficacy and tolerability of the dihydropyridine derivative nisoldipine was assessed in 36 patients with primary Raynaud's phenomenon. Nisoldipine was given at doses of 5 mg and 10 mg daily for one month each in a placebo controlled double-blind cross-over trial. There was no subjective improvement in symptoms or changes in resting finger blood flow, platelet aggregability or red cell deformability after nisoldipine. The incidence of unwanted effects was similar to that previously described with nifedipine, suggesting that plasma concentrations of nisoldipine were sufficient to cause pharmacodynamic effects. Nisoldipine, in contrast to nifedipine is ineffective in the treatment of primary Raynaud's phenomen when given in a dose of up to 10 mg/day.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00610375
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  • 2
    Electronic Resource
    Electronic Resource
    Is xamoterol safe in chronic airflow obstruction? (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 147-150 
    Details
    ISSN: 1432-1041
    Keywords: Xamoterol ; Chronic airflow obstruction ; non-specific bronchial responsiveness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have demonstrated in a group of 10 patients with CAO that treatment with xamoterol (200 mg b.i.d. for 7 days) did not alter lung function or respiratory symptoms. These results suggest that xamoterol can be used to treat mild heart failure in patients with CAO.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278474
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  • 3
    Electronic Resource
    Electronic Resource
    The influence of levodopa on gastric emptying in healthy elderly volunteers (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 409-412 
    Details
    ISSN: 1432-1041
    Keywords: Levodopa ; Gastric emptying ; paracetamol ; elderly subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Paracetamol absorption and 99Tc-DTPA measurements have been used to determine the influence of levodopa on gastric emptying in 8 healthy elderly volunteers. In the absence of levodopa 7 subjects showed a rapid gastric emptying pattern by gamma-camera and a single major peak in the plasma concentration-time curve of paracetamol. One subject showed two rapid phases of gastric emptying separated by a period of negligible emptying and had 2 separate peaks in the paracetamol plasma concentration-time curve. In the presence of levodopa, the gamma-camera data for 6 subjects showed a pattern of gastric emptying consisting of 2 rapid phases separated by a plateau. In each case secondary peaks in the plasma concentration-time curve of paracetamol occurred about 30 min after the end of the plateau. The time to 90% emptying on the gamma scan was increased significantly from 40 min to 65 min in the presence of levodopa. Comparison of the present data with those reported previously indicates that levodopa affects gastric emptying in the both elderly and young volunteers to a similar extent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280127
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  • 4
    Electronic Resource
    Electronic Resource
    Xamoterol improves right ventricular systolic and diastolic function in pulmonary heart disease (1996)
    Springer
    European journal of clinical pharmacology 50 (1996), S. 31-36 
    Details
    ISSN: 1432-1041
    Keywords: Key words Pulmonary heart disease ; Xamoterol; right ventricular function ; radionuclide ventriculography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract. Objective: Abnormal right ventricular function in patients with pulmonary heart disease (PHD) may contribute to their reduced exercise capacity. We have evaluated the effect of subacute dosing with xamoterol, a beta-1 adrenoreceptor partial agonist with inotropic properties, on right ventricular function in patients with PHD. Patients: Twelve patients with advanced chronic obstructive pulmonary disease and clinical evidence of PHD received xamoterol 200 mg twice daily or placebo for 7 days in a randomised double-blind crossover study. Right heart krypton-81m radionuclide ventriculography was used to derive right ventricular ejection fraction (RVEF) both at rest and during submaximal exercise, and indices of right ventricular systolic and diastolic function at rest. Results: During treatment with placebo, mean RVEF was 0.53 at rest and was unchanged during exercise. After xamoterol, mean RVEF was 0.55 at rest and increased to 0.59 during exercise. Xamoterol increased right ventricular peak ejection rate from 3.04 to 3.45 EDV⋅s–1 and mean early diastolic filling rate from 1.00 to 1.20 EDV⋅s–1. Conclusion: Subacute treatment with xamoterol in patients with PHD improves right ventricular systolic and diastolic function at rest and results in a favourable augmentation in right ventricular function during submaximal exercise.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050065
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  • 5
    Electronic Resource
    Electronic Resource
    Ischaemic left ventricular dysfunction: a preventable precursor of heart failure? (1998)
    Springer
    European journal of clinical pharmacology 53 (1998), S. 379-388 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050398
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  • 6
    Electronic Resource
    Electronic Resource
    Factors affecting the pharmacokinetics of nifedipine (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 351-355 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; cimetidine ; pharmacokinetics ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma pharmacokinetics of nifedipine and the formation of its metabolites have been studied in volunteers under conditions which would affect the activity of the cytochrome P-450 system. The pharmacokinetics of a 10-mg capsule of nifedipine were not significantly different between smokers and non-smokers of similar age. After pretreatment with cimetidine, which inhibits the activity of cytochrome P-450, the peak plasma concentration and area under the plasma-time concentration curve for nifedipine were increased by a mean 84%. In contrast, pre-treatment with ranitidine which has little effect on cytochrome P-450, did not significantly alter nifedipine pharmacokinetics. Smoking does not contribute significantly to the variability in nifedipine pharmacokinetics. However, the interaction between nifedipine and cimetidine, but not ranitidine, may be of clinical importance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543968
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  • 7
    Electronic Resource
    Electronic Resource
    The circulating renin-angiotensin system and the response to hypotension (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 23 (1993), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1993.tb00358.x
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  • 8
    Electronic Resource
    Electronic Resource
    Comparison of radionuclide estimation of glomerular filtration rate using technetium 99m diethylenetriaminepentaacetic acid and chromium 51 ethylenediaminetetraacetic acid (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 391-395 
    Details
    ISSN: 1619-7089
    Keywords: Glomerular filtration rate ; Technetium 99m diethylenetriaminepentaacetic acid ; Chromium 51 ethylenediaminetetraacetic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Simultaneous measurements of the clearance rates of technetium 99m diethylenetriaminepentaacetic acid (99mTc-DTPA) and chronium 51 ethylenediaminetetraacetic acid (51Cr-EDTA) were performed in 30 patients with a range of renal function (glomerular filtration rates between 9 and 120 ml/min). Using multiple blood samples, the two clearance values correlated well (r=0.991, standard error 3.9 ml/min), but DTPA clearance was systematically higher by 7.6%. For each radiopharmaceutical, an equation was derived to correct clearance values obtained using only plasma samples taken at 2 and 4 h for the systematic error inherent in this technique compared with analysis of the complete plasma concentration-time curve. The root mean square error remaining after application of these equations was 1.9 ml/min for both the EDTA and DTPA data. The corresponding errors obtained using the equation derived by Brochner-Mortensen for EDTA plasma clearance were 2.2 ml/min and 1.9 ml/min, respectively, these values were not significantly different from those obtained using the equations derived in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02258429
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  • 9
    Electronic Resource
    Electronic Resource
    The influence of two types of meal on the pharmacokinetics of a modified-release formulation of nifedipine (Adalat Retard) (1997)
    Springer
    European journal of clinical pharmacology 53 (1997), S. 141-143 
    Details
    ISSN: 1432-1041
    Keywords: Key words Nifedipine; drug absorption ; food
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The effect of two different types of meal on the absorption of a modified-release formulation of nifedipine (Adalat Retard) was studied. Results: A light breakfast produced a delay in gastric emptying (indicated by the rate of paracetamol absorption) compared with the fasting state, but did not alter the tmax or Cmax for nifedipine significantly. After a cooked breakfast, there was less delay in gastric emptying and again no delay in tmax for nifedipine. However, the Cmax for nifedipine was significantly higher than in the fasting state. Neither meal influenced the bioavailability of nifedipine. Conclusion: The results suggest that the nature of the meal has an important influence on the absorption profile of this formulation of nifedipine, probably by an effect on its dissolution. This study illustrates the importance of considering the effects of different types of meal before concluding that food does not affect the pattern of drug absorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050352
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