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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 10 (1973), S. 42-50 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary Many OCC are at present current constituents of the global ecosystem. Their biological effects are of great interest to ecologists and environmental toxicologists. This paper deals with the interrelationship between OCC (p,p′-DDT, Dieldrin and Arochlor 1221) and the serum level of protein fractions in rabbits receiving the above-mentioned compounds. Sixty rabbits were divided into 6 groups given respectively no OCC, 200 ppm p,p′-DDT, 50 ppm Dieldrin, 200 ppm Arochlor-1221, 100 ppm p,p′-DDT and 100 ppm Arochlor-1221, 25 ppm Dieldrin and 100 ppm Arochlor in their drinking water which contained 6‰ ethyl alcohol in all groups. After p,p′-DDT administration the increased plasma levels of DDT were accompanied by increased levels of Dieldrin,γ-BHC and PCBs, although the animals did not receive extra dosage of these OCC, except the amounts currently present in food and water. Dieldrin administration led to a concomitant increase in total DDT plasma level. A moderate increase in total DDT plasma level occurred also after the administration of PCBs. When administered concomitantly, in half doses, the same results were obtained at a lower level. Variations in plasma level of different OCC as a result of feeding a given compound may explain differences in the degree of toxicity based on the resultant of metabolic interrelationships of OCC in the animal body. The serum level of gamma globulin fractions (IgG and IgM) shows a tendency to decrease in rabbits given OCC. The serum albumin level rose in rabbits receiving OCI and fell in those receiving PCBs. In regard to the biological effects of OCC these facts point to a moderation of the activity of the immunological system.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 12 (1974), S. 501-508 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary In the framework of a WHO — International Agency Program for Research on Cancer, people from five African, three Asian, and two South American countries were studied for the storage level of organochlorine insecticide storage in the adipose tissue of Ugandans. Specimens of adipose tissue (75) collected during autopsy from Ugandans living in the Kampala area, who had no occupational exposure to organochlorine insecticides were analyzed by the gas chromatographic method for organochlorine insecticides (DDT-derived material, the beta isomer of BHC, dieldrin and heptachlor epoxide). In the 0–4 year age group, DDT-derived material averaged 2.3 ppm; DDT constituted 59.6% of total DDT. In the 5–24 year age group, total DDT averaged 3.84 ppm. DDE constituted 50.2% of total DDT. In the 25–44 year age group, total DDT averaged 2.9 ppm DDE constituted 63.2% of total DDT. In the 45 and over age group, total DDT averaged 2.4 ppm and DDE constituted 53.6% of total DDT. Dieldrin and the beta isomer of BHC were stored at levels below 0.1 ppm and heptachlor epoxide below levels of 0.2 ppm. Males generally stored more OCI than females. Lower storage levels of total DDT were observed in the group aged 45 years and over, when compared to the 5–24 and 25–44 year age groups. In comparison to other populations in Africa, Asia, and South America, people from Uganda stored the lowest amount of OCI. It is proposed that the 25–44 year age group may characterise the OCI storage level of a community since in this age group DDT-derived material tends to be stored at higher concentrations in the adipose tissue of people in several countries, when compared to lower age groups. (In the over 45 year age groups the level of DDT-derived material varies from country to country being higher or lower than in the 25–44 year age group.)
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 6 (1971), S. 85-88 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Conclusions This paper reports on the level of serum PBI in a group of 42 workers handling OCI as compared to a control group of 51 workers not occupationally exposed to these insecticides. Practically all the serum PBI values were within the range considered as normal. However, the serum PBI was significantly lower in workers occupationally exposed to OCI when compared to the non-occupationally exposed workers (p〈0.01). It is suggested that the presence of OCI in the human body affects the metabolism of thyroxine. Homeostasis is maintained by a sustained effort of the hypophyso-thyroid system.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 6 (1971), S. 426-435 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary Thirty-one rabbits were immunized against Salmonella or SRBC. These rabbits had an impaired immunological response when they received 200 ppm p,p′-DDT in their drinking water during a period of 38 days. The total gamma globulins as reflected by the 7 S fraction were significantly decreased in the p,p′-DDT-Salmonella receiving rabbits when compared with the rabbits receiving only Salmonella. This decrease was not statistically significant in the p,p′-DDT-SRBC receiving rabbits when compared with the rabbits receiving only SRBC. The antibody titer against Salmonella was significantly decreased in p,p′-DDT-Salmonella receiving rabbits when compared with the rabbits receiving only Salmonella. The decrease of the SRBC antibody titer in the p,p′-DDT-SRBC receiving rabbits was not statistically significant. The plasma total DDT level differed significantly in the two groups receiving p,p′-DDT (p,p′-DDT-Salmonella and p,p′-DDT-SRBC receiving rabbits). This finding may explain the different degree of impairment of the immunological response, the higher plasma DDT level having a more marked effect. These differences in total DDT plasma level in the two groups of rabbits which received the same amount of p,p′-DDT in their drinking water may be considered as a consequence of the concomitant presence of a different kind of foreign antigen in the internal milieu. The bi-directional relationship between a detoxication process and an immunological response is emphasized.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 320 (1979), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 160 (1969), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 20 (1978), S. 544-553 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 21 (1979), S. 533-538 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 15 (1976), S. 478-484 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 4 (1969), S. 327-336 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary Rats submitted to p,p′-DDT at 200 ppm in drinking water showed increased p, p′-DDT storage which was not statistically different from that of thyroidectomized rats receiving p, p′-DDT. Rats receiving p, p′-DDT also showed increased fat storage of total o, p′-DDT and Dieldrin and decreased total BHC storage. Thyroidectomy decreased the amount of p, p′-DDT naturally occurring in the animal body and raised the metabolization of this compound. In thyroidectomized rats submitted to the same dosage of p, p′-DDT, increased storage of p, p′-DDT, o, p′-DDT and Dieldrin was found. A statistically significant increase in BHC was also observed. It is concluded that p, p′-DDT in the diet may affect the storage level of other organochlorine insecticides depending on its concentration, and that the physiopathological state of the body, e. g. thyroidectomy has a definite influence on the storage of organochlorine insecticides in the animal body and on their biological effect.
    Type of Medium: Electronic Resource
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