ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
A group of Australian aborigines with a high frequency (15.5%) of asymptomatic Australia antigen (Au) carriers shows a statistically significant deficiency of W15 among Au carriers. The association was observed during an HL-A survey, and was confirmed by a further study designed to investigate the observed association. Further, the pooled data establish the association.The observed association can be explained satisfactorily in terms of an Au immune response locus closely linked with, and having alleles in linkage disequilibrium with alleles of, the Four locus of the HL-A system. Since a deficiency of W15 among Au carriers has been reported in a northern European study, though it has not been observed in others, it is argued that the association has not occurred by chance, but that selection involving both HL-A and immune response genes has been responsible for the observed association.A significantly high proportion of Au carriers were observed to be homozygous for antigens of the Four series. The data, and their interpretation, lend support to the proposition that asymptomatic Au carriers are homozygous for an inactive allele of the gene responsible for the immune response to Au.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1975.tb00518.x
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