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  • 1
    Electronic Resource
    Electronic Resource
    Idiopathic thrombocytopenic purpura in pregnancy and neonatal period (1984)
    Springer
    Annals of hematology 48 (1984), S. 377-382 
    Details
    ISSN: 1432-0584
    Keywords: ITP ; ITP in pregnancy ; Immune thrombocytopenia in the newborn ; Immunoglobulin therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In pregnancy and neonatal period both mother and child are endangered by bleeding complications due to maternal idiopathic thrombocytopenic purpura. Obstetrical and perinatal management therefore must aim at increasing maternal and fetal platelet count. In our paper six patients in nine pregnancies are reported. Two of them (five pregnancies) were treated with corticosteroids, four of the patients were successfully treated with i.v. immunoglobulins (IgG). Longterm steroid application and splenectomy during pregnancy may be hazardous for mother and fetus. IgG i.v. administration in contrast offers a new and safe way to control maternal and fetal platelet counts during pregnancy, delivery and the neonatal period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319966
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    β-Alanin-Vermehrung in Lympho- und Thrombocyten zur biochemischen Diagnose der Cystinose (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 1082-1084 
    Details
    ISSN: 1432-1440
    Keywords: Cystinosis diagnosis ofβ-alanine ; cystine ; lymphocytes ; platelets ; heterogyous twins ; Cystinose-Diagnose ; β-Alanin ; Cystin ; Lymphocyten ; Thrombocyten ; Heterozygotc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In den Lymphocyten von 6 Cystinose-Kranken konnte Cystin in einer Menge von 2,5 nMol/mg Protein nachgewiesen werden, während es in den Thrombocyten nur in Spuren gefunden wurde. Eine bisher nicht beschriebene Erhöhung wurde für eine andere Aminosäure gefunden, die wir säulenchromatographisch alsβ-Alanin identifiziert haben. Diese erreichte in Lymphocyten von 6 Cystinosen 4,5 nMol/mg Protein, in Thrombocyten 7,5 nNol/mg Protein. Die Bestimmung derβ-Alanin-Konzentration in Lymphocyten und Thrombocyten ist geeignet, für die biochemische Diagnose der Cystinose angewendet zu werden. Voraussetzung ist die Heranziehung einer Ultramikromethode. Heterozygote zeigten in denβ-Alanin-Konzentrationen keine Abweichungen von der Norm. Die Ursache derβ-Alanin-Erhöhung in Lymphocyten und Thrombocyten ist noch nicht geklärt.
    Notes: Summary In 6 patients with cystinosis, the cystine concentration in lymphocytes was 2.5 nMol/mg protein, while only traces of cystine were found in the platelets. A previously undescribed elevation of another amino acid was observed which was identified asβ-alanine by column chromatography in this laboratory. In 6 patients with cystinosis, this amino acid reached a concentration of 4.5 nMol/mg protein and of 7.5 nMol/mg protein in the platelets of 5 patients with cystinosis. The assessment of theβ-alanine concentrations in lymphocytes and platelets is suitable for biochemical diagnosis of cystinosis. Ultra-micromethods must of course be used.β-alanine concentrations in heterozygotes were not different from the norm. The cause of the increase inβ-alanine concentrations in lymphocytes and platelets could not yet be explained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486851
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Chromatin-Matrizenaktivität und Verhalten DNA-abhängiger RNA-Polymerase III in der Peri- und Postnatalperiode (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 449-450 
    Details
    ISSN: 1432-1440
    Keywords: Template activity of Chromatin ; RNA-Polymerase III rat liver ; Development ; Chromatin-Matrizenaktivität ; RNA-Polymerase III ; Rattenleber ; Entwicklung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Matrizenaktivität von Chromatin aus gereinigten Rattenleberzellkernen ist in der Fetalzeit niedrig, erreicht ihr Maximum um den 1. Lebenstag und steigt nach einem vorübergehenden Absinken vom 10.–40. Lebenstag allmählich auf Erwachsenenwerte an. Dieser Befund läßt sich mit entwicklungsspezifischen Aktivitätsveränderungen der DNA-abhängigen RNA-Polymerase III im Cytoplasma der Leberzelle gut korrelieren.
    Notes: Summary The template-activity of chromatin isolated from liver nuclei of developing rats increases sharply at birth and decreases remarkable until the 10th day. Between the 10th and the 40th day a slow increase was shown in template activity of chromatin tested with purified E.-coli RNA-polymerase (EC 2.7.7.6). We correlated these findings with changes of RNA-polymerase III-activity in rat liver during development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01470932
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    Paper (German National Licenses)
    Fulltext
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