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  • 1
    Electronic Resource
    Electronic Resource
    The extracellular matrix of theDictyostelium discoideum slug (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 1189-1196 
    Details
    ISSN: 1420-9071
    Keywords: Dictyostelium discoideum ; extracellular matrix ; cellulose ; cell-ECM interactions ; slime ; glycoproteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In this review, we detail the current understanding of the extracellular matrix (ECM) of the migratory slug phase of the cellular slime mould,Dictyostelium discoideum. We describe some structural and non-structural molecules which comprise the ECM, and how these molecules reflect both plant and animal ECM systems. We also describe zones of the multicellular slug that are known to make ECM components, including the role of the prestalk cells and the slug epithelium-like layer. Finally, we review the contributions of studies on mutant to our understanding of the ECM ofD. discoideum, and relate this to differentiation and development in more complex eukaryotic systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944736
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The cardiac effects of terfenadine after inhibition of its metabolism by grapefruit juice (1997)
    Springer
    European journal of clinical pharmacology 52 (1997), S. 311-315 
    Details
    ISSN: 1432-1041
    Keywords: Key wordsTerfenadine ; Grapefruit juice ; QT interval
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: To determine whether the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine are affected by the concomitant administration of grapefruit juice. Methods: Six healthy volunteers were recruited for a balanced cross-over study. Each volunteer received 120 mg terfenadine 30 min after drinking 300 ml of either water or freshly squeezed grapefruit juice. The alternative treatment was administered on the second study day 2 weeks later. Measurements of the area under the terfenadine plasma concentration-time curve (AUC), maximum terfenadine concentration (Cmax) and the time to maximum concentration (tmax) were made, and the corrected QT (QTc) interval was measured from the surface electrocardiogram. Results: Terfenadine was quantifiable in plasma in all 6 subjects on both study days for up to 24 h post-dosing. The AUC of terfenadine was significantly increased by concomitant grapefruit administration (median values 40.6 vs 16.3 ng · ml−1 · h), as was the Cmax (median values 7.2 vs 2.1 ng · ml−1). The tmax was not significantly increased and there was no significant change in the median QTc interval despite the increased terfenadine levels. The 95% confidence interval for the difference in the change in QTc interval at Cmax was −13 to +38 ms. Conclusion: Administration of grapefruit juice concomitantly with terfenadine may lead to an increase in terfenadine bioavailability, but the increase observed in this study did not lead to significant cardiotoxicity in normal subjects. However, this does not exclude the risk of cardiotoxicity in high-risk subjects given greater doses of grapefruit juice over longer periods of time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050296
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  • 3
    Electronic Resource
    Electronic Resource
    Separate and combined effects of nadolol and nifedipine on the cardiac response to exercise (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 113-117 
    Details
    ISSN: 1432-1041
    Keywords: nadolol ; nifedipine ; tachycardia ; cardiovascular response ; healthy volunteers ; pharmacokinetics ; exercise heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a placebo controlled exercise protocol using healthy volunteers the effects of nadolol 80 mg and 160 mg orally and of nadolol 80 mg during treatment with nifedipine 20 mg 8 hourly were compared. Resting systolic and diastolic blood pressures were reduced by both nifedipine (p〈0.05) and nadolol (p〈0.01) acting alone. An unexpected finding was that nifedipine alone significantly inhibited exercise tachycardia (p〈0.01) (8 to 12 h post dose). Predictably both doses of nadolol produced significant reduction in exercise tachycardia which was still apparent at 24 h. There was a linear relationship between log10 plasma nadolol concentration and reduction in exercise heart rate. The combined inhibitory effects of nifedipine and nadolol 80 mg on exercise heart rate showed partial additivity but did not summate. There was no pharmacokinetic interaction between the 2 drugs. The inhibition of exercise tachycardia by nifedipine, not previously documented, is consistent with an effect of the drug on the sinus node, as has been reported in in-vitro studies, and may contribute to the drugs efficacy in angina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609676
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetic interactions between felodipine and metoprolol (1987)
    Springer
    European journal of clinical pharmacology 31 (1987), S. 575-578 
    Details
    ISSN: 1432-1041
    Keywords: felodipine ; metoprolol ; pharmacokinetics ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary This double-blind, cross-over study in healthy male subjects evaluated the pharmacokinetics of felodipine and metoprolol given both separately and in combination. During three, five-day study periods, felodipine 10 mg b.d., metoprolol 100 mg b.d. and a combination of the two, were given in random order. There was at least a 7-day washout period between each pharmacokinetic study day. Plasma levels of unchanged felodipine and metoprolol were measured for 24 h after the last dose, on the 5th day of each treatment period. Eight subjects, aged 19–22 years, completed the study. Both felodipine and metoprolol, given alone and in combination, were well tolerated. None of the felodipine pharmacokinetic variables (tmax, Cmax, Cmin, AUC (0–12) and t1/2) changed significantly when felodipine and metoprolol were given in combination. Cmax and AUC (0–12) for metoprolol increased significantly when metoprolol and felodipine were combined, although tmax, Cmin and t1/2 for metoprolol remained unchanged. The changes in metoprolol pharmacokinetics induced by felodipine are small and unlikely to be clinically important.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606633
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  • 5
    Electronic Resource
    Electronic Resource
    Variability of plasma drug concentrations: Some observations (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 569-570 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542131
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  • 6
    Electronic Resource
    Electronic Resource
    Twelve hour (trough) plasma nifedipine concentrations during chronic treatment with nifedipine retard (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 347-349 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; plasma concentrations ; distribution ; debrisoquine phenotype ; retard preparation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Variations in plasma nifedipine concentrations have been reported and one study has suggested the existence of a subpopulation of poor metabolisers of this drug. We have studied the variability of 12 h plasma nifedipine concentrations in 64 hypertensive patients on long-term nifedipine Retard 20 mg twice daily. A slightly skewed unimodal distribution with a modal concentration of 15 to 30 ng/ml was obtained. No relationship between 12-h plasma levels and debrisoquine hydroxylation phenotype was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543967
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    A comparison of the effects of the selective peripheralα 1-blocker terazosin with the selectiveβ 1-blocker atenolol on blood pressure, exercise performance and the lipid profile in mild-to-moderate essential hypertension (1992)
    Springer
    Clinical autonomic research 2 (1992), S. 373-381 
    Details
    ISSN: 1619-1560
    Keywords: Selectiveα-blocker ; Selectiveβ-blocker ; Blood pressure ; Lipids ; Exercise ; Essential hypertension ; Clinical trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of six weeks of treatment with the selective peripheralα 1-adrenoceptor blocker terazosin, or the selectiveβ 1-adrenoceptor blocker atenolol on blood pressure, exercise performance and blood lipid profile were compared in a single-blind, randomized, crossover study of 17 patients with mild-to-moderate essential hypertension. Although both drugs significantly reduced blood pressure at rest, atenolol caused a larger fall in supine blood pressure (11/11 and 7.5/7.0 mmHg, atenolol and terazosin, respectively;p 〈 0.001). Both treatments controlled the pressor response to exercise, although a greater reduction in diastolic blood pressure was observed at the end of exercise on terazosin (74.0 ± 5.7 and 91.6 ± 4.0 mmHg, terazosin and atenolol, respectively;p 〈 0.01). Alpha1-blocker therapy was not associated with any measurable improvement or deterioration in cardiopulmonary performance and exercise duration. Unlike atenolol, terazosin therapy had the potentially beneficial effect of reducing serum total cholesterol levels and increasing the high-density lipoprotein-cholesterol/low-density lipoprotein-cholesterol ratio.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01831394
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