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  • 1
    Electronic Resource
    Electronic Resource
    Paraneoplastic hypokalemia in acute myeloid leukemia: a case of renin activity in AML blast cells (1996)
    Springer
    Annals of hematology 73 (1996), S. 139-141 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute myeloid leukemia ; Hypokalemia ; Renin ; Aldosteronism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Hypokalemia due to renal potassium loss has frequently been observed in patients with acute myeloid leukemia (AML). The pathogenic mechanism for this hyperkaluresis is unclear. In this report we describe a patient with AML FAB M4, in whom the clinical course, the electrolyte disturbances, the serum aldosterone levels, and the diffuse hyperplasia of the adrenal cortex documented a typical case of marked secondary hyperaldosteronism. On analysis of the leukemic cells of this patient compared with normal bone marrow cells, a significant increase of renin-like activity in the cytosol of the blast cells was noted. Activation of the renin-angiotensin-aldosterone system by paraneoplastic production of renin-like activity in AML blast cells might contribute to the hypokalemia often observed in patients with acute myeloid leukemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050215
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Plasmacytosis in acute myeloid leukemia: two cases of plasmacytosis and increased IL-6 production in the AML blast cells (1998)
    Springer
    Annals of hematology 76 (1998), S. 273-277 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute myeloid leukemia ; Plasmacytosis IL-6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  An increased plasma cell count in the bone marrow occurs in a subgroup of patients with acute myeloid leukemia (AML). The pathogenic mechanism for this plasmacytosis is unclear. In this report we describe two patients with AML and plasmacytosis who shared some features of their diseases. The morphological subtypes were AML M4 and M4eo; the leukemias were secondary to cytotoxic pretreatment, and complex cytogenetic changes were found in the leukemic cells of both patients. There was a marked increase in the number of bone marrow plasma cells in both cases and no monoclonal immunoglobulin was detectable. The IgH-CDR3 gene scan depicted a monoclonal IgH rearrangement in the bone marrow cells of one patient. Analysis of the cytokine production of the leukemic cells showed a high production of IL-6 of the leukemic blast cells in the in vitro cell culture and a high cytoplasmic IL-6 in the leukemic cells as revealed by immunocytology. We describe the clinical picture of a type of secondary AML with FAB M4 morphology associated with bone marrow plasmacytosis. We suggest that paracrine growth stimulation of plasma cells by paraneoplastic IL-6 production of the leukemic blast cells contributes to the plasmacytosis observed in patients with AML.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050401
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Sensitiver Nachweis disseminierter Tumorzellen – Prognostische Bedeutung und Therapieansätze (1997)
    Springer
    Der Internist 38 (1997), S. 1083-1091 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Mikrometastasen ; Minimal Residual Disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Während der Nachweis von disseminierten Tumorzellen von erheblicher prognostischer Bedeutung ist, sind die Konsequenzen aus diesen Beobachtungen bisher für die Therapie nur bedingt verwertbar. Denkbar sind neue Strategien bei minimaler Tumorlast, z.B. bei Patientinnen mit Mammakarzinom nach erfolgreicher Primärbehandlung. Die frühzeitige Rezidivbehandlung profitiert ebenfalls vom Nachweis niedriger Tumorlast, nachgewiesen für Patienten mit chronischer myeloischer Leukämie und akuter Promyelozytenleukämie. Die modernen Möglichkeiten, disseminierte Tumorzellen als Ausdruck einer minimalen Resterkrankung festzustellen, sind eine wichtige Bereicherung für das Staging, die Prognose, die Therapie und zugleich das Verständnis maligner Erkrankungen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050121
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    Paper (German National Licenses)
    Fulltext
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