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  • 1
    Electronic Resource
    Electronic Resource
    Blockade of superoxide generation prevents high-affinity immunoglobulin E receptor-mediated release of allergic mediators by rat mast cell line and human basophils (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Previous studies have shown that rat peritoneal mast cells and mast cell model rat basophilic leukaemia (RBL-2H3) cells generate intracellular reactive oxygen species (ROS) in response to antigen challenge. However, the physiological significance of the burst of ROS is poorly understood.Objective The present study was undertaken to investigate the role of superoxide anion in mediator release in rat and human cell systems.Methods RBL-2H3 cells were directly stimulated with anti-rat FcεRI α-subunit monoclonal antibody (mAb). For the analysis of human cell system, leucocytes were isolated by dextran sedimentation from healthy volunteers or from patients, and challenged either with anti-human FcεRI mAb or with the relevant antigens. Superoxide generation was determined by chemiluminescence-based methods. The releases of histamine and leukotrienes (LT)s were determined by enzyme-linked immunosorben assay (ELISA).Results Cross-linking of FcεRI on RBL-2H3 cells or on human leucocytes from healthy donors by the anti-FcεRI mAb resulted in a rapid generation of superoxide anion, as determined by chemiluminescence using superoxide-specific probes. Similarly, leucocytes from patients generated superoxide anion in response to the challenge with the relevant allergen but not with the irrelevant allergen. Furthermore, diphenyleneiodonium (DPI), a well-known inhibitor of flavoenzymes suppressed the superoxide generation and the release of histamine and LTC4 induced by the anti-FcεRI mAb or by allergen in parallel.Conclusion These results indicate that both RBL-2H3 cells and human basophils generate superoxide anion upon FcεRI cross-linking either by antibody or by allergen challenge and that blockade of the generation prevents the release of allergic mediators. The findings strongly support the role of superoxide generation in the activation of mast cells and basophils under both physiological and pathological conditions. The findings suggest that drugs regulating the superoxide generation have potential therapeutic use for allergic disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0954-7894.2002.01263.x
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  • 2
    Electronic Resource
    Electronic Resource
    Radiopacity of 12 visible-light-cured dental composite resins (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 20 (1993), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The radiopacity of 12 VL-cured composite resins was determined with reference to an aluminum step-wedge. Two anterior composites were radiolucent while two anterior and one anterior/posterior composites exhibited the radiopacity equal to, or slightly greater than, that of human enamel. Three posterior and one inlay composites possessed the radiopacity equivalent to, or in tiny excess of, that of human enamel. Three posterior composites had the radiopacity, fairly exceeding that of human enamel. Chemical analyses of the filler particles were carried out with SEM/EDX. It became evident that radiopaque fillers contained at least one radiopaque oxide component such as BaO, ZrO2 and Yb2O3 with varying concentrations. In general, the radiopacity of the composite resin was linearly proportional to the amount of the radiopaque oxide in the filler. It was suggested that ZrO2 was radiopacifier equivalent to, or even stronger than, BaO.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1993.tb01648.x
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  • 3
    Electronic Resource
    Electronic Resource
    In-vitro and in-vivo wear profile of composite resins (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 19 (1992), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to evaluate in-vitro wear by two types of slurry of 10 commercial composite resin materials (seven hybrid and three microfilled composites). There was great variation in the in-vitro wear pattern by two types of slurry. The wear rate of microfilled composites was greater than that of hybrid composites, and a negative correlation was observed between wear rate and Knoop hardness values among all materials when hydroxyapatite slurry was used. In contrast, the wear rate of hybrid composites was greater than that of microfilled composites when abraded by green carborundum slurry. These abraded surfaces were compared with SEM micrographs of in-vivo composites surface after 4 years of service. The profile of in-vivo wear surfaces was found to be similar to that of in-vitro wear surfaces abraded with hydroxyapatite slurry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1992.tb01588.x
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  • 4
    Electronic Resource
    Electronic Resource
    Dental cutting behaviour of mica-based and apatite-based machinable glass-ceramics (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 17 (1990), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Some recently developed industrial ceramics have excellent machinability properties. The objective of this study was to evaluate the dental cutting behaviour of two machinable glass-ceramics, mica-containing Macor-M® and apatite- and diopsidecontaining Bioram-M®, and to compare them with the cutting behaviour of a composite resin typodont tooth enamel and bovine enamel. Weight-load cutting tests were conducted, using a diamond point driven by an air-turbine handpiece. While the transverse load applied on the point was varied, the handpiece speed during cutting and the volume of removal upon cutting were measured. In general, an increase in the applied load caused a decrease in cutting speed and an increase in cutting volume. However, the intensity of this trend was found to differ between four workpieces. Cutting Macor-M® resulted in the second-most reduced cutting speed and the maximum cutting volume. Cutting Bioram-M® gave the least reduced cutting speed and the minimum cutting volume. It was suggested that two machinable glass-ceramics could be employed as typodont teeth. This study may also contribute to the development of new restorative dental ceramic materials, prepared by machining.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1990.tb01417.x
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  • 5
    Electronic Resource
    Electronic Resource
    Thermal behavior of casting investment during setting (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 22 (1995), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY The aim of this study was to examine the thermal reactions of silica-sol liquids for mixing investment powders using differential thermal analysis (DTA) and also the setting behaviour of the mixed powders using differential scanning calorimetry (DSC). The silica-sol liquids showed the appearance of vapourization (around 100°C as a peak temperature) and combustion (200–300°C) in DTA measurement. Mixed silica-sol investment exhibited the setting behaviour with an exotherm in the DSC measurement representing that greater peak time, setting time and heat in mixed investment than with gypsum-bonded investment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1995.tb00787.x
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  • 6
    Electronic Resource
    Electronic Resource
    Studies on fracture toughness of dental ceramics (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 17 (1990), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: One important mechanical property of dental ceramics is fracture toughness, KIC, which represents the serviceability in the oral cavity, such as the resistance to marginal fracture. KIC values of several dental ceramics, natural tooth enamel and industrial ceramics were examined by use of the indentation microfracture (IM) method. This technique was based on the series of radial cracks emanating from the corners of the Vickers indentation. It was observed that appropriate load levels should be selected on each specimen to induce radial/median cracks. For feldspatic dental porcelains, larger loads of 10, 20 and 30 kg were needed to determine their KIC values in the range 1.5–2.1 MN-rn−3/2. For natural tooth enamel and a new apatite-based castable glass-ceramic, a smaller force of 1 kg was sufficient to decide the respective KIC values of about 0.9 and 1.8 MN-m−3/2. The KIC values of most dental ceramics examined were slightly higher than that of soda lime glass, but less than one-third that of zirconia. It was confirmed that the IM method is simple and cost-effective for evaluation of KIC of dental ceramics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1990.tb01426.x
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  • 7
    Electronic Resource
    Electronic Resource
    Residual monomers (TEGDMA and Bis-GMA) of a set visible-light-cured dental composite resin when immersed in water (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 18 (1991), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Rods of a visible-light-cured dental composite resin were photo-polymerized and immersed in water at 37°C for 7 days. The residual monomers (TEGDMA and Bis- GMA) trapped in the set composite and those eluted into water were analysed by gas-liquid chromatography. It became evident that minor amounts of the residual monomers dissolved in water, but that most residual monomers remained in the set composite. Extension of the irradiation period contributed to the significant reduction in the residual monomer level and its elution into water.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1991.tb00067.x
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  • 8
    Electronic Resource
    Electronic Resource
    Studies on dental high-speed cutting of commercial pure titanium (Ti) and free-machining titanium (DT-2F) (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 24 (1997), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary Some dental prostheses are formed by machining. The purpose of this study was to evaluate the dental high-speed cutting behaviour of free-machining titanium (Ti), the ease in cutting of which is metallurgically improved. Weight-load cutting tests were performed on commercial pure Ti and free-machining Ti, using a diamond point and a carbide burr. It became evident that the cutting effectiveness of two rotary cutting instruments on free-machining Ti was superior to that on commercial pure Ti due to the formation of accelerated cut debris. Cutting of free-machining Ti resulted in less damage of the carbide burr, compared with the cutting of commercial pure Ti. These results suggest that free-machining Ti is a suitable workpiece for dental Ti-based machined prostheses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1997.tb00369.x
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Cutting effectiveness of diamond points on commercial core composite resins and cements (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 23 (1996), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary In dental clinics, composite resin and cement cores are routinely cut and polished during abutment tooth preparation. To identify their characteristics during cutting, weight-load cutting tests were performed on eight commercial core composites and two cements, using diamond points driven by an air-turbine handpiece. It became evident that the cutting effectiveness of the diamond points on nine workpieces exceeded that on natural tooth dentine, while that on one composite containing Si3N4 filler was analogous to that on dentine. With continued use, the cutting effectiveness of the diamond point on all workpieces gradually declined. SEM observations revealed that diamond particles of the diamond point wore out with repeated use. It is clinically advised to select the core material with material characteristics during cutting and mechanical strength similar to those of dentin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1996.tb00872.x
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  • 10
    Electronic Resource
    Electronic Resource
    Hardness and fracture toughness of four commercial visible light-cured composite resin veneering materials (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 22 (1995), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary Four commercial visible light (VL)-cured composite resin veneering materials with a dentine shade were examined for their Knoop hardness and fracture toughness. Composite specimens were classified into three groups. The first group was cured by VL only, the second group was cured by VL and postcured by VL and the third group was cured by VL and post-cured by heat. It became evident that one composite containing four-functional urethane monomer had both hardness and fracture toughness greater than those of the other three composites containing two-functional urethane monomer. The filler content (vol%) in the composite tended to be linearly proportional to both hardness and fracture toughness. Post-curing by VL and heat were proven to effectively increase both hardness and fracture toughness of once light-cured composites. These results suggest that the clinical performance (e.g. wear resistance and colour stability) of VL-cured composite resin veneering materials might be improved with the aid of post-curing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1995.tb00234.x
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