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  • 1
    Electronic Resource
    Electronic Resource
    Osteocalcin-directed gene therapy for prostate-cancer bone metastasis (2000)
    Springer
    World journal of urology 18 (2000), S. 102-110 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Osteocalcin (OC) is a major noncollagenous bone protein whose expression is limited almost exclusively to osteotropic tumors and mature calcified tissue (differentiated osteoblasts). The function of OC, a highly conserved gamma-carboxyglutamic acid-containing protein, relies in part on its ability to bind hydroxyapatite and act as a chemoattractant for bone-resorbing cells. Serum osteocalcin levels are used clinically as an index of active bone turnover. Research in our laboratory has revealed that OC is expressed in several solid tumors, including osteosarcoma and ovarian, lung, brain, and prostate cancers. Evidence arising from reverse-transcription polymerase chain reaction (RT-PCR; detection of OC mRNA), immunohistochemical staining (detection of OC protein), and transient transfection and reporter assay (detection of OC mRNA transcription) reveals that OC expression is up-regulated in numerous solid tumors, with its expression being further elevated in androgen-independent prostate cancers. A recombinant, replication-defective adenovirus, Ad-OC-TK (OC promoter-driven herpes-simplex-virus thymidine kinase) was constructed and, when combined with the appropriate prodrug, either ganciclovir (GCV) or acyclovir (ACV), was found to be effective at destroying prostate-cancer cell lines in vitro and prostate tumor xenografts in vivo in both subcutaneous and bone sites. Additionally, via use of the OC promoter the supporting bone stromal cells are cotargeted when the prostate cancer interdigitates with bone stroma at the metastatic skeletal sites. Thus, maximal tissue-specific cell toxicity is achieved by the interruption of cellular communication between the prostate cancer and the bone stroma. We describe herein the preclinical foundation as well as the design and implementation of an ongoing phase I clinical trial at the University of Virginia that targets androgen-independent metastatic prostate cancer using the Ad-OC-TK vector.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003450050181
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  • 2
    Electronic Resource
    Electronic Resource
    IgG subclass/IgM ratio and response to therapy in focal segmental glomerulosclerosis (1998)
    Springer
    Pediatric nephrology 12 (1998), S. 761-763 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Focal segmental glomerulosclerosis ; Immunoglobulin ; Nephrotic syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Focal segmental glomerulosclerosis (FSGS) is relatively steroid resistant and no clinical or histological marker can predict the response to therapy. To investigate the role of serum immunoglobulin subclass/IgM in predicting the response to therapy in FSGS, serum concentrations of total IgG, IgG subclasses, and the ratio of serum IgG subclasses to total IgG (% IgG subclass) were measured in 27 children during the acute nephrotic state. Prednisolone, cyclophosphamide, and Persantine (dipyridamole) were given for 12 weeks. We divided the patients into good responders or poor responders according to clinical response. The clinical and nephrotic status were similar in both groups. Fourteen patients were good responders with higher serum IgG1/IgM than that of non-responders (4.00±0.67 vs. 1.61±0.20, P〈0.05). There was no significant difference in IgG2/IgM between these two groups. These results suggest that higher serum IgG1/IgM ratios may be associated with a better clinical response. These changes may reflect dysregulation of immunoglobulin class switching in patients with FSGS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050541
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  • 3
    Electronic Resource
    Electronic Resource
    Lupus nephritis in children — a review of 167 patients (1995)
    Springer
    Pediatric nephrology 9 (1995), S. 573-573 
    Details
    ISSN: 1432-198X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00860937
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  • 4
    Electronic Resource
    Electronic Resource
    Numerical simulation of semicrystalline polymer flowing in an empty tube with solidification (1992)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 32 (1992), S. 724-731 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A methodology is set forth for the numerical solution of the transient freezing problem of a viscous power-law fluid flowing in a cold empty tube with a frozen layer forming on the inside tube surface. The fluid considered is the melt of a semicrystalline polymer with temperature dependent viscosity. The solution domain encompasses both the liquid and solid phases. Coordinate transformations are employed to immobilize and to straighten the moving, curved interface. An implicit finite difference method is employed to solve the governing equations. Numerical results are analyzed by examining the effects of the Peclet number, Nahme number, Stefen number, and the power law index on the profiles of the frozen layer. Variations of the thickness of the frozen layer as a function of time and axial coordinate are also presented.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760321104
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  • 5
    Electronic Resource
    Electronic Resource
    Steady solidification of non-Newtonian fluid flowing in a round tube (1991)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 31 (1991), S. 191-196 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The problem of steady solidification of a power law fluid flowing in a round tube was solved numerically. The fluid considered was a polymer with temperature dependent viscosity. The mathematical solution was obtained by using an implicit finite difference method. Results are presented to show the effects of the Peclet number, Nahme number, and the power law index on the profiles of the frozen layer. Melt temperature profiles at different axial locations are also presented.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760310306
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    Paper (German National Licenses)
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