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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 143 (2000), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 51 (1983), S. 341-345 
    ISSN: 1432-1246
    Keywords: Occupational leukoderma ; 4-tertiary butyl catechol ; Glutathione reductase ; Pheomelanogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of 4-tertiary butyl catechol (TBC), a potent depigmenting chemical, on glutathione reductase (GR) in pigmented ear skin of hairless mice was investigated. Three topical applications of TBC, which cause neither skin color changes nor melanocyte degeneration, induced an increase in enzyme activity. Since the same treatment resulted in pheomelanin formation as evidenced by electron microscopy, it is suggested that the GR increase correlates at least in part with changes in melanocyte metabolism. This enzyme generates a reduced form of glutathione which may be involved in the formation of glutathionedopas, substrates for hydrolytic enzymes to produce cysteinyldopas, and pheomelanin. Elevation of GR may be an indication of melanogenesis before clinical skin color changes due to TBC appear. It may be used for the early detection of occupational leukoderma.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé On a effectué l'examen histologique de 15 échantillons biopsiques du tissu de régénération cartilagineux de la surface d'appui de l'articulation de la hanche. Ces échantillons ont été prélevés sur 15 malades qui avaient subi avec succès une ostéotomie de valgisation fémorale. Chez 6 des ces 15 patients, les 3 couches du tissu de régénération étaient fortement colorées par la safranine O. Cependant, chez 6 autres patients, cette coloration n'était observée que dans les couches intermédiaires et profondes, tandis que, chez 2 patients, seule la couche profonde était colorée. Une immuno-histochimie pratiquée avec la protéine S-100 sur 5 échantillons a permis le marquage de toutes les cellules. Ceci a montré que les cellules du tissu de régénération étaient des chondrocytes. Cependant il n'y avait pas de ligne d'ossification dans le tissu de régénération et l'agencement des cellules différait de celui d'un cartilage normal. On a noté également une discontinuité de l'os sous-chondral. Ces résultats indiquent qu'il est trés probable que le tissu de régénération soit d'origine médullaire.
    Notes: Summary In this study biopsy specimens of the surface repair tissue from the weightbearing area of the hip joint were collected from 15 patients who had undergone successful valgus osteotomy, and these were examined histologically. In 6 of the 15 patients the specimens stained strongly with safranin-O in all three layers of the matrix. However, the repair tissue from another 6 patients showed strong staining only in the intermediate and deep layers, while that from 2 patients stained only in the deep layer. Specimens from 5 patients were stained for S-100 protein and positive cells were detected in all cases, demonstrating that the cells in the repair tissue were chondrocytes. However, there was no tide mark in the repair tissue and the arrangement of the cells differed from that in normal cartilage. Discontinuity of the subchondral bone was also noted. These findings make it likely that the repair tissue was of bone marrow origin.
    Type of Medium: Electronic Resource
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