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  • 1
    Electronic Resource
    Electronic Resource
    Human muscle spindles: fine structure of the primary sensory ending (1975)
    Springer
    Journal of neurocytology 4 (1975), S. 675-695 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The primary sensory innervation of muscle spindles obtained by muscle biopsy of normal human volunteers was studied with the light and electron microscopes. The parent IA sensory fibre branched 4–6 times, became unmyelinated for 25–30 μm, then formed sensory terminals on each nuclear bag and chain intrafusal muscle fibre. The first 4–5 μm of the unmyelinated segment is believed to be an encoder zone because the plasmalemma was undercoated by a dense granular layer similar to that under other membranes where action potentials originate. A reconstruction from micrographs of serial longitudinal sections showed that the primary sensory ending on a nuclear bag fibre is an irregular coil with branches and varicose swellings. The terminals contain central aggregates of microfilaments often surrounded by mitochondria, small numbers of vesicles, cisterns and tubular profiles. The latter merge with the plasma membrane. Junctional complexes between the plasma membranes of the terminals and intrafusal muscle resemble fascia adherns and are postulated to act as attachment plaques. These could contribute to the transduction process by increasing the degree of distortion of the terminal's membrane when stretch is applied to the spindle. A mechanism is described which could account for some of the differences in sensitivity of the primary and secondary sensory endings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01181630
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Human muscle spindles: Microfilaments in the group IA sensory nerve endingsSupported in part by a grant from the ALS Foundation, St. Paul, Minnesota. (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 180 (1974), S. 521-532 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The fine structure of the group IA sensory nerve endings from normal human muscle spindles was studied in transverse and longitudinal sections. Two arrangements of microfilaments, approximately 75 Å in diameter, were found in each of ten spindles examined. The first was a central aggregate of densely packed filaments. The aggregates were partly surrounded by mitochondria, and were oriented parallel to the longitudinal axis of the sensory ending as it encircled the intrafusal muscle fiber. Individual aggregate filaments of glycerinated endings appeared to react with heavy meromyosin. The second arrangement was a filamentous network in the periphery of the sensory ending profiles. These microfilaments approached and appeared to merge with the surface membrane. They resembled the microfilaments that others have described in growth cones of cultured neurons. Both types of microfilaments are thought to be involved in changing the shape of the sensory endings during stretch and relaxation of the spindle.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091800311
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    Paper (German National Licenses)
    Fulltext
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