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  • 1
    Electronic Resource
    Electronic Resource
    Theoretical conformational analysis of disulfide-linked tetrapeptides Ac-Cys-Pro-D-Xaa-Cys-NHMe having hydrophobic D-Xaa amino-acid residues (1998)
    Springer
    Polymer bulletin 41 (1998), S. 623-629 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary Theoretical conformational analysis was carried out for four disulfide-linked tetrapeptides Ac-Cys-Pro-D-Xaa-Cys-NHMe(D-Xaa= D-Val, D-Phe, D-Leu, and D-norleucine) using ECEPP and optimization procedure for investigating how the stabilities of the β-bend conformation at D-Xaa-Pro portion are affected by branching and bulkiness of hydrophobic side-chain groups of D-Xaa residue. Calculated results indicate that cyclic Ac-Cys-Pro-D-Xaa-Cys-NHMe commonly have a dominant character taking type II β-bend at the Pro-D-Xaa portion and also show fairly good agreement with experimental results of the NMR spectroscopy for a tetrapeptide Ac-Cys-Pro-D-Val-Cys-NH2. It is shown that the Ala-residue approximation is also a reasonable method to investigate the basic local conformational character of the Cys-Pro-D-Xaa-Cys sequence as well as that of the Cys-Pro-Xaa-Cys one. Moreover, it is suggested that the disulfide-linked tetrapeptides Ac-Cys-Pro-D-Xaa-Cys-NHMe are good candidates of the simple standard molecules for investigating the spectroscopic characters related to type II β-bend conformations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002890050410
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  • 2
    Electronic Resource
    Electronic Resource
    Prophylactic intravesical instillation therapy with adriamycin and mitomycin C in patients with superficial bladder cancer (1987)
    Springer
    Cancer chemotherapy and pharmacology 20 (1987), S. S72 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intravesical instillation of adriamycin (ADM) or mitomycin C (MMC) was carried out for the purpose of preventing the recurrence of superficial bladder cancers (Ta and T1) after transurethral resection or transurethral coagulation. First, eligible patients were divided into two groups (solitary and multiple) and then they were randomized into the following three groups: (1) ADM group, intravesical instillation with 50 mg ADM dissolved in 100 ml physiological saline; (2) MMC group, intravesical instillation with 30 mg MMC dissolved in 100 ml physiological saline; (3) control, transurethral resection or transurethral coagulation alone. The drugs were given six times by instillation within 2 weeks after TUR or TUC; after 2 weeks the drugs were administered for 2 consecutive days every 4 weeks for 2 years. Of the 134 patients admitted to the study, 103 were evaluable and 31 were eliminated as non-evaluable patients. The cumulative nonrecurrence rates were 73.6% for ADM, 63.4% for MMC, and 22.5% for controls after a follow-up of 24 months. The cumulative non recurrence rates of the ADM and MMC groups were significantly higher than that of the control group. The incidence of side effects was low and the grade of these side effects mild. This instillation therapy with ADM and MMC was considered useful for preventing the recurrence of superficial bladder cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262491
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  • 3
    Electronic Resource
    Electronic Resource
    Intravesical treatment of bladder cancer with recombinant human interferon-β (1989)
    Springer
    Cancer immunology immunotherapy 30 (1989), S. 81-85 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to examine its clinical efficacy, recombinant human interferon-β (rIFN-β) was instilled intravesically into 51 patients with superficial bladder cancer. Ten patients, who received intermittent intravesical instillation at a dose of (3−36) × 106 U rIFN-β on days 1–3 every week, showed no response. Thirty-two patients received intravesical instillation at a dose of (3−36) × 106 U every day for 10–20 days. Eight patients showed partial response, indicating an efficacy rate of 25%. Nine patients received divided doses of 18 × 106 U twice a day every day for 10–20 days. Six patients showed partial response, indicating an efficacy rate of 67%. This value was significantly higher than that obtained by administering divided doses. The response to intravesical instillation therapy with rIFN-β varies with treatment protocol. Frequent and longer exposure to rIFN-β may induce better regression of superficial bladder cancer. Six incidences of side-effects were found in five cases (9.8%): pollakiuria in one, pain on micturition in two, fever in two, and eruption in one case. All of these side-effects were slight and reversible after drug withdrawal. Laboratory tests showed only a few changes with low severity. Thus, rIFN-β is potentially a new drug for instillation therapy of superficial bladder cancer, in view of the absence of adverse effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01665957
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  • 4
    Electronic Resource
    Electronic Resource
    Intravesical chemotherapy with 4′-epi-Adriamycin in patients with superficial bladder tumors (1986)
    Springer
    Cancer chemotherapy and pharmacology 16 (1986), S. 176-177 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We evaluated the effects of 4′-epi-Adriamycin (EPI), a derivative of Adriamycin (ADR), in intravesical instillation chemotherapy. The patients received two courses of three daily instillations of 50–80 mg EPI dissolved in 30 ml physiological saline on 3 consecutive days, with an interval of 4 days between courses. Full evaluation was possible in 33 of 35 patients with superficial bladder tumors treated with EPI. Complete response was observed in 4 cases and partial response in 14 cases, giving a response rate of 55%. Side effects such as pollakiuria and pain on micturition occurred in 9 cases. EPI appears to be an effective agent for intravesical instillation chemotherapy in patients with superficial bladder tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256171
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  • 5
    Electronic Resource
    Electronic Resource
    Development of Anti-Influenza Virus Drugs I: Improvement of Oral Absorption and In Vivo Anti-Influenza Activity of Stachyflin and Its Derivatives (1999)
    Springer
    Pharmaceutical research 16 (1999), S. 1041-1046 
    Details
    ISSN: 1573-904X
    Keywords: influenza ; oral absorption ; PEG ; phosphate ester prodrug ; anti-influenza virus drug
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. Stachyflin and its derivatives which are active against the influenza virus in vitro, were studied to improve their reduced in vivo activity after oral administration by chemical modification and some vehicles. Methods. The solubility was examined for different vehicles. The improvement of gastrointestinal absorption was evaluated by the plasma concentration after oral administration to mice or the in situ loop method with rats. The in vivo anti-influenza activity was examined using mice infected with the influenza virus and evaluated based on the virus titer in the lung by TCID50. Results. PEG 400 showed the highest solubility of Stachyflin and its derivative among the vehicles studied. While no viral inhibition was found in the lung after oral administration of 0.5% HPMC suspension of Stachyflin, in vivo anti-influenza virus activity was found with the PEG 400 solution. The absorption of Stachyflin by PEG 400 showed about a fifty-fold increase in AUC compared with that of 0.5% HPMC suspension. Improving the oral absorption of Stachyflin led to an increase in the in vivo anti-influenza virus activity. When the Stachyflin derivative in PEG 4000 was administered orally, there was more enhancement of the oral absorption than with PEG 400. When the aqueous solution of the phosphate ester prodrugs of Stachyflin and its derivative was administered orally, the absorption of the parent compound was improved and in vivo anti-influenza virus activity was found. Conclusions. When Stachyflin and its derivatives were administered orally to mice with a solution in PEG and an aqueous solution of their phosphate ester, their oral absorption was improved and in vivo anti-influenza virus activity was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018983715982
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  • 6
    Electronic Resource
    Electronic Resource
    Theoretical conformational analysis of tetrapeptide Ac-Cys-Pro-Gly-Cys-NHMe with disulfide linkage (1997)
    Springer
    Polymer bulletin 38 (1997), S. 109-115 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. Theoretical conformational analysis was carried out for the acyclic and cyclic tetrapeptides Ac-Cys-Pro-Gly-Cys-NHMe using ECEPP and optimization procedure for investigating the conformational preference of peptides having disulfide linkage. Calculated results indicate that cyclic Ac-Cys-Pro-Gly-Cys-NHMe forms compactly fold conformations with type II β-bend at the Pro-Gly portion, and also show fairly good agreement with experimental results of the NMR spectroscopy for the tetrapeptides having Cys-Pro-Gly-Cys sequence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002890050026
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  • 7
    Electronic Resource
    Electronic Resource
    Theoretical conformational analysis of tetrapeptide Ac-Cys-Pro-Ala-Cys-NHMe with disulfide linkage (1997)
    Springer
    Polymer bulletin 38 (1997), S. 227-234 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. Theoretical conformational analysis was carried out for the acyclic and cyclic tetrapeptides Ac-Cys-Pro-Ala-Cys-NHMe using ECEPP and optimization procedure for investigating the conformational preference of peptides having disulfide linkage. Calculated results indicate that cyclic Ac-Cys-Pro-Ala-Cys-NHMe forms compactly fold conformations with type III-III double bend at the Pro-Ala-Ala portion, and also show fairly good agreement with experimental results of the NMR spectroscopy for the tetrapeptides having Cys-Pro-Ala-Cys sequence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002890050042
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  • 8
    Electronic Resource
    Electronic Resource
    Theoretical conformational analysis of tetrapeptide Ac-Cys-Pro-d-Ala-Cys-NHMe with disulfide linkage (1997)
    Springer
    Polymer bulletin 39 (1997), S. 377-384 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary. Theoretical conformational analysis was carried out for the acyclic and cyclic tetrapeptides Ac-Cys-Pro-d-Ala-Cys-NHMe using ECEPP and optimization procedure for investigating the conformational preference of peptides having disulfide linkage. Calculated results indicate that cyclic Ac-Cys-Pro-d-Ala-Cys-NHMe forms compactly fold conformations with type II β-bend at the Pro-d-Ala protion, and also show fairly good agreement with experimental results of the NMR spectroscopy for the tetrapeptides having Cys-Pro-d-Ala-Cys sequence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002890050162
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  • 9
    Electronic Resource
    Electronic Resource
    Comparative sequence analysis and expression of bovine PrP gene in mouse L-929 cells (1992)
    Springer
    Virus genes 6 (1992), S. 343-356 
    Details
    ISSN: 1572-994X
    Keywords: Bovine PrP ; cDNA ; nucleotide sequence ; gene expression ; transfection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A cDNA clone encoding bovine scrapie-associated fibril protein, PrP, from a bovine brain cDNA library and six amplified genomic DNA clones of bovine PrP were characterized. These clones possessed specific characteristics observed in other animal PrP genes. However, the bovine PrP was divided into two types by the number of repeats. One possessed four octapeptide repetitive sequences, like other animal PrP genes, and consisted of 256 amino acids; the other had five such repetitive sequences and 264 amino acids. The amino acid sequence of the former bovine PrP agreed with that of sheep PrP up to the 165th amino acid from the N-terminus. Bovine PrP cDNA introduced into mouse L-929 cells were stably expressed. The expression level of recombinant bovine PrP in the cells judged by immunofluorescence was higher than that of authentic mouse PrP. The recombinant PrP comigrated with authentic bovine PrP in SDS-polyacrylamide gel electrophoresis, suggesting that the recombinant product was fully glycosylated in L-929 cells. Distinct bundles of the intermediate filaments were frequently seen at the perinuclear region of the cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01703083
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