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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 189 (1989), S. 355-362 
    ISSN: 1433-8580
    Keywords: Ciclosporin ; Thyroid-stimulating immunoglobulins ; Endocrine orbitopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The study investigated whether ciclosporin (C) affected the thyroid-stimulating immunoglobulins (TSI) in serum of patients with endocrine orbitopathy (EO). The effect of C was compared with that of prednisone (P). Fifteen patients with EO classes III–V received C (n = 7) or P (n = 8). In addition to the immunosuppressants, five patients with Graves' disease in each group received methimazole (MMI). The stimulation of the cAMP levels in the medium of thyrocyte cultures was determined as a parameter of TSI. The TSI levels were markedly lowered in both groups during and after therapy. C group: before therapy 6.2 pmol/ml ± 1.63 (100%, mean ± SEM), during treatment 4.6 pmol/ml ± 2.28 (74%), after treatment 4.1 pmol/ml ± 1.33 (66%). P group: before treatment 9.1 pmol/ml ± 3.42 (100%), during treatment 5.9 pmol/ml ± 2.90 (65%), after treatment 3.7 pmol/ml ± 1.20 (41%). There is neither a significant difference between the two groups nor between the patients who received the combined therapy (MMI + immunosuppressants) or only received immunosuppressants (P more than 0.05). The mean cAMP value of the healthy reference group (n = 19) is 0.4 pmol/ml ± 0.03. There is a significant difference between this value and the cAMP values of the patients both before and after therapy (P less than 0.01). Thus, both C and P markedly lower the TSI titers of patients with EO.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 211 (1996), S. 85-91 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The two-dimensional angular correlation of annihilation radiation (2D-ACAR) technique has been developed to measure the hole structure of stretched and oriented polymers. The determination of polymer hole structure is demonstrated in a stretched semi-crystalline polyaryl-ether-ether-ketone (PEEK) sample. The atomic scale anisotropy is found to be consistent with the macroscopic scale stretch ratio. Applications of the 2D-ACAR method to image the three-dimensional hole, free-volume, and cavity structures of molecular systems are discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 33 (1995), S. 2365-2371 
    ISSN: 0887-6266
    Keywords: positron annihilation ; positronium ; free volume ; hole ; gas permeation ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Free-volume hole sizes, fractions, and distributions in a series of polycarbonate-based polymers are measured by using positron annihilation lifetime (PAL) spectroscopy. Correlations between the obtained free-volume hole properties and gas diffusion coefficients are observed. © 1995 John Wiley & Sons, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 36 (1998), S. 3049-3056 
    ISSN: 0887-6266
    Keywords: positron annihilation ; free volume ; polysulfone ; CO2 gas exposure ; Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Positron annihilation lifetime (PAL) spectroscopy has been employed to study subnanometer hole properties in polysulfone (PSF). In this study, hole properties of size, fraction, and distribution of PSF exposed to CO2 are reported. In the PSF/CO2 system, the hole size and fraction significantly increase and the free-volume distribution broadens as a function of CO2 pressure in the range of 0-1000 psi. Hysteresis in hole properties is observed during CO2 sorption/desorption cycle. The high sensitivity of PAL results due to CO2 exposure in PSF is explained in terms of the microstructural changes in the polymer matrix, i.e., filling penetrant and plasticization, gas hydrostatic pressure effect, and creation of free volumes and holes. © 1998 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 36: 3049-3056, 1998
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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