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  • 1
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract In order to describe the impact of corrosion of medical implants on the trace element balance of man samples of blood, serum and of a variety of tissues and organs were analysed for their trace element composition using instrumental neutron activation techniques. By the analysis of blood and serum the trace element status after long-term implantation as well as its dependence on time after implantation was investigated. Using autopsy samples of human organs such as heart, spleen, liver, of aorta and of lymphatic tissue from the lower pelvis transport and storage of the corrosion products was studided. These investigations were supplemented by a comprehensive study of “normal” human blood, serum, tissues and organs from patients without implants. The results demonstrate that there are high enrichments of corrosion products in several tissues and organs and that also blood and serum reveal the presence of the metal implants in the trace element levels, increasing shortly after implantation and pertaining during the entire implantation time. Thus the corrosion of metallic implants is a process not only affecting tissues from the vicinity of the implants but also influencing the trace element balance of the entire organism.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 103 (1984), S. 85-95 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Für 18 Elemente wurde die Spurenelementzusammensetzung menschlicher Gewebe (Gelenkkapsel des Hüftgelenks und Fascia lata) mit Hilfe instrumenteller Neutronenaktivierungsanalyse vor and nach Anwendung von Totalendoprothesen des Hüftgelenks aus Kobalt-Chrom-Legierungen untersucht. Die Gewebe aus der Umgebung der Implantate zeigten extreme Belastungen mit Korrosionsprodukten der Metalle (Co, Cr, Ni) sowie mit Zr, Hf und Ba aus den Knochenzementen. Die Gewebe aus größer Entfernung zum Implantat zeigten niedrigere, jedoch noch signifikante Belastung. Sogar nich in den Implantat-Materialen enthaltene essentielle Spurunelemente ware in ihrer Häufigkeit nach Implantation verändert. Um die korrosive Auflösung der Liegerungsbestandteile in biologischen Medien zu untersuchen, wurde die Passierung von Co-Cr-Legierungen mit Hilfe der Trace-Technik untersucht. Dabei wurde Ringer-Lösung als einfaches Modell für die Körperflüssigkeiten gewählt. Der Passivierungsprozeß dauerte mehr als 2 Monat und war von einer selektiven Auflösung der Legierungsbestandtiele in der Reihenfolge Ni 〉 Co ∼ Fe 〉 Mo 〉 Cr begleitet. Ein Vergleich der Gewebeanalysen mit den Korrosionsexperimente zeigte, daß die Verteilung der Korrosionsprozeß, als auch durch die biochemischen Eigenschaften der Legierungsbestandteile bestimmt werden.
    Notes: Summary Using instrumental neutron activation analysis, the concentrations of 18 elements were studied in human articular capsule and fascia lata before and after application of total endoprostheses of the hip joint made of cobalt-chromium alloys. Tissues from the vicinity of the implant showed extreme burdening by corrosion products (Co, Cr, Ni), as well as by Zr, Hf, and Ba from the bone cements. Tissues more distant from the implants exhibited lower, but still significant burdening. Moreover, some essential trace elements not contained in the implant materials were changed in the tissues after implantation. In order to clarify the dissolution of alloy constituents in biological media, the passivation of cobalt-chromium alloy was investigated by tracer techniques using Ringer's solution as a simple model of the body fluids. The passivation process lasted for more than 1 month and was accompanied by a selective dissolution of the alloys constituents in the order Ni 〉 Co ≈ Fe 〉 Mo 〉 Cr. A comparison of the tissue analyses with the corrosion experiments demonstrates that the distribution patterns of the corrosion products in the tissues are influenced by both the corrosion process and the biochemical properties of the corrosion products.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 100 (1982), S. 243-247 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Drei Fälle von Hämangiomen der Skelettmuskulatur werden beschrieben. Die Pathologie, Symptomatik, Diagnostik und Therapie werden besprochen. Wenn sich eine Schwellung in der Muskulatur zeigt, sollte differentialdiagnostisch an ein Angiom gedacht werden. Die operative Ausräumung und — bei inkompletter Exzision oder Rezidivierung —Radiotherapie sind die Methoden der Wahl.
    Notes: Summary Three cases of intramuscular haemangioma are described and their pathology, symptoms, diagnosis and therapy are discussed. If a swelling occurs in the muscular system an angioma should be thought of. Removal by operation and radiotherapy of the tumour is the usual therapy.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 107 (1988), S. 288-292 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 28 patients with surgically proved loosening of hip-joint endoprostheses and 42 patients without loosening between 2 and 12 years after implantation and without clinical or radiological signs of loosening we performed clinical evaluation, and radiographs, a three-phase bone scan, and a 111indium-labeled leukocyte scan (ILLS). The sensitivity of radiographs in the group with loosening of hip-joint endoprostheses in the femoral as well as in the acetabular component was only about 50%, while the specificity was almost 100%. With a combination of radiographs and ILLS we reached a sensitivity in the acetabular component of 100% and in the femoral component of 88%, but specificities of only 57% in the acetabular component and 40% in the femoral component were found. We found that the ILLS is a very helpful method of examination to detect loosening of hip-joint arthroplasties in doubtful cases.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 290 (1978), S. 109-110 
    ISSN: 1618-2650
    Keywords: Best. von Metallen in Biolog. Material ; Aktivierungsanalyse, Neutronen ; Spuren, Gewebe nach Osteotomie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 3 (1981), S. 110-117 
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The corrosion behaviour of orthopaedic metal implants was studied in an animal experiment in which 30 rabbits had stainless steel plates implanted after a varization osteotomy of the tibiae of their hind legs for one year. ESCA was used for the investigation of the surfaces of the inplants. The removed plates were covered by an easily destroyable 3-5 nm thick oxidic layer which contained Cr(III), Fe(II), Fe(III), Mo(VI) and Mo(IV), but no Ni. This passive layer (and possibly also the nearest metal layer below it) is strongly enriched in Cr. Additionally, corrosion experiments with radioactivated implants in Ringer's solution demonstrated that the passivation of the stainless steel is accompanied by marked selective solution of the steel constituents. The observed solubilities (Co 〉 Ni 〉 Fe 〉 Mo 〉 Cr) are inversely correlated with the abundance of the respective element in the passive layer. The trace element composition of the tissues was measured by instrumental neutron activation analysis. It turned out that the actual burdening of the tissues surrounding the implants by corrosion products is exhibited by strong enrichments of the elements Cr, Fe, Co, Ni and Mo relative to their normal concentrations. While Cr, Co, Ni and Mo are abundant in fairly constant ratios in the contact tissues, the excess of Fe is influenced by biological regulation mechanisms. The extent to which the distribution patterns of steel-specific elements in animal (and human) tissues can be explained by the dissolution of the steel during the passivation process is discussed.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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