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  • 1
    ISSN: 1432-1440
    Keywords: Tobacco-specific nitrosamines ; Toxicokinetics ; Genotoxicity ; Systemic effects ; Primary cells ; Detection of DNA damage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An ex vivo model to detect nonspecific DNA damage in different rat tissues has been developed and employed to study systemic properties of tobacco-specific N-nitrosamines. One hour after treatment of rats with the carcinogens, primary, intact cells were isolated from various organs. Viability of the cells was monitored by trypan blue exclusion. Genotoxicity was determined by alkaline elution, in situ nick translation or microgel electrophoresis. We found that oral application of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces genotoxic effects in the liver (3.125–50 mg/kg), whereas N-nitrosonornicotine (NNN) is only moderately active (50–100 mg/kg). Furthermore, oral administration of NNK, NNN, and of N-nitrosodimethylamine (NDMA), induces DNA damage in the nasal cavity. In peripheral blood lymphocytes genotoxicity of NDMA (〈 2 mg/kg), but not of NNK (50 mg/kg), was observed. NDMA and NNK are just as genotoxic in the liver when administered by inhalation as orally (effective doses: 0.1–1 and 50 mg/kg, respectively). For human cancer, these results indicate that in addition to the susceptibilities in local organs (oral cavity after snuff dipping and lung after tobacco smoke inhalation), these nitrosamines also pose a risk systemically for more remote organs.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Organometallic Chemistry 468 (1994), S. 63-68 
    ISSN: 0022-328X
    Keywords: Alkyne ; Allyl ; Silyl ; Triflate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0027-5107
    Keywords: 2,4-Dimethoxyaniline ; Bladder carcinogens ; o-Anisidine ; p-Cresidine
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract From the R./V. “Meteor” and the Pakistan F./V. “Machhera” sediments from the Indian-Pakistan continental margin have been investigated in order to delineate the facies distribution of the recent deposits. One of several objectives of this study was to find out how far the suspended material of the Indus River is being transported into the Arabian Sea. A close genetic relationship was recognised between the oceanographic conditions of the water masses (chemistry and currents) and the characteristics of the sediments. The activity of the monsoons is reflected by the rhythmic lamination of the sediments of the upper continental slope. The suspended matter from the Indus River can be traced far into the Arabian Sea. The clay minerals show the following tendency from litoral to abyssal regions and from the top of the cores downward: detrital clay minerals (chlorite, muscovite, illite) — degraded clay minerals (montmorillonite, mixed-layer minerals) — “re-formational” minerals (illite). The biostratigraphic investigation of the sediments combined with several C14-dates results in sedimentation rates from 〉 50 cm/1000 years at the upper continental slope decreasing to about 1 cm/1000 years in the open ocean. The faunal composition proves the existence of a climatic optimum during part of the Holocene. The geochemical investigation of the recent pore fluids demonstrates that their composition very soon assumes the characteristics of fossil interstitial waters (cf. V.Marchig, in this vol.). p The results will be published in “Meteor”-Forschungsergebnisse, Reihe C.
    Abstract: Résumé La tâche à remplir consista à saisir les conditions de sédimentation au fond de la mer dans la zone bordière du talus continental indo-pakistanais en se servant des échantillons de sédimentation recueillis par le navire d'exploration «Meteor» et par le cutter de pêche et de recherche scientifique pakistanais «Machhera» et, entre autres, à tenter de déterminer oú les masses de boue de l'Indus se retrouvent sur le fond de la Mer d'Oman. Il fut possible de reconnaître des relations étroites existant entre les conditions océanographiques (chimisme et courants) et la formation des sédiments. Des sédiments rubanés à stratification fine sur le talus continental supérieur reflètent les effets d'alternance des moussons. Il est possible de suivre les sédiments de l'Indus jusqu'à une grande distance dans les profondeurs de l'océan. Avec l'éloignement da la côte et, dans les carottes, avec l'augmentation de la profondeur de prélèvement les minéraux argileux montrent la tendance suivante: «matériel détritique» (chlorite, muscovite, illite) — «matériel de décomposition chimique» (montmorillonite, minéraux de couches mixtes) — «matériel de recombinaison minéralogique» (illite). L'étude biostratigraphique combinée aux résultats de quelques déterminations radiométriques au14C donne, entre autres, des taux de sédimentation jusqu'à 〉 50 cm/1.000 ans au talus continental supérieur — taux qui vont décroissant jusqu'à environ 1 cm/1.000 ans en plein océan. La composition faunique prouve l'existence d'une phase climatique optimum à l'Holocène. L'analyse géochimique des eaux interstitielles récentes montre que cellesci peuvent atteindre, dans uns délai assez bref, la composition des eaux fossiles. (V.Marchig, en ce tome). La publication des résultats est prévue dans les «Meteor» Forschungsergebnisse, Ser. C.
    Notes: Zusammenfassung Mit Sedimentmaterial, das von dem Forschungsschiff „Meteor“ und dem pakistanischen Fischereiforschungskutter „Machhera“ gesammelt wurde, sollten die Ablagerungsbedingungen auf dem Meeresboden des indisch-pakistanischen Kontinentalrandes erfaßt und unter anderem festzustellen versucht werden, wo die Schlammassen des Indus auf dem Meeresboden des Arabischen Meeres wiederzufinden sind (Abb. 1). Enge Beziehungen zwischen den ozeanographischen Verhältnissen im Wasserraum (Chemismus und Strömungen) und der Ausbildung der Sedimente konnten erkannt werden. Rhythmisch gebänderte Sedimente auf dem oberen Kontinentalabhang spiegeln die weitreichenden Auswirkungen des Monsunwechsels wider. Indusmaterial ist bis weit in die Tiefsee zu verfolgen. Die Tonmineralien zeigen von der Küste zur Tiefsee und auch mit zunehmender Teufe in den Sedimentkernen die Tendenz: „Detritus“ (Chlorit, Muskovit, Illit) — „Zersatz“ (Montmorrillonit, mixed layer-Minerale) — „Rückbildung“ (Illit). Die liostratigraphische Bearbeitung, kombiniert mit den Ergebnissen einiger C14-Datierungen ergibt u. a. Sedimentationsraten bis zu 〉 50 cm/1000 Jahre am oberen Kontinentalabhang abnehmend auf ca. 1 cm/1000 Jahre im offenen Ozean. Die Faunenzusammensetzung erweist das Vorhandensein eines holozänen Klimaoptimums. Die geochemische Untersuchung der jungen Forenwässer zeigt, daß diese sehr schnell die Zusammensetzung fossiler Formationswässer erreichen können (siehe V.Marchig, i. d. Bd.).
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1335
    Keywords: Agaricus bisporus ; Histidine artefacts ; Genotoxic effects ; Salmonella typhimurium ; Primary rat hepatocytes ; DNA amplification ; Short-term in vivo tests ; micronuclei ; DNA single-strand breaks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A. bisporus has been reported to be carcinogenic to mice [Toth et al. (1986) Cancer Res 38:177–180] and mutagenic inSalmonella typhimurium [Sterner et al. (1982) Mutat Res 101:269–281]. The effects of different heat treatments on the mutagenicity of raw, cooked (boiled) and friedA. bisporus extracts in theS. typhimurium test is reported. The spectrum of potential mutagenic activity ofA. bisporus extracts was tested in vitro in Syrian hamster embryo cells for selective DNA amplification and in primary rat hepatocytes for DNA singlestrand breaks. DNA single-strand breaks were also determined in liver cells of rats and micronuclei were measured in bone marrow cells of mice in vivo following oral application ofA. bisporus extracts. It was shown that the complexA. bisporus extracts per se are not detectably mutagenic inS. typhimurium and that the previously observed increase in number of colonies per plate is probably due to a histidine artefact. No indication of genotoxicity was seen in the two in vitro assays with primary mammalian cells with two different end points. No evidence of in vivo genotoxic effects was observed in the rat liver cells. Finally,A. bisporus was not genotoxic in the micronucleus assay of mouse bone marrow cells in contrast to its previously reported carcinogenicity in mice.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Wood science and technology 13 (1979), S. 315-316 
    ISSN: 1432-5225
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Wood science and technology 18 (1984), S. 1-17 
    ISSN: 1432-5225
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Summary The reasons for changes in wood quality and utilization are related to the trends toward harvesting smaller, younger and lower-quality timber, wider use of formerly waste wood, unconventional uses of wood, and improved forest management and new wood manufacturing techniques. 1. An unequal distribution of timber along with increasing costs of forest ownership and management is forcing short-rotation forestry, which results in small-sized timber, low-quality wood, and a high proportion of juvenile wood and knots. This is true for almost all forest regions although it has been most evident in tropical plantations. The economic pressures for short-rotation ages will become increasingly great, especially in those areas where a timber imbalance in age class distribution occurs. 2. Especially in the Tropics, many forestry organizations are planting exotic species on a massive scale and are producing a large volume of “different” wood. The trend toward using exotics is very strong. The trees attain a merchantable size at young ages, with thinning being standard; this produces a large proportion of juvenile wood. Such wood is not desirable for some products, based on current quality criteria, and may be distinctly different from the wood that the same species produces in its indigenous environment. Huge amounts of it are now becoming available, requiring a reassessment of both manufacturing techniques and product type and quality. 3. Better utilization in forest harvesting operations results in the use of mill residues of bark and sawdust and forest residues of bark, limbs, leaves, stumps and roots that formerly were considered to be waste. There is also greater utilization of previously unwanted species, including some which were once considered to be of limited value and often were destroyed during regeneration programs. Of great importance are the technological developments that are enabling a greater utilization of the grossly differing woods found growing together in tropical forests, rather than using only a few species and destroying the rest. 4. Wood quality is very responsive to both silvicultural and genetic manipulation. The improvements possible in wood will partially offset some quality declines caused by young wood and lower quality trees. The quickest and easiest method of changing wood quality is to control age of harvest. 5. New industries are developing which use wood as a source of energy and organic chemicals. In some areas, wood for energy is primarily obtained from large forests being planted solely for energy needs and is secondarily obtained as a salvage product from the forest. From 20 to 50% of the wood harvested in the world is for firewood, which often results in a marked reduction of the quality of the wood used for industrial purposes. Currently some research is focused to grow trees which will yield improved energy and chemicals. 6. New manufacturing techniques, such as oriented strand-board and the endgluing of short, clear wood segments from low-quality logs, are enabling the production of high-quality products from low-quality timber. These manufacturing techniques result in products that differ markedly from those previously available but they are stable and of excellent quality. However, a strong sales program will be needed to assure acceptance of the different products.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 43 (1973), S. 319-322 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The effects of competition on the growth of families of loblolly pine (Pinus taeda, L.) seedlings were investigated. The experimental design made it possible to evaluate the effects of crowding on growth and to determine the types and magnitudes of intergenotypic interactions among pairs of families. The results showed that intergenotypic interactions were both highly variable and pronounced in their effect on early growth. Evidence was also found for precompetition cooperating interactions occurring among seedlings surrounded by neighbors of the same family.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 32 (1993), S. 131-138 
    ISSN: 1436-6215
    Keywords: Pestizide ; Kombinationswirkungen ; Mutagenität ; Genotoxicity ; quercetin ; herbicides ; atrazine ; cyanazine ; combination effects ; SCE test ; HPRT test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary The plant flavonol quercetin and the triazine herbicides atrazine, cyanazine, and gesamprim were examined individually and in combination for the induction of genotoxic effects. The sister chromatid exchange (SCE) assay and the gene mutation assay for 6-thioguanine resistance (HPRT) were carried out with Chinese hamster ovary (CHO) cells. Whereas no evidence of an increased SCE rate was found, the test substances caused a slightly increased mutation rate in the HPRT assay after metabolic activation with a subcellular liver enzyme preparation. Combination studies with two or three of the test substances did not result in higher mutation rates than those observed for the individual compounds tested singly.
    Notes: Zusammenfassung Das in Plfanzen vorkommende Flavonol Quercetin und die zu den Triazinen gehörenden Herbizide Atrazin, Cyanazin und Gesamprim® wurden einzeln und in Kombination miteinander auf genotoxische Wirkungen untersucht. Es wurden die Induktion von Schwesterchromatidaustauschen (SCE-Test) und von Mutationen zur 6-Thioguaninresistenz (HPRT-Test) an Ovarzellen des Chinesischen Hamsters (CHO-Zellen) bestimmt. Während sich in SCE-Test keine Hinweise auf genotoxische Wirkungen ergaben, verursachten die Prüfsubstanzen im HPRT-Test nach metabolischer Aktivierung durch zugesetzte subzelluläre Enzympräparate der Rattenleber (S9-Mix) leicht erhöhte Mutationsraten. Die Kombinationen von zwei oder drei Prüfsubstanzen verursachten keine deutliche Zunahme der genotoxischen Wirkung.
    Type of Medium: Electronic Resource
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